SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PGE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 8 GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.69A 1ax9A-4be9A:
43.6		 1ax9A-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.09A 1axwA-6aujA:
35.7		 1axwA-6aujA:
64.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.70A 1axwA-6aujA:
35.7		 1axwA-6aujA:
64.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		5 / 12 LEU E 114
ALA E 158
GLY E 162
TYR E 180
PHE E  41
 None
None
None
PGE  E 402 (-4.8A)
None
 1.38A 1brpA-6bm7E:
undetectable		 1brpA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.42A 1bx4A-2qcvA:
30.2		 1bx4A-2qcvA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.85A 1c6yB-6c2hA:
undetectable		 1c6yB-6c2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 8 ASP A  60
TRP A 144
ARG A 173
THR A 141
 PGE  A 304 (-2.8A)
None
None
None
 1.46A 1ceaA-5lk4A:
undetectable
1ceaB-5lk4A:
undetectable		 1ceaA-5lk4A:
20.37
1ceaB-5lk4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.90A 1dx6A-3fnbA:
14.6		 1dx6A-3fnbA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.31A 1dx6A-4be9A:
42.2		 1dx6A-4be9A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
TRP A 147
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
PGE  A 303 ( 4.6A)
 0.76A 1dx6A-4q3kA:
18.4		 1dx6A-4q3kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3qbm TETR TRANSCRIPTIONAL
REGULATOR
(Chloroflexus
aurantiacus) 		4 / 5 PHE A  19
TYR A  24
LEU A 119
VAL A  12
 None
None
PGE  A 210 ( 4.9A)
None
 1.42A 1dz6A-3qbmA:
undetectable		 1dz6A-3qbmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.69A 1eizA-3lvvA:
undetectable		 1eizA-3lvvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.75A 1ej0A-3lvvA:
undetectable		 1ej0A-3lvvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		4 / 8 PHE A 101
CYH A  51
VAL A  47
GLY A 133
 None
None
None
PGE  A 900 ( 4.3A)
 0.90A 1ekjE-3we9A:
undetectable
1ekjF-3we9A:
undetectable		 1ekjE-3we9A:
23.00
1ekjF-3we9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Parabacteroides
distasonis) 		4 / 6 CYH A  35
ASP A  91
VAL A  95
HIS A  53
 None
CA  A 391 ( 2.9A)
None
PGE  A 403 (-4.4A)
 1.43A 1ekjG-3mdoA:
undetectable
1ekjH-3mdoA:
undetectable		 1ekjG-3mdoA:
20.56
1ekjH-3mdoA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 6 LEU A 102
GLU A 180
THR A 143
ALA A 146
 PGE  A 302 ( 3.7A)
1GP  A 301 (-2.1A)
None
None
 1.27A 1etb2-4jejA:
undetectable		 1etb2-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 139
GLY A 143
LEU A  98
GLY A 136
MET A  96
 None
None
PGE  A 302 ( 3.6A)
None
PGE  A 302 ( 3.3A)
 1.21A 1fduC-4mm1A:
undetectable		 1fduC-4mm1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 10 MET A 283
GLN A 226
VAL A 249
ILE A 265
GLY A 199
 None
PGE  A 402 (-3.5A)
None
None
PGE  A 402 ( 3.9A)
 1.49A 1fohA-5i77A:
undetectable		 1fohA-5i77A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 4 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.24A 1gmkA-3rbyA:
undetectable
1gmkB-3rbyA:
undetectable		 1gmkA-3rbyA:
6.17
1gmkB-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 4 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.29A 1gmkC-3rbyA:
undetectable
1gmkD-3rbyA:
undetectable		 1gmkC-3rbyA:
6.17
1gmkD-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		3 / 3 TRP A  46
VAL A   7
TRP A  21
 PGE  A 701 (-3.6A)
None
PGE  A 701 ( 4.6A)
 1.48A 1gmkC-2ofkA:
undetectable
1gmkD-2ofkA:
undetectable		 1gmkC-2ofkA:
9.21
1gmkD-2ofkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4j6o METALLOPHOSPHOESTERA
SE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 334
LEU A 171
VAL A 313
PHE A 330
 None
None
PGE  A 502 (-4.2A)
None
 1.00A 1gsfC-4j6oA:
undetectable		 1gsfC-4j6oA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		4 / 8 PHE A 182
LEU A 236
VAL A 108
PHE A 314
 None
None
PGE  A 402 ( 4.1A)
None
 1.02A 1gsfC-4pf6A:
undetectable		 1gsfC-4pf6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 7 GLY A 253
ASP A 468
SER A 223
ALA A 466
 None
None
None
PGE  A1554 ( 4.6A)
 0.93A 1gxsA-4be9A:
8.3
1gxsB-4be9A:
0.7		 1gxsA-4be9A:
18.94
1gxsB-4be9A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
CYH A  52
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.51A 1h4oB-4k1fA:
17.5		 1h4oB-4k1fA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
CYH A  52
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.51A 1h4oG-4k1fA:
17.3		 1h4oG-4k1fA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN
(Yersinia
pestis) 		4 / 6 PHE A 187
LYS A 215
LYS A 214
ALA A 213
 None
None
PGE  A 407 (-2.7A)
None
 1.24A 1hk2A-5eqvA:
undetectable		 1hk2A-5eqvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3r7t ADENYLOSUCCINATE
SYNTHETASE
(Campylobacter
jejuni) 		4 / 6 PRO A 362
ASP A 278
ASP A 282
TYR A 364
 None
None
PGE  A 422 ( 4.9A)
None
 1.47A 1hpkA-3r7tA:
undetectable		 1hpkA-3r7tA:
11.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 GLU A  66
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.84A 1hvyA-6aujA:
33.5		 1hvyA-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 GLU A  66
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.86A 1hvyA-6aujA:
33.5		 1hvyA-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 GLU A  66
ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.81A 1hvyC-6aujA:
33.7		 1hvyC-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 GLU A  66
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.88A 1hvyD-6aujA:
33.5		 1hvyD-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 GLU A  66
ILE A  87
TRP A  88
LEU A 151
PHE A 184
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
PGE  A 301 (-3.7A)
 0.73A 1hvyD-6aujA:
33.5		 1hvyD-6aujA:
51.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkB-3ij3A:
0.2		 1hwkB-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkA-3ij3A:
undetectable		 1hwkA-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkD-3ij3A:
0.7		 1hwkD-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.49A 1hwkC-3ij3A:
0.5		 1hwkC-3ij3A:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		7 / 9 GLU A  66
ILE A  87
TRP A  88
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.76A 1i00A-6aujA:
33.4		 1i00A-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 9 ASP A 177
LEU A 180
GLY A 181
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 ( 4.9A)
None
 0.90A 1i00B-6aujA:
33.8		 1i00B-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 9 ILE A  87
ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.47A 1i00B-6aujA:
33.8		 1i00B-6aujA:
51.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 PRO A 153
LEU A 158
THR A 148
ARG A 221
 None
None
PGE  A 306 (-4.7A)
PO4  A 302 (-3.1A)
 1.07A 1i2wA-5lk4A:
undetectable		 1i2wA-5lk4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 LEU A 599
ASN A 476
GLN A 609
THR A 481
 PGE  A 905 (-4.7A)
PGE  A 905 (-4.3A)
None
PGE  A 906 (-4.4A)
 1.02A 1ig3A-5bwdA:
undetectable
1ig3B-5bwdA:
undetectable		 1ig3A-5bwdA:
14.22
1ig3B-5bwdA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ASP A 238
ARG A 270
GLY A  86
GLY A 201
 PGE  A 503 (-3.7A)
PGE  A 503 (-3.1A)
None
None
 0.76A 1jr1B-4ogzA:
5.8		 1jr1B-4ogzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		4 / 6 ARG A 206
GLY A 199
ASP A 267
TYR A 240
 PGE  A 401 (-3.2A)
PGE  A 401 (-3.1A)
PGE  A 401 ( 4.4A)
None
 1.31A 1kf6M-4kryA:
undetectable
1kf6N-4kryA:
undetectable		 1kf6M-4kryA:
19.42
1kf6N-4kryA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA
(Escherichia
coli;
Salmonella
enterica) 		4 / 7 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
None
None
PGE  A 502 (-4.4A)
 1.18A 1kglA-4exkA:
undetectable		 1kglA-4exkA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 11 ASN A  72
LEU A  26
HIS A  19
GLY A  90
PHE A 315
 None
None
PGE  A 402 (-3.9A)
None
PGE  A 402 (-4.0A)
 1.42A 1l5rA-6b8sA:
undetectable		 1l5rA-6b8sA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 1liiA-2qcvA:
27.7		 1liiA-2qcvA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.44A 1likA-2qcvA:
31.6		 1likA-2qcvA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
TYR A 144
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.42A 1maaC-4be9A:
40.4		 1maaC-4be9A:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		4 / 8 GLY A 165
TYR A 301
SER A 233
HIS A 377
 PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.93A 1maaD-3fnbA:
13.9		 1maaD-3fnbA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 8 GLY A 134
GLU A 219
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
 0.39A 1maaD-4be9A:
37.0		 1maaD-4be9A:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3roh LEUCOTOXIN LUKEV
(Staphylococcus
aureus) 		4 / 5 TYR A 269
GLU A 281
PHE A 273
TYR A  96
 None
None
None
PGE  A 312 (-4.2A)
 1.02A 1mclA-3rohA:
1.8
1mclB-3rohA:
2.1
1mclP-3rohA:
undetectable		 1mclA-3rohA:
20.48
1mclB-3rohA:
20.48
1mclP-3rohA:
0.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.08A 1mj2B-6c2hA:
undetectable		 1mj2B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.06A 1mj2D-6c2hA:
undetectable		 1mj2D-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.04A 1mjoB-6c2hA:
undetectable		 1mjoB-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.02A 1mjoA-6c2hA:
undetectable		 1mjoA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.07A 1mjoD-6c2hA:
undetectable		 1mjoD-6c2hA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.7A)
None
 0.51A 1mx1D-4be9A:
41.3		 1mx1D-4be9A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 133
GLY A 134
LEU A 138
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
None
None
None
 0.78A 1mx1F-4be9A:
40.8		 1mx1F-4be9A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 315
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.3A)
1PE  A1553 (-4.7A)
None
 0.67A 1mx1F-4be9A:
40.8		 1mx1F-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
CYH A  52
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.51A 1oc3A-4k1fA:
17.2		 1oc3A-4k1fA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.91A 1ohrA-6c2hA:
undetectable		 1ohrA-6c2hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.92A 1qtiA-3fnbA:
14.0		 1qtiA-3fnbA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.43A 1qtiA-4be9A:
43.6		 1qtiA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.81A 1qtiA-4be9A:
43.6		 1qtiA-4be9A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3wjs NADH OXIDASE
(Gluconobacter
oxydans) 		4 / 4 LEU A 205
ILE A 216
ARG A 220
TYR A 154
 None
None
PGE  A 401 (-3.7A)
None
 1.48A 1rk3A-3wjsA:
undetectable		 1rk3A-3wjsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 GLN A 157
TYR A 153
THR A 133
GLU A 132
TYR A  89
 PGE  A 404 (-2.9A)
None
PGE  A 404 ( 4.0A)
None
None
 1.39A 1rkwA-5m8bA:
undetectable		 1rkwA-5m8bA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 8 ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.42A 1rtsA-6aujA:
34.2		 1rtsA-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 8 ILE A  87
ASP A 177
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 (-3.7A)
None
 0.52A 1rtsA-6aujA:
34.2		 1rtsA-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 7 ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
