SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PGR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 ARG A 624
ALA A 549
ASP A 622
GLY A 617
 PGR  A 805 (-4.2A)
None
PGR  A 805 (-3.4A)
PGR  A 805 ( 4.9A)
 1.15A 1e7cA-1yiqA:
2.2		 1e7cA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 5 HIS A 661
GLU A 694
ALA A 700
SER A 699
 None
None
None
PGR  A1777 (-3.3A)
 1.31A 1errA-2xe4A:
undetectable
1errB-2xe4A:
undetectable		 1errA-2xe4A:
16.23
1errB-2xe4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 548
VAL A 615
LEU A 446
MET A 449
PHE A 385
 None
None
None
None
PGR  A 803 ( 4.3A)
 1.43A 1mx1E-1yiqA:
undetectable		 1mx1E-1yiqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 617
GLY A 548
GLY A 611
GLN A 557
ASP A 622
 PGR  A 805 ( 4.9A)
None
None
None
PGR  A 805 (-3.4A)
 0.80A 1wg8B-1yiqA:
undetectable		 1wg8B-1yiqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3eo7 PUTATIVE
NITROREDUCTASE
(Trichormus
variabilis) 		4 / 5 ILE A 379
LEU A 440
ALA A 499
GLU A 498
 None
None
PGR  A 716 ( 4.9A)
None
 1.14A 1xvaA-3eo7A:
undetectable
1xvaB-3eo7A:
undetectable		 1xvaA-3eo7A:
21.40
1xvaB-3eo7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 631
PHE A 634
TYR A 665
ARG A 624
 None
HEM  A 901 ( 4.7A)
PGR  A 804 (-4.5A)
PGR  A 805 (-4.2A)
 1.09A 2i30A-1yiqA:
2.2		 2i30A-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3eo7 PUTATIVE
NITROREDUCTASE
(Trichormus
variabilis) 		4 / 6 GLY A 482
PHE A 483
LYS A  17
THR A  16
 None
None
PGR  A 716 ( 4.7A)
None
 1.34A 2m2oB-3eo7A:
undetectable		 2m2oB-3eo7A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 LYS A 668
ASP A 672
ARG A 624
TYR A 665
 PGR  A 804 (-2.9A)
None
PGR  A 805 (-4.2A)
PGR  A 804 (-4.5A)
 1.39A 2x8oA-1yiqA:
0.0		 2x8oA-1yiqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 4 ARG A 664
GLY A 696
GLU A 179
SER A 710
 PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
PGR  A1777 ( 3.5A)
 1.27A 2xctS-2xe4A:
2.5
2xctU-2xe4A:
undetectable		 2xctS-2xe4A:
22.58
2xctU-2xe4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 667
HIS A 631
PHE A 634
ARG A 624
 None
None
HEM  A 901 ( 4.7A)
PGR  A 805 (-4.2A)
 0.93A 3b9lA-1yiqA:
2.1		 3b9lA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 8 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.13A 3jq7B-2xe4A:
4.0		 3jq7B-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.16A 3jqaA-2xe4A:
2.8		 3jqaA-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.15A 3jqaB-2xe4A:
2.7		 3jqaB-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.15A 3jqaC-2xe4A:
4.2		 3jqaC-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.17A 3jqaD-2xe4A:
2.7		 3jqaD-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 11 ALA A 556
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.26A 3uudA-2xe4A:
undetectable		 3uudA-2xe4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 5 HIS A 312
TYR A 413
GLY A 309
SER A 311
 PGR  A1744 (-3.8A)
PGR  A1757 (-4.8A)
PGR  A1744 (-3.5A)
PGR  A1744 ( 2.6A)
 1.20A 4fu8A-2xe4A:
undetectable		 4fu8A-2xe4A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 4 ILE A 509
SER A 508
ASP A 516
ASP A 482
 PGR  A1765 (-4.1A)
PGR  A1765 ( 2.5A)
GOL  A1734 (-3.5A)
None
 0.91A 4krhB-2xe4A:
undetectable		 4krhB-2xe4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 12 LEU A 598
THR A 724
ALA A 715
ILE A 712
ILE A  79
 PGR  A1742 (-4.0A)
None
None
None
None
 1.04A 4o2bB-2xe4A:
2.5		 4o2bB-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 THR A 545
GLY A 617
ILE A 612
SER A 607
LEU A 552
 None
PGR  A 805 ( 4.9A)
None
None
PGR  A 805 (-4.6A)
 1.27A 4pooA-1yiqA:
undetectable		 4pooA-1yiqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 12 LEU A 688
LEU A 598
THR A 724
ALA A 715
ILE A  79
 None
PGR  A1742 (-4.0A)
None
None
None
 1.14A 4x1kD-2xe4A:
undetectable		 4x1kD-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 11 LEU A 688
LEU A 598
THR A 724
ALA A 715
ILE A  79
 None
PGR  A1742 (-4.0A)
None
None
None
 1.15A 4x20D-2xe4A:
undetectable		 4x20D-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 5 ARG A 664
GLY A 696
GLU A 179
SER A 710
 PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
PGR  A1777 ( 3.5A)
 1.25A 4z3oA-2xe4A:
1.8
4z3oB-2xe4A:
