SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PGH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VH3_A_DAHA2_1 (RANASMURFIN)	3ypi	TRIOSEPHOSPHATE ISOMERASE (Saccharomyces cerevisiae)	5 / 9	ALA A 169 ALA A 176 PHE A 229 SER A 211 ALA A 212	None None None PGH A 249 (-3.7A) None	1.49A	2vh3A-3ypiA: undetectable	2vh3A-3ypiA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	1gvf	TAGATOSE-BISPHOSPHAT E ALDOLASE AGAY (Escherichia coli)	5 / 11	ALA A 175 ALA A 173 GLY A 209 HIS A 208 GLY A 139	None None PGH A 287 ( 3.1A) ZN A 288 ( 3.1A) None	1.13A	2x1lC-1gvfA: undetectable	2x1lC-1gvfA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V1N_A_BEZA288_0 (2-HYDROXY-6-OXO-6-PH ENYLHEXA-2,4-DIENOAT E HYDROLASE)	1gvf	TAGATOSE-BISPHOSPHAT E ALDOLASE AGAY (Escherichia coli)	5 / 8	GLY A 139 GLY A 209 ILE A 189 LEU A 207 VAL A 213	None PGH A 287 ( 3.1A) None None None	1.35A	3v1nA-1gvfA: undetectable	3v1nA-1gvfA: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_A_Y00A406_0 (BETA-1 ADRENERGIC RECEPTOR)	1gvf	TAGATOSE-BISPHOSPHAT E ALDOLASE AGAY (Escherichia coli)	5 / 12	THR A 50 ASP A 82 SER A 106 VAL A 231 ASN A 230	None PGH A 287 (-2.6A) None PGH A 287 (-3.9A) PGH A 287 (-4.3A)	1.39A	6h7lA-1gvfA: undetectable	6h7lA-1gvfA: 16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_B_Y00B405_0 (BETA-1 ADRENERGIC RECEPTOR)	1gvf	TAGATOSE-BISPHOSPHAT E ALDOLASE AGAY (Escherichia coli)	5 / 12	THR A 50 ASP A 82 SER A 106 VAL A 231 ASN A 230	None PGH A 287 (-2.6A) None PGH A 287 (-3.9A) PGH A 287 (-4.3A)	1.39A	6h7lB-1gvfA: undetectable	6h7lB-1gvfA: 16.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2VH3_A_DAHA2_1","RANASMURFIN","3ypi","TRIOSEPHOSPHATE ISOMERASE","Saccharomyces cerevisiae",5,"ALA A 169;ALA A 176;PHE A 229;SER A 211;ALA A 212","None;None;None;PGH A 249 (-3.7A);None","1.49A","2vh3A-3ypiA:undetectable",null],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","1gvf","TAGATOSE-BISPHOSPHATE ALDOLASE AGAY","Escherichia coli",5,"ALA A 175;ALA A 173;GLY A 209;HIS A 208;GLY A 139","None;None;PGH A 287 ( 3.1A); ZN A 288 ( 3.1A);None","1.13A","2x1lC-1gvfA:undetectable","2vh3A-3ypiA:19.35"],["3V1N_A_BEZA288_0","2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE","1gvf","TAGATOSE-BISPHOSPHATE ALDOLASE AGAY","Escherichia coli",5,"GLY A 139;GLY A 209;ILE A 189;LEU A 207;VAL A 213","None;PGH A 287 ( 3.1A);None;None;None","1.35A","3v1nA-1gvfA:undetectable","2x1lC-1gvfA:21.41"],["6H7L_A_Y00A406_0","BETA-1 ADRENERGIC RECEPTOR","1gvf","TAGATOSE-BISPHOSPHATE ALDOLASE AGAY","Escherichia coli",5,"THR A  50;ASP A  82;SER A 106;VAL A 231;ASN A 230","None;PGH A 287 (-2.6A);None;PGH A 287 (-3.9A);PGH A 287 (-4.3A)","1.39A","6h7lA-1gvfA:undetectable","3v1nA-1gvfA:22.70"],["6H7L_B_Y00B405_0","BETA-1 ADRENERGIC RECEPTOR","1gvf","TAGATOSE-BISPHOSPHATE ALDOLASE AGAY","Escherichia coli",5,"THR A  50;ASP A  82;SER A 106;VAL A 231;ASN A 230","None;PGH A 287 (-2.6A);None;PGH A 287 (-3.9A);PGH A 287 (-4.3A)","1.39A","6h7lB-1gvfA:undetectable","6h7lA-1gvfA:16.60"]]