None
 0.74A 1rtsB-6aujA:
34.0		 1rtsB-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.53A 1rtsB-6aujA:
34.0		 1rtsB-6aujA:
49.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 5 ILE A 214
ARG A 155
LEU A 138
PRO A 217
 PGE  A 412 (-4.6A)
None
None
None
 1.46A 1s8fA-5nfqA:
2.9
1s8fB-5nfqA:
2.8		 1s8fA-5nfqA:
undetectable
1s8fB-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 177
GLY A 174
SER A 259
GLU A 185
PRO A 333
 None
None
PGE  A 417 (-2.8A)
None
None
 0.95A 1sg9B-3wjpA:
undetectable		 1sg9B-3wjpA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 ALA A  95
ASP A 175
VAL A 173
ILE A 109
 None
PGE  A 402 (-3.0A)
None
None
 0.81A 1t7iB-4nn3A:
undetectable		 1t7iB-4nn3A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 ALA A  95
ASP A 175
VAL A 173
ILE A 109
 None
PGE  A 402 (-3.0A)
None
None
 0.79A 1t7jB-4nn3A:
undetectable		 1t7jB-4nn3A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		4 / 7 ASN A 173
HIS A 175
ILE A 135
TRP A   6
 None
ZN  A 201 (-3.1A)
None
PGE  A 701 (-3.4A)
 1.48A 1tdnA-2ofkA:
undetectable		 1tdnA-2ofkA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
LEU A 151
GLY A 181
 None
None
PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
 0.94A 1tlsA-6aujA:
35.5		 1tlsA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
LEU A 151
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.64A 1tlsA-6aujA:
35.5		 1tlsA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 0.88A 1tlsA-6aujA:
35.5		 1tlsA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.11A 1tlsB-6aujA:
35.8		 1tlsB-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 0.88A 1tlsB-6aujA:
35.8		 1tlsB-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.22A 1tsnA-6aujA:
35.6		 1tsnA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
LEU A 151
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.69A 1tsnA-6aujA:
35.6		 1tsnA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 0.90A 1tsnA-6aujA:
35.6		 1tsnA-6aujA:
65.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4dtg HUMANIZED
RECOMBINANT FAB
FRAGMENT, FAB 2021,
OF A MURINE
ANTIBODY, HEAVY
CHAIN
TISSUE FACTOR
PATHWAY INHIBITOR
(Homo
sapiens) 		4 / 6 GLU K  11
SER H  54
TYR H  59
TYR H  57
 PGE  H 304 ( 3.5A)
None
None
None
 1.21A 1tufA-4dtgK:
undetectable
1tufB-4dtgK:
undetectable		 1tufA-4dtgK:
9.76
1tufB-4dtgK:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 10 LEU A  16
ILE A  71
THR A  65
LYS A  68
THR A  88
 None
None
None
None
PGE  A1107 ( 4.9A)
 1.48A 1tw4B-2yn1A:
undetectable		 1tw4B-2yn1A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		4 / 6 LEU A 143
PHE A 140
ALA A 141
LEU A 119
 EDO  A 505 ( 4.6A)
None
PGE  A 504 (-3.6A)
None
 0.81A 1ukbA-4pv4A:
undetectable		 1ukbA-4pv4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.86A 1w6rA-3fnbA:
14.4		 1w6rA-3fnbA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.35A 1w6rA-4be9A:
42.2		 1w6rA-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.86A 1w6rA-4be9A:
42.2		 1w6rA-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 11 GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.36A 1w76A-4be9A:
43.7		 1w76A-4be9A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 10 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.92A 1w76B-3fnbA:
13.8		 1w76B-3fnbA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 10 GLY A 133
GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.33A 1w76B-4be9A:
43.7		 1w76B-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.04A 1w76B-4be9A:
43.7		 1w76B-4be9A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3kkd TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 THR A 200
LEU A 199
ILE A 203
VAL A 138
LEU A 231
 PGE  A 238 ( 4.5A)
None
PGE  A 238 ( 4.6A)
None
None
 1.32A 1wsvA-3kkdA:
undetectable		 1wsvA-3kkdA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3kkd TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 THR A 200
LEU A 199
ILE A 203
VAL A 138
LEU A 231
 PGE  A 238 ( 4.5A)
None
PGE  A 238 ( 4.6A)
None
None
 1.33A 1wsvB-3kkdA:
undetectable		 1wsvB-3kkdA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 MET A 294
VAL A 318
LEU A 314
PHE A 281
 FMN  A 400 (-4.6A)
None
None
PGE  A 404 (-4.5A)
 1.14A 1x8vA-4uwmA:
undetectable		 1x8vA-4uwmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5di0 NATTERIN-LIKE
PROTEIN
(Danio
rerio) 		5 / 12 GLY A 130
GLY A  15
GLY A  14
PHE A  18
SER A 132
 PEG  A 406 (-3.5A)
PGE  A 413 ( 4.9A)
None
PEG  A 406 (-4.9A)
PGE  A 413 (-3.5A)
 1.11A 1xdsA-5di0A:
undetectable		 1xdsA-5di0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5di0 NATTERIN-LIKE
PROTEIN
(Danio
rerio) 		5 / 12 GLY A 130
GLY A  15
GLY A  14
PHE A  18
SER A 132
 PEG  A 406 (-3.5A)
PGE  A 413 ( 4.9A)
None
PEG  A 406 (-4.9A)
PGE  A 413 (-3.5A)
 1.09A 1xdsB-5di0A:
undetectable		 1xdsB-5di0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 5 ALA A 471
TYR A 470
ALA A 485
GLN A 505
 PGE  A 906 ( 4.8A)
None
None
None
 0.98A 1xl6A-5bwdA:
2.4
1xl6B-5bwdA:
undetectable		 1xl6A-5bwdA:
17.35
1xl6B-5bwdA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wmd ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 TYR A  54
MET A  25
LEU A  49
THR A  88
GLN A 167
 None
None
PGE  A 402 ( 4.8A)
None
None
 1.47A 1xomB-4wmdA:
undetectable		 1xomB-4wmdA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.03A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 311
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.00A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.01A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 1.02A 1ya4B-4jejA:
undetectable		 1ya4B-4jejA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]
(Onchocerca
volvulus) 		5 / 12 GLY A  90
GLY A  93
VAL A  14
LEU A  42
LEU A 147
 PGE  A 206 ( 3.2A)
None
None
PGE  A 206 (-3.6A)
None
 0.95A 1ya4C-5in2A:
undetectable		 1ya4C-5in2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 0.96A 1ya4C-4jejA:
undetectable		 1ya4C-4jejA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 5 ALA A 176
PHE A 211
ASN A 185
ILE A 186
 None
None
PGE  A 301 ( 4.9A)
None
 0.92A 1yc2D-6aujA:
undetectable		 1yc2D-6aujA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 5 CYH A 202
PRO A 221
THR A 371
THR A 317
 None
PGE  A 390 ( 4.6A)
None
None
 1.17A 1ymxB-3r9pA:
undetectable		 1ymxB-3r9pA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 11 LEU A  71
ILE A 195
PHE A 168
ASP A 166
GLY A 221
 PGE  A 422 (-3.7A)
None
PGE  A 422 (-3.9A)
None
None
 1.25A 1zz1A-4bofA:
undetectable		 1zz1A-4bofA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.14A 2a58A-3tb4A:
3.7
2a58B-3tb4A:
3.8		 2a58A-3tb4A:
21.30
2a58B-3tb4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.13A 2a58B-3tb4A:
3.8
2a58C-3tb4A:
3.1		 2a58B-3tb4A:
21.30
2a58C-3tb4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.13A 2a58D-3tb4A:
3.8
2a58E-3tb4A:
3.8		 2a58D-3tb4A:
21.30
2a58E-3tb4A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 9 GLY A 133
GLY A 134
SER A 220
ALA A 221
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-2.9A)
1PE  A1553 (-3.5A)
None
 0.87A 2aceA-4be9A:
42.4		 2aceA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 9 GLY A 134
GLY A 135
SER A 220
ALA A 221
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-3.5A)
None
None
 0.92A 2aceA-4be9A:
42.4		 2aceA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 7 GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.72A 2ackA-4be9A:
42.7		 2ackA-4be9A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 8 PHE A  83
LEU A 308
ILE A 307
HIS A 306
 None
None
None
PGE  A   3 ( 4.6A)
 0.90A 2azxA-3iibA:
undetectable		 2azxA-3iibA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 552
ASP A 594
CYH A 609
 None
None
PGE  A1785 ( 4.2A)
 1.09A 2br4E-4a2lA:
undetectable		 2br4E-4a2lA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wmd ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 SER A 147
TYR A 164
HIS A 175
HIS A 166
 PGE  A 402 ( 3.9A)
None
None
PGE  A 402 (-4.6A)
 1.31A 2bteA-4wmdA:
undetectable		 2bteA-4wmdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wmd ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 SER A 147
TYR A 164
HIS A 175
HIS A 166
 PGE  A 402 ( 3.9A)
None
None
PGE  A 402 (-4.6A)
 1.32A 2bteD-4wmdA:
undetectable		 2bteD-4wmdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ALA A 101
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.41A 2c49A-2qcvA:
32.5		 2c49A-2qcvA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 11 THR A3760
GLN A3992
ALA A3991
ALA A3970
ALA A3968
 None
PGE  A4204 (-4.6A)
PGE  A4204 (-3.2A)
None
None
 1.15A 2f16H-5ii5A:
undetectable
2f16I-5ii5A:
undetectable		 2f16H-5ii5A:
20.28
2f16I-5ii5A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 11 THR A3760
GLN A3992
ALA A3991
ALA A3970
ALA A3968
 None
PGE  A4204 (-4.6A)
PGE  A4204 (-3.2A)
None
None
 1.13A 2f16V-5ii5A:
undetectable
2f16W-5ii5A:
undetectable		 2f16V-5ii5A:
20.28
2f16W-5ii5A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 7 ARG A 157
ASN A 256
ASP A 254
GLY A 160
 None
PGE  A 406 ( 4.6A)
None
None
 1.05A 2f6dA-2r09A:
undetectable		 2f6dA-2r09A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		4 / 7 ALA A  88
ASP A  89
GLY A  82
ILE A  81
 None
PEG  A 402 (-3.8A)
PGE  A 413 (-3.4A)
None
 0.92A 2fxdB-5nfqA:
undetectable		 2fxdB-5nfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 LEU A 227
ALA A 218
THR A 241
VAL A 248
ARG A 352
 None
None
None
PGE  A1403 ( 4.1A)
PO4  A1404 (-2.9A)
 1.12A 2g78A-1ozhA:
undetectable		 2g78A-1ozhA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		3 / 3 ASN A 281
TYR A  94
SER A 221
 ACT  A 323 (-3.8A)
PGE  A 321 (-3.8A)
None
 0.91A 2gvcB-3o66A:
undetectable		 2gvcB-3o66A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		3 / 3 ASN A 281
TYR A  94
SER A 221
 ACT  A 323 (-3.8A)
PGE  A 321 (-3.8A)
None
 0.93A 2gvcE-3o66A:
undetectable		 2gvcE-3o66A:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 8 GLY A 134
GLY A 135
ALA A 221
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-3.5A)
None
None
 1.02A 2ha4A-4be9A:
40.3		 2ha4A-4be9A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 7 GLY A 134
GLY A 135
ALA A 221
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-3.5A)
None
 0.25A 2ha4B-4be9A:
41.5		 2ha4B-4be9A:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLU A 165
ASN A 182
LEU A 198
LEU A 290
TYR A 202
 PGE  A 503 (-3.8A)
None
None
None
None
 1.48A 2ha6A-5tu0A:
undetectable		 2ha6A-5tu0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLU A 165
ASN A 182
LEU A 198
LEU A 290
TYR A 202
 PGE  A 503 (-3.8A)
None
None
None
None
 1.47A 2ha6B-5tu0A:
undetectable		 2ha6B-5tu0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 7 LEU A  79
LEU A  76
SER A  38
TYR A 112
 PGE  A 278 (-4.5A)
None
None
PGE  A 278 ( 4.3A)
 1.23A 2hc4A-3p77A:
undetectable		 2hc4A-3p77A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 THR A 634
ALA A 151
TYR A 269
PHE A 318
 None
PGE  A 777 ( 3.7A)
None
None
 1.12A 2hzqA-2f3oA:
undetectable		 2hzqA-2f3oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5xd0 GLUCANASE
(Paenibacillus
sp.