3.8		 4z3oA-2xe4A:
23.21
4z3oB-2xe4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 7 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.88A 5btaA-2xe4A:
undetectable
5btaC-2xe4A:
undetectable
5btaD-2xe4A:
3.0		 5btaA-2xe4A:
20.42
5btaC-2xe4A:
20.42
5btaD-2xe4A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.91A 5btaA-2xe4A:
undetectable
5btaB-2xe4A:
2.2
5btaC-2xe4A:
undetectable		 5btaA-2xe4A:
20.42
5btaB-2xe4A:
16.17
5btaC-2xe4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.85A 5btcA-2xe4A:
undetectable
5btcC-2xe4A:
undetectable
5btcD-2xe4A:
2.0		 5btcA-2xe4A:
20.42
5btcC-2xe4A:
20.42
5btcD-2xe4A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.87A 5btcA-2xe4A:
undetectable
5btcB-2xe4A:
1.9
5btcC-2xe4A:
undetectable		 5btcA-2xe4A:
20.42
5btcB-2xe4A:
16.17
5btcC-2xe4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 7 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.91A 5btfA-2xe4A:
undetectable
5btfB-2xe4A:
2.9
5btfC-2xe4A:
undetectable		 5btfA-2xe4A:
20.42
5btfB-2xe4A:
16.17
5btfC-2xe4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 7 SER A 710
ARG A 664
GLY A 696
GLU A 179
 PGR  A1777 ( 3.5A)
PO4  A1791 (-4.6A)
None
PGR  A1748 ( 4.5A)
 0.92A 5btfA-2xe4A:
undetectable
5btfC-2xe4A:
undetectable
5btfD-2xe4A:
3.4		 5btfA-2xe4A:
20.42
5btfC-2xe4A:
20.42
5btfD-2xe4A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 SER A 476
ASP A 552
ARG A 527
GLY A 529
 PGR  A1749 (-2.9A)
None
PGR  A1747 (-4.0A)
None
 0.92A 5cdqA-2xe4A:
undetectable
5cdqC-2xe4A:
undetectable
5cdqD-2xe4A:
2.2		 5cdqA-2xe4A:
22.03
5cdqC-2xe4A:
22.03
5cdqD-2xe4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 ALA A 524
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.33A 5dx3A-2xe4A:
undetectable		 5dx3A-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 ALA A 671
GLU A  68
LEU A 689
ARG A 678
GLY A 600
 None
None
None
None
PGR  A1742 (-3.5A)
 1.33A 5dx3A-2xe4A:
undetectable		 5dx3A-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 ALA A 524
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.29A 5dxbA-2xe4A:
undetectable		 5dxbA-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 ALA A 671
GLU A  68
LEU A 689
ARG A 678
GLY A 600
 None
None
None
None
PGR  A1742 (-3.5A)
 1.35A 5dxbA-2xe4A:
undetectable		 5dxbA-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 11 ALA A 524
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.24A 5dxgB-2xe4A:
undetectable		 5dxgB-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 12 MET A 503
ALA A 524
LEU A 493
MET A 492
GLY A 575
 PGR  A1764 ( 3.5A)
None
None
None
PGR  A1742 (-4.2A)
 0.88A 5gtrA-2xe4A:
undetectable		 5gtrA-2xe4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 12 LEU A 598
THR A 724
ALA A 715
ILE A 712
ILE A  79
 PGR  A1742 (-4.0A)
None
None
None
None
 1.03A 5mioB-2xe4A:
2.5		 5mioB-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 9 ALA A 524
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.24A 5wgqA-2xe4A:
undetectable		 5wgqA-2xe4A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		3 / 3 LEU A 342
VAL A 384
ASP A 379
 GOL  A1733 (-4.6A)
CL  A1798 ( 3.9A)
PGR  A1760 ( 4.3A)
 0.64A 5x23A-2xe4A:
undetectable		 5x23A-2xe4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 12 LEU A 598
THR A 724
ALA A 715
ILE A 712
ILE A  79
 PGR  A1742 (-4.0A)
None
None
None
None
 1.01A 5xiwD-2xe4A:
2.6		 5xiwD-2xe4A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		4 / 6 GLN A 713
VAL A 596
MET A 503
PRO A 513
 PGR  A1742 ( 3.2A)
None
PGR  A1764 ( 3.5A)
None
 1.21A 6brdB-2xe4A:
undetectable		 6brdB-2xe4A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 11 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.49A 6mb5A-2xe4A:
undetectable		 6mb5A-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.44A 6mb7A-2xe4A:
0.0		 6mb7A-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.47A 6mb9A-2xe4A:
undetectable		 6mb9A-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.46A 6mb9B-2xe4A:
undetectable		 6mb9B-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 2xe4 OLIGOPEPTIDASE B
(Leishmania
major) 		5 / 10 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.47A 6mb9C-2xe4A:
undetectable		 6mb9C-2xe4A:
7.74