X4) 		4 / 5 ASP A 158
LEU A 205
GLY A 206
ARG A 219
 None
None
None
PGE  A 501 ( 4.9A)
 0.91A 2j2pA-5xd0A:
undetectable
2j2pB-5xd0A:
undetectable		 2j2pA-5xd0A:
21.87
2j2pB-5xd0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5xd0 GLUCANASE
(Paenibacillus
sp.
X4) 		4 / 4 ASP A 158
LEU A 205
GLY A 206
ARG A 219
 None
None
None
PGE  A 501 ( 4.9A)
 0.96A 2j2pD-5xd0A:
undetectable
2j2pE-5xd0A:
undetectable		 2j2pD-5xd0A:
21.87
2j2pE-5xd0A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.24A 2kceA-6aujA:
35.6		 2kceA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ASP A 177
GLY A 181
TYR A 217
 None
PGE  A 301 (-4.1A)
None
PGE  A 301 ( 4.0A)
None
 0.80A 2kceA-6aujA:
35.6		 2kceA-6aujA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.69A 2kceB-6aujA:
35.9		 2kceB-6aujA:
65.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 LEU A 120
LEU A 132
MET A   1
GLU A   2
 PGE  A 301 ( 4.8A)
PGE  A 301 ( 4.7A)
PGE  A 301 (-4.9A)
None
 1.26A 2kuhA-4rhoA:
undetectable		 2kuhA-4rhoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA
(Nakamurella
multipartita) 		5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
 PGE  A 203 ( 4.8A)
None
None
None
None
 0.94A 2nxeB-4hbzA:
2.8		 2nxeB-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 7 GLY A  71
THR A  14
MET A  66
SER A  11
 None
PGE  A 502 ( 4.3A)
None
None
 1.13A 2o5yH-3c8fA:
undetectable
2o5yL-3c8fA:
undetectable		 2o5yH-3c8fA:
20.22
2o5yL-3c8fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 6 THR A 395
ASP A 335
ASN A 408
ASP A 409
 None
None
None
PGE  A 908 ( 4.8A)
 1.23A 2okcA-5bwdA:
undetectable		 2okcA-5bwdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 5 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.12A 2p2fA-4uozA:
undetectable		 2p2fA-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.14A 2p2fB-4uozA:
3.7		 2p2fB-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.47A 2pkkA-2qcvA:
31.7		 2pkkA-2qcvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 498
GLY A 503
ALA A 222
GLY A 559
ASP A 501
 None
PGE  A1684 ( 3.9A)
PGE  A1684 ( 4.5A)
None
None
 0.96A 2pkkA-3zukA:
undetectable		 2pkkA-3zukA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.46A 2pkmA-2qcvA:
31.6		 2pkmA-2qcvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 LEU A 100
ILE A  13
SER A 104
VAL A 145
VAL A 229
 PGE  A 302 (-3.7A)
None
None
PGE  A 302 ( 4.7A)
1GP  A 301 (-4.1A)
 1.08A 2po7A-4jejA:
3.0		 2po7A-4jejA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 271
ASP A 270
GLU A 334
 None
PGE  A 509 ( 4.9A)
None
 0.70A 2qeuA-4mrqA:
undetectable		 2qeuA-4mrqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 271
ASP A 270
GLU A 334
 None
PGE  A 509 ( 4.9A)
None
 0.71A 2qeuC-4mrqA:
undetectable		 2qeuC-4mrqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		4 / 6 GLY A 163
GLY A 196
GLN A 304
PHE A 205
 None
None
None
PGE  A 404 ( 4.5A)
 1.02A 2qx6A-3fnbA:
2.3
2qx6B-3fnbA:
3.0		 2qx6A-3fnbA:
19.36
2qx6B-3fnbA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.54A 2tsrA-6aujA:
34.3		 2tsrA-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 10 GLU A  66
ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.61A 2tsrC-6aujA:
33.9		 2tsrC-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 9 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.56A 2tsrD-6aujA:
33.9		 2tsrD-6aujA:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
VAL A  51
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.49A 2v32C-4k1fA:
22.6
2v32D-4k1fA:
22.6		 2v32C-4k1fA:
30.64
2v32D-4k1fA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
VAL A  51
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.48A 2v41C-4k1fA:
22.6
2v41D-4k1fA:
22.7		 2v41C-4k1fA:
30.64
2v41D-4k1fA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
VAL A  51
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.54A 2v41C-4k1fA:
22.7
2v41D-4k1fA:
22.7		 2v41C-4k1fA:
30.64
2v41D-4k1fA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4k1f TRYPAREDOXIN
PEROXIDASE
(Leishmania
major) 		4 / 8 PRO A  45
THR A  49
VAL A  51
ARG A 128
 None
PGE  A 201 ( 4.1A)
None
None
 0.55A 2v41G-4k1fA:
22.4
2v41H-4k1fA:
22.4		 2v41G-4k1fA:
30.64
2v41H-4k1fA:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xwl EXOGLUCANASE S
(Clostridium
cellulovorans) 		4 / 7 PRO A  91
SER A  92
PRO A  85
GLY A  86
 None
None
None
PGE  A 707 ( 4.5A)
 0.83A 2y7kA-4xwlA:
undetectable		 2y7kA-4xwlA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
 None
None
None
None
PGE  A1403 ( 4.1A)
 1.01A 2ygoA-1ozhA:
undetectable		 2ygoA-1ozhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 ILE A 279
ILE A 281
ILE A 335
PHE A 212
VAL A 248
 None
None
None
None
PGE  A1403 ( 4.1A)
 1.01A 2ygqA-1ozhA:
0.0		 2ygqA-1ozhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA
(Nakamurella
multipartita) 		5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
 PGE  A 203 ( 4.8A)
None
None
None
None
 0.93A 2zbpA-4hbzA:
undetectable		 2zbpA-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.08A 2zj0B-4zjgA:
undetectable		 2zj0B-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 0.95A 2zj0C-4zjgA:
undetectable		 2zj0C-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3u34 GENERAL STRESS
PROTEIN
(Xanthomonas
citri) 		4 / 8 ALA A  91
TRP A 150
GLY A  90
ILE A  89
 PGE  A 183 (-4.3A)
None
None
None
 0.90A 2zm9A-3u34A:
undetectable		 2zm9A-3u34A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.90A 2zxwP-6c0tA:
1.7
2zxwW-6c0tA:
undetectable		 2zxwP-6c0tA:
undetectable
2zxwW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.94A 3ablP-6c0tA:
1.9
3ablW-6c0tA:
undetectable		 3ablP-6c0tA:
undetectable
3ablW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 319
SER A 256
HIS A  10
LEU A 285
TYR A  12
 PGE  A 404 (-4.6A)
PGE  A 404 ( 4.1A)
FMN  A 400 (-3.7A)
None
PGE  A 404 (-4.5A)
 1.46A 3adsA-4uwmA:
undetectable		 3adsA-4uwmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5gjn LYSINE/ORNITHINE
DECARBOXYLASE
(Selenomonas
ruminantium) 		5 / 12 ARG A 112
LEU A 214
ILE A  91
ALA A 197
ASP A 213
 PGE  A 406 (-3.9A)
None
None
None
PGE  A 406 (-3.8A)
 1.04A 3axtA-5gjnA:
2.1		 3axtA-5gjnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		3 / 3 HIS A 119
GLU A  24
HIS A 197
 PGE  A 301 (-3.3A)
None
None
 0.90A 3ba0A-4r9xA:
undetectable		 3ba0A-4r9xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 VAL B 525
VAL B 554
PHE B 583
ARG B 405
 PGE  B 604 ( 4.6A)
None
None
None
 1.35A 3bjwH-5jjdB:
undetectable		 3bjwH-5jjdB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		5 / 11 ALA A 101
LEU A 103
ARG A 100
ILE A  68
PRO A  65
 None
None
PGE  A 903 (-2.9A)
None
None
 1.00A 3bpxA-2ofkA:
undetectable
3bpxB-2ofkA:
undetectable		 3bpxA-2ofkA:
21.28
3bpxB-2ofkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.02A 3ce6B-4zjgA:
undetectable		 3ce6B-4zjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.02A 3ce6D-4zjgA:
undetectable		 3ce6D-4zjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA
(Nakamurella
multipartita) 		5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
 PGE  A 203 ( 4.8A)
None
None
None
None
 0.97A 3cjtG-4hbzA:
undetectable		 3cjtG-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 ASP A  17
ASP A 141
SER A 218
SER A 166
ALA A 156
 PGE  A 403 ( 2.9A)
TRS  A 402 (-3.0A)
None
None
None
 1.16A 3d91A-5m8bA:
undetectable		 3d91A-5m8bA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 LYS A 109
TYR A 220
ASP A 236
GLN A 239
 None
PGE  A 321 ( 3.4A)
None
None
 1.27A 3dh0A-3o66A:
undetectable		 3dh0A-3o66A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 12 GLY A 156
GLY A 129
VAL A 162
ALA A 152
LEU A 238
 PGE  A 900 ( 3.8A)
PGE  A 900 ( 3.8A)
None
None
None
 1.11A 3dh0B-3we9A:
undetectable		 3dh0B-3we9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 166
ASP A  59
ASP A 172
 PGE  A 698 (-4.3A)
None
None
 0.66A 3douA-3lvvA:
undetectable		 3douA-3lvvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.93A 3ekxA-6c2hA:
undetectable		 3ekxA-6c2hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4udj UHGB_MP
(uncultured
organism) 		5 / 12 TYR A 300
ASN A  28
PRO A  29
THR A 307
SER A  41
 None
None
PGE  A 608 (-3.8A)
None
K  A 606 (-2.6A)
 1.27A 3g4lA-4udjA:
undetectable		 3g4lA-4udjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wmd ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 TYR A  54
MET A  25
LEU A  49
THR A  88
GLN A 167
 None
None
PGE  A 402 ( 4.8A)
None
None
 1.50A 3g4lD-4wmdA:
undetectable		 3g4lD-4wmdA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3u1x PUTATIVE GLYCOSYL
HYDROLASE
(Parabacteroides
distasonis) 		4 / 7 VAL A 189
TYR A 121
TRP A 107
GLU A 138
 None
None
None
PGE  A 260 (-3.2A)
 1.28A 3hs4A-3u1xA:
undetectable		 3hs4A-3u1xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE
(Salmonella
enterica) 		3 / 3 GLU A 106
ASP A 114
ASP A  27
 None
PGE  A 904 (-4.0A)
None
 0.75A 3jb2A-2ofkA:
undetectable		 3jb2A-2ofkA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ILE A  87
TRP A  88
LEU A 151
 None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.62A 3k2hA-6aujA:
33.3		 3k2hA-6aujA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
ILE A  87
TRP A  88
LEU A 151
PHE A 184
 None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
PGE  A 301 (-3.7A)
 1.04A 3k2hA-6aujA:
33.3		 3k2hA-6aujA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ILE A  87
TRP A  88
LEU A 151
 None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.63A 3k2hB-6aujA:
33.9		 3k2hB-6aujA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
ILE A  87
TRP A  88
LEU A 151
PHE A 184
 None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
PGE  A 301 (-3.7A)
 1.05A 3k2hB-6aujA:
33.9		 3k2hB-6aujA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 332
LEU A 266
LEU A 349
SER A 345
ILE A 352
 None
PGE  A 509 (-4.9A)
None
None
None
 1.18A 3ko0M-4mrqA:
undetectable
3ko0N-4mrqA:
undetectable
3ko0O-4mrqA:
undetectable
3ko0P-4mrqA:
undetectable		 3ko0M-4mrqA:
12.13
3ko0N-4mrqA:
12.13
3ko0O-4mrqA:
12.13
3ko0P-4mrqA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1
(Burkholderia) 		5 / 9 THR G 176
ALA G 175
LEU G 173
ALA G 164
SER G 165
 None
None
PGE  G 304 (-4.8A)
None
None
 1.23A 3kp6B-5nm7G:
undetectable		 3kp6B-5nm7G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		5 / 12 ALA A 168
GLY A  94
GLY A  93
ASP A 267
ASP A 164
 SEB  A 165 ( 3.4A)
SEB  A 165 ( 3.5A)
SEB  A 165 ( 3.6A)
PGE  A 401 ( 4.4A)
SEB  A 165 ( 4.4A)
 1.10A 3m6vA-4kryA:
undetectable		 3m6vA-4kryA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		5 / 12 ALA A 168
GLY A  94
GLY A  93
ASP A 267
ASP A 164
 SEB  A 165 ( 3.4A)
SEB  A 165 ( 3.5A)
SEB  A 165 ( 3.6A)
PGE  A 401 ( 4.4A)
SEB  A 165 ( 4.4A)
 1.10A 3m6vB-4kryA:
undetectable		 3m6vB-4kryA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 11 THR A3760
GLN A3992
ALA A3991
ALA A3970
ALA A3968
 None
PGE  A4204 (-4.6A)
PGE  A4204 (-3.2A)
None
None
 1.17A 3mg0V-5ii5A:
undetectable
3mg0W-5ii5A:
undetectable		 3mg0V-5ii5A:
20.28
3mg0W-5ii5A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 0.98A 3n58C-4zjgA:
undetectable		 3n58C-4zjgA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 VAL A3863
LEU A3827
GLY A3854
ALA A3855
LEU A4028
 PGE  A4205 ( 4.7A)
None
None
None
None
 1.01A 3n8yB-5ii5A:
undetectable		 3n8yB-5ii5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5xd0 GLUCANASE
(Paenibacillus
sp.
X4) 		4 / 5 ARG A 219
ASP A 158
ASP A 195
ASP A 207
 PGE  A 501 ( 4.9A)
None
None
None
 1.33A 3naiA-5xd0A:
1.5		 3naiA-5xd0A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 9 LEU A  93
PHE A  63
THR A 134
LEU A 173
GLY A  91
 None
PGE  A 301 (-4.3A)
None
None
None
 1.23A 3nxuB-4r9xA:
undetectable		 3nxuB-4r9xA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3k7c PUTATIVE NTF2-LIKE
TRANSPEPTIDASE
(Campylobacter
jejuni) 		4 / 7 ALA A  81
VAL A  85
VAL A  99
LEU A 101
 None
PGE  A 117 (-4.6A)
PGE  A 117 (-4.6A)
None
 0.74A 3o14A-3k7cA:
undetectable		 3o14A-3k7cA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1z1s HYPOTHETICAL PROTEIN
PA3332
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 112
PHE A  26
ASP A 117
SER A 103
SER A  10
 None
None
PGE  A 301 (-3.1A)
PGE  A 301 ( 3.9A)
None
 1.28A 3o1xA-1z1sA:
undetectable		 3o1xA-1z1sA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3t9y ACETYLTRANSFERASE,
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A  61
ILE A  54
ASP A 101
LEU A  98
TYR A  94
 None
None
PGE  A 205 (-4.7A)
None
None
 1.05A 3o7wA-3t9yA:
undetectable		 3o7wA-3t9yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA
(Nakamurella
multipartita) 		5 / 12 ALA A 138
GLY A 145
GLY A 143
LEU A 148
VAL A 129
 None
None
None
PGE  A 203 ( 4.8A)
None
 1.03A 3o7wA-4hbzA:
undetectable		 3o7wA-4hbzA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 7 GLY A 134
GLY A 135
SER A 220
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.7A)
None
 0.52A 3o9mA-4be9A:
42.6		 3o9mA-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		4 / 7 GLY A  93
GLY A  94
LEU A 221
HIS A 292
 SEB  A 165 ( 3.6A)
SEB  A 165 ( 3.5A)
PGE  A 401 (-4.1A)
SEB  A 165 ( 4.1A)
 0.48A 3o9mA-4kryA:
2.9		 3o9mA-4kryA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 6 GLY A 134
GLY A 135
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
 0.47A 3o9mB-4be9A:
42.6		 3o9mB-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		4 / 6 GLY A  93
GLY A  94
LEU A 221
HIS A 292
 SEB  A 165 ( 3.6A)
SEB  A 165 ( 3.5A)
PGE  A 401 (-4.1A)
SEB  A 165 ( 4.1A)
 0.49A 3o9mB-4kryA:
4.4		 3o9mB-4kryA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3u1x PUTATIVE GLYCOSYL
HYDROLASE
(Parabacteroides
distasonis) 		4 / 8 ASP A 143
GLN A 114
PRO A 148
GLN A 162
 None
None
None
PGE  A 260 (-4.2A)
 1.10A 3oyaA-3u1xA:
undetectable		 3oyaA-3u1xA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P73_A_ACTA276_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 5 ARG A  82
THR A 139
ARG A 142
TRP A 143
 ACT  A 274 (-2.9A)
ACT  A 274 (-3.2A)
ACT  A 275 ( 3.8A)
PGE  A 278 ( 4.6A)
 0.40A 3p73A-3p77A:
37.1		 3p73A-3p77A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 SER A  74
TYR A  94
THR A  97
ASN A 138
TYR A 244
 None
PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 (-3.8A)
 0.31A 3ppoA-3o66A:
36.5		 3ppoA-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 TYR A  94
THR A  97
ASN A 138
TYR A 220
TYR A 244
 PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 ( 3.4A)
PGE  A 321 (-3.8A)
 0.72A 3ppoA-3o66A:
36.5		 3ppoA-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 SER A  74
TYR A  94
THR A  97
ASN A 138
TYR A 244
 None
PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 (-3.8A)
 0.27A 3ppoB-3o66A:
36.7		 3ppoB-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 TYR A  94
THR A  97
ASN A 138
TYR A 220
TYR A 244
 PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 ( 3.4A)
PGE  A 321 (-3.8A)
 0.67A 3ppoB-3o66A:
36.7		 3ppoB-3o66A:
57.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN
(Cupriavidus
pinatubonensis) 		4 / 6 THR A 188
LEU A 187
GLU A  36
ASP A 184
 PGE  A 344 ( 4.9A)
None
None
PGE  A 344 ( 3.9A)
 1.04A 3ps9A-3iuzA:
undetectable		 3ps9A-3iuzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1z1s HYPOTHETICAL PROTEIN
PA3332
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 112
PHE A  26
ASP A 117
SER A 103
SER A  10
 None
None
PGE  A 301 (-3.1A)
PGE  A 301 ( 3.9A)
None
 1.29A 3qgzA-1z1sA:
undetectable		 3qgzA-1z1sA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		4 / 8 ARG A  43
ALA A  36
LEU A  28
ASP A  30
 None
PGE  A1200 ( 4.0A)
PGE  A1200 (-4.9A)
PGE  A1200 (-3.6A)
 0.94A 3qj7A-2wawA:
undetectable
3qj7D-2wawA:
undetectable		 3qj7A-2wawA:
21.64
3qj7D-2wawA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 VAL A  90
PHE A  99
LEU A 140
ILE A 143
 None
PGE  A 402 ( 4.5A)
None
None
 0.85A 3rfmA-4p56A:
undetectable		 3rfmA-4p56A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		3 / 3 PHE A 238
GLN A 348
PHE A 205
 PGE  A 404 (-4.7A)
None
PGE  A 404 ( 4.5A)
 0.81A 3rv5A-3fnbA:
undetectable		 3rv5A-3fnbA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I
(Cytophaga
hutchinsonii) 		4 / 4 LYS A 218
PHE A 219
PHE A  83
VAL A 118
 None
PGE  A 438 (-4.2A)
None
None
 1.18A 3rv5A-3h9mA:
0.0
3rv5B-3h9mA:
0.0		 3rv5A-3h9mA:
13.03
3rv5B-3h9mA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 VAL A   6
PHE A  94
PHE A  95
VAL A 118
 None
None
PGE  A 302 (-3.7A)
None
 1.35A 3rv5C-4mm1A:
undetectable
3rv5D-4mm1A:
undetectable		 3rv5C-4mm1A:
19.40
3rv5D-4mm1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
(Bdellovibrio
bacteriovorus) 		5 / 11 ARG A 246
LEU A 115
THR A 161
ASN A 253
GLY A 158
 PGE  A 505 (-3.2A)
None
None
TAU  A 501 (-3.1A)
TAU  A 501 ( 4.3A)
 1.12A 3sfuC-3v39A:
undetectable		 3sfuC-3v39A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5xd0 GLUCANASE
(Paenibacillus
sp.
X4) 		5 / 8 ASN A 132
ASP A 158
SER A  94
ASP A 195
GLU A 285
 None
None
PGE  A 501 ( 4.9A)
None
PGE  A 501 ( 4.4A)
 1.36A 3sg9B-5xd0A:
undetectable		 3sg9B-5xd0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		4 / 4 GLY A 234
GLY A 236
THR A 256
LEU A 345
 PGE  A 404 ( 4.5A)
None
None
None
 0.88A 3si7C-3fnbA:
undetectable
3si7D-3fnbA:
undetectable		 3si7C-3fnbA:
23.08
3si7D-3fnbA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		4 / 7 ILE A  75
PHE A  40
LYS A  63
GLY A  64
 None
None
None
PGE  A 302 ( 4.0A)
 1.13A 3sj0X-3g5jA:
undetectable		 3sj0X-3g5jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 5 LEU A 198
GLY A 199
PHE A 272
PHE A 293
 None
PGE  A 390 ( 4.4A)
None
None
 1.10A 3smtA-3r9pA:
undetectable		 3smtA-3r9pA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 5 LEU A 322
GLY A 319
PHE A 315
PHE A  84
 None
PGE  A 402 ( 4.2A)
PGE  A 402 (-4.0A)
None
 1.21A 3smtA-6b8sA:
undetectable		 3smtA-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLN A 195
GLY A 234
GLY A 165
PHE A 232
SER A 255
 None
PGE  A 404 ( 4.5A)
PGE  A 404 ( 4.1A)
None
None
 1.28A 3t7sA-3fnbA:
2.6		 3t7sA-3fnbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 163
ARG A 269
ASP A 267
PHE A 284
 SEB  A 165 ( 3.5A)
None
None
PGE  A 401 ( 4.4A)
None
 1.31A 3tkaA-4kryA:
3.0		 3tkaA-4kryA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.84A 3tkgC-6c2hA:
undetectable		 3tkgC-6c2hA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A 253
TRP A 239
TRP A 234
THR A 289
 None
None
PGE  A 503 (-3.8A)
None
 1.38A 3topA-5tu0A:
undetectable		 3topA-5tu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PRO A 288
ILE A 253
TRP A 239
TRP A 234
 None
None
None
PGE  A 503 (-3.8A)
 1.35A 3topB-5tu0A:
undetectable		 3topB-5tu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xwl EXOGLUCANASE S
(Clostridium
cellulovorans) 		4 / 5 ASN A 219
ALA A 220
PRO A 221
ALA A 225
 None
PGE  A 712 (-3.5A)
None
None
 1.28A 3twpD-4xwlA:
3.1		 3twpD-4xwlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5it6 GALECTIN-RELATED
PROTEIN
(Gallus
gallus) 		4 / 8 ARG A  62
GLY A  32
PHE A  31
SER A  34
 EDO  A 206 ( 3.6A)
PGE  A 205 ( 3.1A)
None
PGE  A 205 ( 3.5A)
 1.03A 3tzfB-5it6A:
undetectable		 3tzfB-5it6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		7 / 12 ASP A  22
GLY A  43
GLY A  44
SER A  45
ASN A  48
GLY A 269
ASP A 272
 None
None
None
PGE  A 332 ( 4.0A)
None
None
PGE  A 332 (-3.6A)
 0.55A 3uboA-2qcvA:
34.1		 3uboA-2qcvA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.40A 3uboB-2qcvA:
35.4		 3uboB-2qcvA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.81A 3uboB-2qcvA:
35.4		 3uboB-2qcvA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.40A 3uq6A-2qcvA:
32.4		 3uq6A-2qcvA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.38A 3uq6B-2qcvA:
31.4		 3uq6B-2qcvA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.45A 3vaqA-2qcvA:
32.2		 3vaqA-2qcvA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.45A 3vaqB-2qcvA:
31.4		 3vaqB-2qcvA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.40A 3vasA-2qcvA:
32.2		 3vasA-2qcvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.40A 3vasB-2qcvA:
22.8		 3vasB-2qcvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 SER A 240
ILE A 204
ILE A 236
LEU A 231
PHE A 256
 None
None
None
PGE  A1403 ( 4.2A)
PO4  A1404 (-4.7A)
 1.16A 3w67D-1ozhA:
undetectable		 3w67D-1ozhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 VAL A 278
SER A 240
ILE A 236
LEU A 231
PHE A 256
 None
None
None
PGE  A1403 ( 4.2A)
PO4  A1404 (-4.7A)
 1.26A 3w67D-1ozhA:
undetectable		 3w67D-1ozhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Listeria
monocytogenes) 		4 / 6 PRO A 293
GLY A 294
LEU A 181
GLU A 290
 None
PGE  A 381 (-4.8A)
PGE  A 381 ( 4.6A)
None
 0.97A 3zqtA-3ot5A:
0.9		 3zqtA-3ot5A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3wjs NADH OXIDASE
(Gluconobacter
oxydans) 		4 / 7 PRO A  12
ARG A 220
GLY A 168
VAL A  96
 None
PGE  A 401 (-3.7A)
None
None
 0.83A 4a3uB-3wjsA:
44.9		 4a3uB-3wjsA:
69.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4ubs PENTALENIC ACID
SYNTHASE
(Streptomyces
avermitilis) 		4 / 6 GLY A 242
ARG A 175
ILE A 240
LEU A 160
 HEM  A 501 (-3.6A)
PGE  A 506 (-4.0A)
DIF  A 502 (-3.3A)
None
 1.12A 4ac9C-4ubsA:
undetectable		 4ac9C-4ubsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 9 ILE A 109
GLY A 108
VAL A  10
THR A  37
GLY A 104
 None
PGE  A1200 ( 3.7A)
None
None
None
 1.40A 4acaB-2wawA:
undetectable
4acaC-2wawA:
undetectable		 4acaB-2wawA:
19.00
4acaC-2wawA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ubs PENTALENIC ACID
SYNTHASE
(Streptomyces
avermitilis) 		4 / 6 GLY A 242
ARG A 175
ILE A 240
LEU A 160
 HEM  A 501 (-3.6A)
PGE  A 506 (-4.0A)
DIF  A 502 (-3.3A)
None
 1.16A 4acaC-4ubsA:
undetectable		 4acaC-4ubsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 6 THR A  88
ILE A 241
THR A 102
PHE A  99
 None
None
None
PGE  A 402 ( 4.5A)
 0.89A 4acbC-4p56A:
undetectable		 4acbC-4p56A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1xqi NUCLEOSIDE
DIPHOSPHATE KINASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A 172
GLU A 183
ASP A 175
PRO A  64
 PGE  A 500 ( 3.7A)
PGE  A 500 (-3.7A)
PGE  A 500 (-2.9A)
PGE  A 500 (-4.4A)
 1.12A 4apjA-1xqiA:
undetectable
4apjP-1xqiA:
undetectable		 4apjA-1xqiA:
16.98
4apjP-1xqiA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 810
ARG A 807
ILE A 821
 None
PGE  A 906 (-3.1A)
None
 0.87A 4b7qA-4xkzA:
undetectable		 4b7qA-4xkzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 810
ARG A 807
ILE A 821
 None
PGE  A 906 (-3.1A)
None
 0.81A 4b7qC-4xkzA:
undetectable		 4b7qC-4xkzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.92A 4bupB-5brrE:
undetectable		 4bupB-5brrE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 8 ASN A 165
ASN A 114
THR A 115
TRP A 117
 None
PGE  A1508 (-4.0A)
None
None
 0.78A 4d1yA-4ci7A:
undetectable
4d1yB-4ci7A:
undetectable		 4d1yA-4ci7A:
17.83
4d1yB-4ci7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.46A 4dc3A-2qcvA:
30.7		 4dc3A-2qcvA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.46A 4dc3B-2qcvA:
32.3		 4dc3B-2qcvA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 6 THR A 248
TYR A 155
HIS A  11
TYR A 192
 PGE  A 373 (-3.3A)
PGE  A 373 ( 3.9A)
None
None
 1.44A 4df2A-3eqxA:
undetectable		 4df2A-3eqxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5eyg INOSITOL
MONOPHOSPHATASE
(Staphylococcus
aureus) 		4 / 6 THR A   5
HIS A  65
HIS A  83
TYR A 109
 PGE  A 306 ( 4.8A)
PGE  A 306 (-4.1A)
PGE  A 306 (-3.7A)
PGE  A 306 (-4.5A)
 1.38A 4df2A-5eygA:
undetectable		 4df2A-5eygA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 6 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 None
None
None
None
PGE  A 357 (-4.5A)
 1.23A 4dxuA-3fplA:
undetectable		 4dxuA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.33A 4e3aA-2qcvA:
35.7		 4e3aA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.87A 4e3aA-2qcvA:
35.7		 4e3aA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.46A 4e3aB-2qcvA:
35.3		 4e3aB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.86A 4e3aB-2qcvA:
35.3		 4e3aB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4xwl EXOGLUCANASE S
(Clostridium
cellulovorans) 		3 / 3 ARG A 305
TRP A 304
GLY A 295
 None
PGE  A 709 (-4.1A)
None
 1.04A 4e7cA-4xwlA:
undetectable		 4e7cA-4xwlA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ASP A 177
LEU A 180
GLY A 181
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 ( 4.9A)
None
 0.80A 4eb4A-6aujA:
33.1		 4eb4A-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 ILE A  87
ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.70A 4eb4A-6aujA:
33.1		 4eb4A-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.49A 4eb4B-6aujA:
33.1		 4eb4B-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ASP A 177
LEU A 180
GLY A 181
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 ( 4.9A)
None
 0.77A 4eb4B-6aujA:
33.1		 4eb4B-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ILE A  87
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.72A 4eb4B-6aujA:
33.1		 4eb4B-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 9 ILE A  87
ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.51A 4eb4C-6aujA:
33.8		 4eb4C-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 10 ASP A 177
LEU A 180
GLY A 181
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 ( 4.9A)
None
 0.85A 4eb4D-6aujA:
33.6		 4eb4D-6aujA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 10 ILE A  87
ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.55A 4eb4D-6aujA:
33.6		 4eb4D-6aujA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.90A 4ey6A-3fnbA:
14.8		 4ey6A-3fnbA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.25A 4ey6A-4be9A:
41.0		 4ey6A-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.94A 4ey6A-4be9A:
41.0		 4ey6A-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 3fnb ACYLAMINOACYL
PEPTIDASE SMU_737
(Streptococcus
mutans) 		5 / 12 GLY A 164
GLY A 165
TYR A 301
SER A 233
HIS A 377
 None
PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.88A 4ey6B-3fnbA:
14.3		 4ey6B-3fnbA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.28A 4ey6B-4be9A:
37.3		 4ey6B-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.91A 4ey6B-4be9A:
37.3		 4ey6B-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.13A 4feuF-5bwdA:
undetectable		 4feuF-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 7 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.11A 4fevD-5bwdA:
undetectable		 4fevD-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 7 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.11A 4fevF-5bwdA:
undetectable		 4fevF-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.10A 4fewD-5bwdA:
undetectable		 4fewD-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.11A 4fewF-5bwdA:
undetectable		 4fewF-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 7 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.13A 4fexB-5bwdA:
undetectable		 4fexB-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 12 GLY A  32
GLY A  33
MET A  55
ILE A   5
PHE A  63
 PGE  A 301 (-3.6A)
None
PGE  A 301 ( 4.4A)
None
PGE  A 301 (-4.3A)
 1.15A 4fglA-4r9xA:
undetectable
4fglB-4r9xA:
undetectable		 4fglA-4r9xA:
21.51
4fglB-4r9xA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 11 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.06A 4fogA-3g5jA:
undetectable		 4fogA-3g5jA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
ASP A 177
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.58A 4fogA-6aujA:
35.3		 4fogA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.13A 4fogA-6aujA:
35.3		 4fogA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
ILE A  87
TRP A  88
GLY A 181
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
 1.09A 4fogA-6aujA:
35.3		 4fogA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
ILE A  87
TRP A  88
LEU A 151
GLY A 181
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
PGE  A 301 ( 4.0A)
 0.76A 4fogA-6aujA:
35.3		 4fogA-6aujA:
61.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 11 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.09A 4fogC-3g5jA:
undetectable		 4fogC-3g5jA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		7 / 11 HIS A  59
SER A  62
ILE A  87
TRP A  88
TRP A  91
LEU A 151
GLY A 181
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
None
PGE  A 301 ( 4.0A)
 0.83A 4fogC-6aujA:
35.3		 4fogC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
ILE A  87
TRP A  91
GLY A 181
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.5A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
 1.19A 4fogC-6aujA:
35.3		 4fogC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
TRP A  91
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.5A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.30A 4fogC-6aujA:
35.3		 4fogC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 ILE A  87
TRP A  88
TRP A  91
LEU A 151
GLY A 181
 PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
None
PGE  A 301 ( 4.0A)
 0.94A 4fogD-6aujA:
35.5		 4fogD-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.96A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ASP A 177
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.61A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		7 / 12 HIS A  59
SER A  62
GLU A  66
ILE A  87
TRP A  88
TRP A  91
LEU A 151
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
None
 0.74A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.22A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
TRP A  91
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
PGE  A 301 (-3.7A)
 1.01A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  91
GLY A 181
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.5A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
 1.28A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
TRP A  91
ASP A 177
GLY A 181
 None
None
PGE  A 301 ( 4.5A)
None
PGE  A 301 ( 4.0A)
 0.95A 4foxA-6aujA:
35.5		 4foxA-6aujA:
61.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.09A 4foxB-3g5jA:
undetectable		 4foxB-3g5jA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ILE A  87
TRP A  88
LEU A 151
 None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.62A 4foxB-6aujA:
35.6		 4foxB-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.97A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
ASP A 177
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.65A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
GLU A  66
GLY A 181
TYR A 217
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.0A)
None
 0.86A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
GLU A  66
TRP A  88
TRP A  91
LEU A 151
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
None
 0.77A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
GLU A  66
TRP A  91
GLY A 181
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.5A)
PGE  A 301 ( 4.0A)
 0.98A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.31A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
TRP A  88
TRP A  91
PHE A 184
 None
None
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
PGE  A 301 (-3.7A)
 1.06A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
TRP A  91
ASP A 177
GLY A 181
 None
None
PGE  A 301 ( 4.5A)
None
PGE  A 301 ( 4.0A)
 0.99A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
TRP A  91
GLY A 181
PHE A 184
 None
None
PGE  A 301 ( 4.5A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
 1.41A 4foxC-6aujA:
35.2		 4foxC-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.94A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ASP A 177
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.60A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
GLU A  66
ILE A  87
TRP A  88
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
 0.46A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.25A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 1.02A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ILE A  87
TRP A  88
TRP A  91
 None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
 0.66A 4foxE-6aujA:
35.6		 4foxE-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 GLU A  66
ILE A  87
TRP A  88
TRP A  91
LEU A 151
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 ( 4.5A)
None
 0.76A 4foxF-6aujA:
35.4		 4foxF-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.35A 4foxF-6aujA:
35.4		 4foxF-6aujA:
61.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 102
ILE A 103
LEU A  82
ASP A  19
TYR A  26
 PGE  A 302 ( 3.9A)
None
None
None
None
 1.15A 4foxG-3g5jA:
undetectable		 4foxG-3g5jA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.88A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ASP A 177
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.62A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
GLU A  66
ILE A  87
TRP A  88
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
 0.45A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 HIS A  59
SER A  62
ILE A  87
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.28A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 0.97A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 SER A  62
GLU A  66
ILE A  87
TRP A  88
LEU A 151
 None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
 0.67A 4foxG-6aujA:
35.2		 4foxG-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 11 HIS A  59
SER A  62
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 1.13A 4foxH-6aujA:
35.2		 4foxH-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
GLU A  66
ILE A  87
TRP A  88
 None
None
PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
 0.43A 4foxH-6aujA:
35.2		 4foxH-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 11 HIS A  59
SER A  62
ILE A  87
TRP A  88
PHE A 184
 None
None
PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
PGE  A 301 (-3.7A)
 0.93A 4foxH-6aujA:
35.2		 4foxH-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.80A 4fqsA-6aujA:
35.2		 4fqsA-6aujA:
61.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 HIS A  59
ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
None
PGE  A 301 ( 4.0A)
None
 0.78A 4fqsB-6aujA:
35.1		 4fqsB-6aujA:
61.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 5 ASN A  24
MET A  23
HIS A  26
LEU A  55
 None
None
None
PGE  A 304 ( 4.4A)
 1.49A 4g5jA-5lk4A:
undetectable		 4g5jA-5lk4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.08A 4gkhB-5bwdA:
undetectable		 4gkhB-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.09A 4gkhF-5bwdA:
undetectable		 4gkhF-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 7 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.11A 4gkhG-5bwdA:
undetectable		 4gkhG-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.12A 4gkhC-5bwdA:
undetectable
4gkhK-5bwdA:
undetectable		 4gkhC-5bwdA:
15.08
4gkhK-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.09A 4gkiA-5bwdA:
undetectable		 4gkiA-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.09A 4gkiC-5bwdA:
undetectable		 4gkiC-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 8 ASP A 594
ASN A 478
GLU A 484
GLU A 598
 None
PGE  A 906 ( 4.9A)
None
None
 1.11A 4gkiE-5bwdA:
undetectable
4gkiG-5bwdA:
undetectable		 4gkiE-5bwdA:
15.08
4gkiG-5bwdA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 5 PRO A  30
ASP A  29
ILE A  59
VAL A 145
 None
None
None
PGE  A 302 ( 4.7A)
 1.28A 4hytA-4jejA:
undetectable		 4hytA-4jejA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4ld1 UNCHARACTERIZED
PROTEIN
(Danio
rerio) 		4 / 7 LYS A1022
THR A1032
THR A1040
VAL A1038
 PGE  A1202 ( 3.6A)
None
None
None
 0.96A 4ik7A-4ld1A:
undetectable		 4ik7A-4ld1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 ARG A  13
GLU A  36
ASN A  40
 PGE  A 401 (-2.8A)
PGE  A 401 (-3.9A)
PGE  A 401 (-3.8A)
 0.88A 4imaD-4nv0A:
undetectable		 4imaD-4nv0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 ARG A  13
GLU A  36
ASN A  40
 PGE  A 401 (-2.8A)
PGE  A 401 (-3.9A)
PGE  A 401 (-3.8A)
 0.84A 4ip7D-4nv0A:
undetectable		 4ip7D-4nv0A:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.58A 4iqqB-6aujA:
32.8		 4iqqB-6aujA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.53A 4iqqC-6aujA:
33.4		 4iqqC-6aujA:
43.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		6 / 12 ASP A 102
PHE A 154
LEU A 172
TYR A 209
LEU A 252
HIS A 277
 PGE  A 412 ( 4.5A)
None
None
None
None
None
 1.24A 4j03A-5nfqA:
30.3		 4j03A-5nfqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE
(metagenome) 		6 / 12 ASP A 102
TYR A 150
PHE A 154
TYR A 209
LEU A 252
HIS A 277
 PGE  A 412 ( 4.5A)
None
None
None
None
None
 0.49A 4j03A-5nfqA:
30.3		 4j03A-5nfqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4jksA-2qcvA:
35.6		 4jksA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4jksA-2qcvA:
35.6		 4jksA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4jksB-2qcvA:
35.7		 4jksB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4jksB-2qcvA:
35.7		 4jksB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4jkuA-2qcvA:
35.6		 4jkuA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.61A 4jkuA-2qcvA:
35.6		 4jkuA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4jkuB-2qcvA:
35.7		 4jkuB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.83A 4jkuB-2qcvA:
35.7		 4jkuB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 7 ARG A 509
TRP A 437
PHE A 472
GLU A 438
 None
PGE  A 601 ( 4.5A)
PGE  A 601 (-4.3A)
None
 1.03A 4jseA-5imtA:
undetectable
4jseB-5imtA:
undetectable		 4jseA-5imtA:
20.39
4jseB-5imtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 7 TRP A 437
PHE A 472
GLU A 438
ARG A 509
 PGE  A 601 ( 4.5A)
PGE  A 601 (-4.3A)
None
None
 1.07A 4jseA-5imtA:
undetectable
4jseB-5imtA:
undetectable		 4jseA-5imtA:
20.39
4jseB-5imtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 8 ARG A 255
PHE A 267
THR A 418
ARG A 474
 LYS  A 502 (-3.3A)
PGE  A 501 (-3.6A)
PGE  A 501 (-4.2A)
PGE  A 501 (-3.6A)
 0.73A 4k87A-5vl1A:
11.4		 4k87A-5vl1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4k8cA-2qcvA:
35.5		 4k8cA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4k8cA-2qcvA:
35.5		 4k8cA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4k8cB-2qcvA:
35.4		 4k8cB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.61A 4k8cB-2qcvA:
35.4		 4k8cB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4k8kA-2qcvA:
35.7		 4k8kA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4k8kA-2qcvA:
35.7		 4k8kA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4k8kB-2qcvA:
35.7		 4k8kB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4k8kB-2qcvA:
35.7		 4k8kB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.34A 4k8pA-2qcvA:
35.9		 4k8pA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.85A 4k8pA-2qcvA:
35.9		 4k8pA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4k8pB-2qcvA:
35.8		 4k8pB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.86A 4k8pB-2qcvA:
35.8		 4k8pB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4k8tA-2qcvA:
35.5		 4k8tA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.86A 4k8tA-2qcvA:
35.5		 4k8tA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4k8tB-2qcvA:
35.5		 4k8tB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.88A 4k8tB-2qcvA:
35.5		 4k8tB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4k93A-2qcvA:
35.6		 4k93A-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.87A 4k93A-2qcvA:
35.6		 4k93A-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4k93B-2qcvA:
35.7		 4k93B-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.87A 4k93B-2qcvA:
35.7		 4k93B-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4k9cA-2qcvA:
35.7		 4k9cA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.85A 4k9cA-2qcvA:
35.7		 4k9cA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.34A 4k9cB-2qcvA:
35.6		 4k9cB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.85A 4k9cB-2qcvA:
35.6		 4k9cB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4k9iA-2qcvA:
35.5		 4k9iA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.89A 4k9iA-2qcvA:
35.5		 4k9iA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4k9iB-2qcvA:
35.6		 4k9iB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.89A 4k9iB-2qcvA:
35.6		 4k9iB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.34A 4kadA-2qcvA:
35.7		 4kadA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.85A 4kadA-2qcvA:
35.7		 4kadA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4kadB-2qcvA:
32.1		 4kadB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.86A 4kadB-2qcvA:
32.1		 4kadB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4kahA-2qcvA:
35.6		 4kahA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4kahA-2qcvA:
35.6		 4kahA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4kahB-2qcvA:
35.7		 4kahB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4kahB-2qcvA:
35.7		 4kahB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4kalA-2qcvA:
35.7		 4kalA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.64A 4kalA-2qcvA:
35.7		 4kalA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4kalB-2qcvA:
35.5		 4kalB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.64A 4kalB-2qcvA:
35.5		 4kalB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4kanA-2qcvA:
35.6		 4kanA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4kanA-2qcvA:
35.6		 4kanA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 248
TYR A 241
PRO A 232
 None
PGE  A 407 (-3.5A)
None
 0.96A 4kanA-5eqvA:
2.4		 4kanA-5eqvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4kanB-2qcvA:
35.7		 4kanB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4kanB-2qcvA:
35.7		 4kanB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4kbeA-2qcvA:
35.6		 4kbeA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4kbeA-2qcvA:
35.6		 4kbeA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4kbeB-2qcvA:
35.7		 4kbeB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4kbeB-2qcvA:
35.7		 4kbeB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 285
TYR A  12
ILE A 223
THR A 258
 None
PGE  A 404 (-4.5A)
FMN  A 400 ( 4.5A)
PGE  A 404 (-3.2A)
 0.97A 4l39A-4uwmA:
0.6		 4l39A-4uwmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4lbgA-2qcvA:
35.6		 4lbgA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4lbgA-2qcvA:
35.6		 4lbgA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4lbgB-2qcvA:
35.7		 4lbgB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4lbgB-2qcvA:
35.7		 4lbgB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 248
TYR A 241
PRO A 232
 None
PGE  A 407 (-3.5A)
None
 0.97A 4lbgB-5eqvA:
undetectable		 4lbgB-5eqvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4lbxA-2qcvA:
35.6		 4lbxA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.88A 4lbxA-2qcvA:
35.6		 4lbxA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4lbxB-2qcvA:
35.7		 4lbxB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.88A 4lbxB-2qcvA:
35.7		 4lbxB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4lc4A-2qcvA:
35.6		 4lc4A-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.85A 4lc4A-2qcvA:
35.6		 4lc4A-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.37A 4lc4B-2qcvA:
35.5		 4lc4B-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
LEU A 123
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.86A 4lc4B-2qcvA:
35.5		 4lc4B-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.35A 4lcaA-2qcvA:
35.7		 4lcaA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.63A 4lcaA-2qcvA:
35.7		 4lcaA-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.36A 4lcaB-2qcvA:
35.5		 4lcaB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  43
GLY A  44
ASN A  48
ILE A 113
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.62A 4lcaB-2qcvA:
35.5		 4lcaB-2qcvA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 124
ASP A 134
ARG A 496
LEU A 139
ILE A 150
 None
None
None
PGE  A 777 ( 4.9A)
PGE  A 777 ( 4.7A)
 1.05A 4m2xE-2f3oA:
undetectable		 4m2xE-2f3oA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 SER A  55
MET A  57
ASP A 162
 None
PGE  A 364 ( 3.8A)
None
 0.93A 4mm4B-2rb7A:
undetectable		 4mm4B-2rb7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.51A 4n09A-2qcvA:
31.1		 4n09A-2qcvA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.55A 4n09B-2qcvA:
31.2		 4n09B-2qcvA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.54A 4n09C-2qcvA:
31.1		 4n09C-2qcvA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.56A 4n09D-2qcvA:
30.9		 4n09D-2qcvA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3oqq PUTATIVE LIPOPROTEIN
(Bacteroides
ovatus) 		4 / 6 LEU A 320
ASP A 293
VAL A 324
ALA A 231
 None
PGE  A 462 ( 4.4A)
None
None
 1.02A 4nkxA-3oqqA:
undetectable		 4nkxA-3oqqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 VAL A 296
LEU A 300
LEU A 336
PHE A 348
 None
None
PGE  A 502 (-4.7A)
EGR  A 501 ( 4.7A)
 1.09A 4o1zA-4j0kA:
undetectable		 4o1zA-4j0kA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2f3o PYRUVATE
FORMATE-LYASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 440
THR A 148
SER A 438
HIS A 155
 GOL  A 778 (-4.0A)
PGE  A 777 ( 4.4A)
None
GOL  A 778 (-4.3A)
 1.42A 4o4dA-2f3oA:
undetectable		 4o4dA-2f3oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3dxo UNCHARACTERIZED
SNOAL-LIKE PROTEIN
(Agrobacterium
fabrum) 		4 / 8 LEU A  12
ASN A  16
MET A  53
MET A  42
 None
None
None
PGE  A 121 ( 4.3A)
 1.03A 4ok1A-3dxoA:
undetectable		 4ok1A-3dxoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 ASN B 504
ILE B 464
ILE B 465
VAL B 454
 PGE  B 604 (-4.0A)
None
None
None
 0.99A 4olmA-5jjdB:
undetectable		 4olmA-5jjdB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.77A 4qa0B-5lk4A:
undetectable		 4qa0B-5lk4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.78A 4qa0A-5lk4A:
undetectable		 4qa0A-5lk4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5lk4 MSCARLET
(Discosoma
sp.) 		3 / 3 PRO A 191
MET A 190
TYR A  83
 None
PGE  A 303 (-3.6A)
None
 0.83A 4qa2B-5lk4A:
undetectable		 4qa2B-5lk4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4q3k MGS-M1
(unidentified) 		4 / 8 LEU A 195
PRO A 177
VAL A 172
HIS A 201
 None
None
PGE  A 303 ( 4.6A)
None
 1.13A 4qknA-4q3kA:
undetectable		 4qknA-4q3kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 11 GLY A 134
GLY A 135
GLY A 218
ILE A 224
PHE A 427
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
None
1PE  A1553 (-4.7A)
 1.15A 4qoiA-4be9A:
undetectable
4qoiB-4be9A:
2.2		 4qoiA-4be9A:
16.76
4qoiB-4be9A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 PHE A 141
ILE A 243
THR A 233
SER A 239
LEU A 240
 None
None
PGE  A1003 (-4.0A)
None
None
 1.26A 4qztC-4p8iA:
undetectable		 4qztC-4p8iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 103
ILE A  56
PHE A  77
LEU A  63
LEU A  87
 None
SO4  A 404 (-4.1A)
PGE  A 408 ( 4.7A)
None
None
 0.93A 4rz7A-4iiwA:
undetectable		 4rz7A-4iiwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.32A 4ubeA-2qcvA:
31.6		 4ubeA-2qcvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4kry ACETYL ESTERASE
(Escherichia
coli) 		3 / 3 MET A  64
GLN A 133
TYR A  69
 PGE  A 402 (-4.2A)
None
None
 0.89A 4udcA-4kryA:
undetectable		 4udcA-4kryA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 SER A 148
LEU A 154
PRO A 156
VAL A 129
THR A 127
 OCS  A 149 ( 3.5A)
None
None
None
PGE  A 402 (-4.7A)
 1.23A 4uuuB-5ur0A:
undetectable		 4uuuB-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 5 PHE A 119
PRO A 134
VAL A 135
ALA A 131
 PGE  A 278 ( 4.7A)
None
None
None
 1.30A 4w5oA-3p77A:
undetectable		 4w5oA-3p77A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Mus
musculus) 		4 / 5 PHE A  40
PRO A 143
VAL A 141
ALA A  41
 PGE  A 401 ( 3.5A)
None
None
None
 1.29A 4w5oA-4zw2A:
4.3		 4w5oA-4zw2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2it9 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 6 LEU A  89
LEU A  91
GLU A 102
ILE A  31
 None
None
PGE  A 128 (-3.7A)
None
 0.97A 4ww7A-2it9A:
undetectable		 4ww7A-2it9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 12 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.09A 4x1iD-3berA:
2.5		 4x1iD-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 11 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.14A 4x20D-3berA:
undetectable		 4x20D-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3lvv GLUTAMATE--CYSTEINE
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 256
VAL A 316
GLY A 163
SER A 257
MET A 262
 None
None
PGE  A 698 (-4.4A)
None
LBP  A 693 (-3.6A)
 1.40A 4xpbA-3lvvA:
undetectable		 4xpbA-3lvvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 5 PHE A 119
PRO A 134
VAL A 135
ALA A 131
 PGE  A 278 ( 4.7A)
None
None
None
 1.30A 4z4cA-3p77A:
undetectable		 4z4cA-3p77A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Mus
musculus) 		4 / 5 PHE A  40
PRO A 143
VAL A 141
ALA A  41
 PGE  A 401 ( 3.5A)
None
None
None
 1.25A 4z4cA-4zw2A:
undetectable		 4z4cA-4zw2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 5 PHE A 176
PRO A 178
VAL A 157
PHE A 425
 None
PGE  A 703 ( 4.9A)
None
PGE  A 703 ( 4.4A)
 1.31A 4z4cA-5verA:
undetectable		 4z4cA-5verA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 5 PHE A 119
PRO A 134
VAL A 135
ALA A 131
 PGE  A 278 ( 4.7A)
None
None
None
 1.32A 4z4dA-3p77A:
undetectable		 4z4dA-3p77A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Mus
musculus) 		4 / 5 PHE A  40
PRO A 143
VAL A 141
ALA A  41
 PGE  A 401 ( 3.5A)
None
None
None
 1.31A 4z4dA-4zw2A:
undetectable		 4z4dA-4zw2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3p77 MHC RFP-Y CLASS I
ALPHA CHAIN
(Gallus
gallus) 		4 / 5 PHE A 119
PRO A 134
VAL A 135
ALA A 131
 PGE  A 278 ( 4.7A)
None
None
None
 1.32A 4z4eA-3p77A:
undetectable		 4z4eA-3p77A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Mus
musculus) 		4 / 5 PHE A  40
PRO A 143
VAL A 141
ALA A  41
 PGE  A 401 ( 3.5A)
None
None
None
 1.30A 4z4eA-4zw2A:
undetectable		 4z4eA-4zw2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3g5j PUTATIVE ATP/GTP
BINDING PROTEIN
(Clostridioides
difficile) 		5 / 12 GLY A 119
TYR A  52
ILE A  51
PHE A  40
GLY A  64
 None
None
None
None
PGE  A 302 ( 4.0A)
 0.98A 4ze2A-3g5jA:
undetectable		 4ze2A-3g5jA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 501
LEU A 149
ILE A 469
GLY A 218
THR A 494
 None
None
PGE  A1554 ( 4.7A)
None
None
 1.16A 4ze2A-4be9A:
undetectable		 4ze2A-4be9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 11 PHE A  63
GLY A  32
GLY A  33
MET A  55
ILE A   5
 PGE  A 301 (-4.3A)
PGE  A 301 (-3.6A)
None
PGE  A 301 ( 4.4A)
None
 1.23A 4zvmA-4r9xA:
undetectable
4zvmB-4r9xA:
undetectable		 4zvmA-4r9xA:
21.20
4zvmB-4r9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 8 SER A 225
GLY A 222
ILE A 313
GLY A 134
 None
None
1PE  A1553 (-4.7A)
PGE  A1554 ( 4.7A)
 0.86A 5alcL-4be9A:
undetectable		 5alcL-4be9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 6 SER A 216
GLU A 223
GLY A 321
GLY A 199
 None
None
None
PGE  A 390 ( 4.4A)
 0.84A 5cdnA-3r9pA:
undetectable
5cdnB-3r9pA:
undetectable		 5cdnA-3r9pA:
23.90
5cdnB-3r9pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 6 SER A 216
GLU A 223
GLY A 321
GLY A 199
 None
None
None
PGE  A 390 ( 4.4A)
 0.90A 5cdnR-3r9pA:
undetectable
5cdnS-3r9pA:
undetectable		 5cdnR-3r9pA:
23.90
5cdnS-3r9pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4ovk PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 LEU A 347
ARG A 332
PHE A 342
TYR A 184
TYR A 345
 None
None
None
PGE  A 401 (-3.6A)
None
 1.37A 5czyA-4ovkA:
undetectable		 5czyA-4ovkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 8 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.97A 5dzkd-3eqxA:
undetectable
5dzkr-3eqxA:
undetectable		 5dzkd-3eqxA:
18.85
5dzkr-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR
(Shewanella
oneidensis) 		4 / 8 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.77A 5dzkF-3eqxA:
undetectable
5dzkT-3eqxA:
undetectable		 5dzkF-3eqxA:
18.85
5dzkT-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 501
LEU A 149
ILE A 469
GLY A 218
THR A 494
 None
None
PGE  A1554 ( 4.7A)
None
None
 1.18A 5eskA-4be9A:
undetectable		 5eskA-4be9A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.57A 5h3aB-6aujA:
34.1		 5h3aB-6aujA:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_H_BBIH405_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN
(Homo
sapiens) 		4 / 4 ARG B 442
GLU B 446
PHE B 579
VAL B 525
 PGE  B 604 ( 3.5A)
PGE  B 604 ( 3.4A)
PGE  B 604 (-2.7A)
PGE  B 604 ( 4.6A)
 1.34A 5h4dH-5jjdB:
0.0		 5h4dH-5jjdB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Clostridium
beijerinckii;
Thermoanaerobact
er
brockii) 		5 / 12 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
None
PGE  A 357 (-4.5A)
None
None
 1.18A 5ih0A-3fplA:
undetectable		 5ih0A-3fplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3mvk PROTEIN FUCU
(Bifidobacterium
longum) 		3 / 3 GLY A  21
ASP A  24
ASN A 121
 None
PGE  A 151 (-4.3A)
None
 0.60A 5jglA-3mvkA:
2.3		 5jglA-3mvkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3oqq PUTATIVE LIPOPROTEIN
(Bacteroides
ovatus) 		5 / 12 ALA A 231
ILE A 453
TYR A 455
GLY A 207
THR A 291
 None
None
None
CA  A 457 (-3.7A)
PGE  A 462 (-3.4A)
 1.36A 5jlcA-3oqqA:
undetectable		 5jlcA-3oqqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3kw8 PUTATIVE COPPER
OXIDASE
(Streptomyces
coelicolor) 		4 / 5 ILE A  89
LEU A  78
HIS A 154
VAL A 103
 None
PGE  A 612 (-4.8A)
None
None
 1.16A 5jmnB-3kw8A:
undetectable		 5jmnB-3kw8A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gyb COPPER OXIDASE
(Streptomyces
lividans) 		4 / 5 ILE A  89
LEU A  78
HIS A 154
VAL A 103
 None
PGE  A 409 (-4.9A)
None
None
 1.20A 5jmnB-4gybA:
undetectable		 5jmnB-4gybA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE
(Paenibacillus
macerans) 		3 / 3 LYS A 302
ASP A 303
ARG A 437
 PGE  A 730 (-3.0A)
None
None
 1.00A 5jwaA-4jclA:
undetectable
5jwaH-4jclA:
undetectable		 5jwaA-4jclA:
21.04
5jwaH-4jclA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		6 / 12 ASP A  22
GLY A  43
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
None
PGE  A 332 (-3.6A)
 0.40A 5kb5A-2qcvA:
30.9		 5kb5A-2qcvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE A 236
SER A 237
ASN A 185
ASP A 257
 PGE  A 501 (-3.5A)
None
EDO  A 507 ( 4.7A)
None
 1.47A 5kpcA-4gl0A:
undetectable		 5kpcA-4gl0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA
(Escherichia
coli;
Salmonella
enterica) 		4 / 6 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
None
None
PGE  A 502 (-4.4A)
 1.25A 5ljeA-4exkA:
undetectable		 5ljeA-4exkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5gjn LYSINE/ORNITHINE
DECARBOXYLASE
(Selenomonas
ruminantium) 		5 / 10 HIS A 210
ARG A 112
HIS A 172
LEU A 134
THR A 212
 None
PGE  A 406 (-3.9A)
None
None
None
 1.27A 5m8nB-5gjnA:
undetectable		 5m8nB-5gjnA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5lk4 MSCARLET
(Discosoma
sp.) 		4 / 6 THR A 148
ARG A 150
ASP A 161
GLY A 160
 PGE  A 306 (-4.7A)
PO4  A 302 (-3.0A)
None
None
 0.95A 5mraA-5lk4A:
undetectable
5mraB-5lk4A:
undetectable		 5mraA-5lk4A:
20.72
5mraB-5lk4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 ALA A 258
GLN A 250
THR A 246
 None
PGE  A 288 ( 3.5A)
None
 0.61A 5n0oA-3iehA:
undetectable		 5n0oA-3iehA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0rA-3iehA:
undetectable		 5n0rA-3iehA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0sA-3iehA:
1.5		 5n0sA-3iehA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4c76 FMN REDUCTASE
(NADPH)
(Pseudomonas
putida) 		4 / 4 GLY A 145
ALA A 114
MET A 125
THR A  21
 PGE  A 206 (-4.7A)
None
None
None
 1.43A 5n0sB-4c76A:
undetectable		 5n0sB-4c76A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0wA-3iehA:
undetectable		 5n0wA-3iehA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3bs6 INNER MEMBRANE
PROTEIN OXAA
(Escherichia
coli) 		3 / 3 THR A 306
HIS A 267
ASN A 304
 None
None
PGE  A 338 (-3.4A)
 0.91A 5n4tA-3bs6A:
undetectable		 5n4tA-3bs6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 LEU A 225
HIS A 173
GLY A 199
GLY A 228
HIS A 169
 None
None
PGE  A 390 ( 4.4A)
None
PGE  A 390 (-3.9A)
 1.24A 5nnaB-3r9pA:
undetectable		 5nnaB-3r9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 500
GLY A 563
ASP A 501
ASN A 561
 PGE  A1684 ( 3.8A)
None
None
None
 0.96A 5nnwD-3zukA:
undetectable		 5nnwD-3zukA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 500
GLY A 563
ASP A 501
ASN A 561
 PGE  A1684 ( 3.8A)
None
None
None
 0.97A 5no9D-3zukA:
undetectable		 5no9D-3zukA:
8.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.58A 5nooA-6aujA:
33.6		 5nooA-6aujA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.54A 5nooB-6aujA:
33.4		 5nooB-6aujA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 6 ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.45A 5nooC-6aujA:
33.3		 5nooC-6aujA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 6 ASP A 177
LEU A 180
GLY A 181
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
None
 0.98A 5nooC-6aujA:
33.3		 5nooC-6aujA:
43.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 12 GLY A  52
SER A  53
LYS A  55
GLU A 174
LEU A 142
 None
None
None
PGE  A 332 (-3.0A)
None
 0.95A 5nwwA-2qcvA:
undetectable		 5nwwA-2qcvA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 8 VAL E 124
ILE E  96
ALA E 109
LEU E 114
 PGE  E 402 (-4.9A)
None
None
None
 0.78A 5og9A-6bm7E:
undetectable		 5og9A-6bm7E:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC
(Bordetella
pertussis) 		4 / 6 THR A 279
ARG A 280
LEU A 281
ASP A 282
 None
P6G  A 609 (-2.8A)
None
PGE  A 601 ( 4.6A)
 1.07A 5tdzA-4ql0A:
undetectable		 5tdzA-4ql0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 6 TYR A  55
LEU A 204
PHE A 202
LEU A  53
 None
None
None
PGE  A 503 ( 3.7A)
 1.18A 5tl8A-4ogzA:
undetectable		 5tl8A-4ogzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 ARG A 256
TYR A 135
GLU A 315
SER A 313
 PEG  A1477 (-4.4A)
PGE  A1479 (-4.4A)
PGE  A1479 (-3.2A)
PEG  A1477 ( 4.4A)
 1.10A 5umwA-5g0aA:
undetectable
5umwF-5g0aA:
undetectable		 5umwA-5g0aA:
10.13
5umwF-5g0aA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3r7t ADENYLOSUCCINATE
SYNTHETASE
(Campylobacter
jejuni) 		5 / 12 ASP A 282
LEU A 325
VAL A 262
TYR A 389
TYR A 364
 PGE  A 422 ( 4.9A)
None
None
None
None
 1.07A 5uxdB-3r7tA:
undetectable		 5uxdB-3r7tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG
(Escherichia
coli;
Pseudomonas
phage
JBD30) 		3 / 3 ASP A 376
ASN A  98
ASP A  43
 None
PGE  A 503 (-4.3A)
PGE  A 503 ( 4.4A)
 0.90A 5vopB-6anvA:
undetectable		 5vopB-6anvA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.43A 5vscA-3r9pA:
undetectable		 5vscA-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vscB-3r9pA:
undetectable		 5vscB-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vseA-3r9pA:
undetectable		 5vseA-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vseB-3r9pA:
undetectable		 5vseB-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.96A 5wbvA-5brrE:
undetectable		 5wbvA-5brrE:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.96A 5wbvB-5brrE:
undetectable		 5wbvB-5brrE:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 8 PRO A 491
THR A 493
TYR A 529
PRO A 673
 PGE  A 801 (-4.0A)
None
None
None
 1.08A 5x2sI-4ioxA:
undetectable
5x2sJ-4ioxA:
undetectable
5x2sK-4ioxA:
undetectable		 5x2sI-4ioxA:
23.91
5x2sJ-4ioxA:
19.77
5x2sK-4ioxA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 GLU A  66
ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 (-4.1A)
PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.69A 5x5qB-6aujA:
33.9		 5x5qB-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 7 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.56A 5x5qC-6aujA:
34.3		 5x5qC-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 8 ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.38A 5x5qD-6aujA:
34.3		 5x5qD-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 8 ILE A  87
ASP A 177
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 (-3.7A)
None
 0.57A 5x5qD-6aujA:
34.3		 5x5qD-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		4 / 8 ASP A 177
GLY A 181
PHE A 184
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.38A 5x5qF-6aujA:
34.3		 5x5qF-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 ASP A 177
LEU A 180
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.52A 5x66A-6aujA:
34.2
5x66B-6aujA:
34.2		 5x66A-6aujA:
51.54
5x66B-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 12 ILE A  87
ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.59A 5x66A-6aujA:
34.2
5x66B-6aujA:
34.2		 5x66A-6aujA:
51.54
5x66B-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		6 / 9 ASP A 177
LEU A 180
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.59A 5x66C-6aujA:
34.2		 5x66C-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 9 ILE A  87
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.52A 5x66C-6aujA:
34.2		 5x66C-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 10 ASP A 177
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.43A 5x66D-6aujA:
34.2		 5x66D-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 10 ILE A  87
GLY A 181
PHE A 184
ASN A 185
TYR A 217
 PGE  A 301 ( 4.2A)
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
PGE  A 301 ( 4.9A)
None
 0.53A 5x66D-6aujA:
34.2		 5x66D-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ASP A 177
LEU A 180
GLY A 181
PHE A 184
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.65A 5x66F-6aujA:
34.1		 5x66F-6aujA:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
 PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
 0.66A 5x66F-6aujA:
34.1		 5x66F-6aujA:
51.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 500
GLY A 496
GLU A 494
ASN A 452
HIS A 493
 PGE  A1684 ( 3.8A)
None
RDF  A1665 (-2.5A)
RDF  A1665 (-3.2A)
ZN  A1664 ( 3.4A)
 1.32A 5x7pB-3zukA:
0.7		 5x7pB-3zukA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4xwl EXOGLUCANASE S
(Clostridium
cellulovorans) 		3 / 3 GLU A  46
TRP A 149
HIS A  31
 None
PGE  A 712 ( 3.8A)
None
 0.74A 5xipA-4xwlA:
undetectable		 5xipA-4xwlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z1s HYPOTHETICAL PROTEIN
PA3332
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  84
LEU A  62
PHE A  66
LEU A   7
TYR A 115
 None
None
PGE  A 301 (-4.8A)
None
PGE  A 301 (-4.6A)
 1.21A 5y2oA-1z1sA:
0.3		 5y2oA-1z1sA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5it6 GALECTIN-RELATED
PROTEIN
(Gallus
gallus) 		5 / 12 GLY A 128
SER A  30
PHE A  80
PHE A  88
VAL A  90
 PGE  A 205 (-2.9A)
PGE  A 205 (-2.8A)
None
None
None
 1.26A 6a94A-5it6A:
undetectable		 6a94A-5it6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4wmd ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 TYR A  54
HIS A  41
MET A 168
 None
PGE  A 402 ( 4.2A)
PGE  A 402 ( 4.8A)
 1.03A 6af6A-4wmdA:
undetectable		 6af6A-4wmdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3kkg PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE
(Jannaschia
sp.
CCS1) 		5 / 12 LEU A 159
LEU A 126
THR A 157
GLY A 119
LEU A  97
 None
PGE  A 204 (-4.2A)
PEG  A 202 ( 4.7A)
None
None
 1.14A 6b0lB-3kkgA:
undetectable		 6b0lB-3kkgA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 MET A 190
ILE A 189
ASP A 194
THR A  72
THR A  17
 PGE  A 403 (-3.8A)
None
None
None
None
 1.41A 6b4yA-5w76A:
2.3		 6b4yA-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 PRO A 193
SER A 213
VAL A  41
PHE A  99
PHE A  89
 None
RMN  A 401 (-2.5A)
None
PGE  A 402 ( 4.5A)
None
 1.03A 6behA-4p56A:
undetectable
6behB-4p56A:
undetectable
6behC-4p56A:
undetectable		 6behA-4p56A:
20.95
6behB-4p56A:
20.95
6behC-4p56A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		5 / 9 ALA A 277
SER A 276
VAL A 302
ALA A 299
SER A 298
 None
None
None
PGE  A 332 (-3.6A)
None
 0.94A 6bklA-2qcvA:
undetectable
6bklB-2qcvA:
undetectable
6bklC-2qcvA:
undetectable
6bklD-2qcvA:
undetectable		 6bklA-2qcvA:
5.17
6bklB-2qcvA:
5.17
6bklC-2qcvA:
5.17
6bklD-2qcvA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		7 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLY A 471
ARG A 474
ILE A 484
 LYS  A 502 (-3.3A)
None
PGE  A 501 (-4.8A)
PGE  A 501 (-3.6A)
PGE  A 501 ( 4.4A)
PGE  A 501 (-3.6A)
None
 0.77A 6bniA-5vl1A:
43.4		 6bniA-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 GLU A 257
HIS A 263
GLU A 415
ARG A 474
ILE A 484
 None
PGE  A 501 (-4.8A)
PGE  A 501 (-4.1A)
PGE  A 501 (-3.6A)
None
 0.93A 6bniA-5vl1A:
43.4		 6bniA-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		7 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLY A 471
ARG A 474
ILE A 484
 LYS  A 502 (-3.3A)
None
PGE  A 501 (-4.8A)
PGE  A 501 (-3.6A)
PGE  A 501 ( 4.4A)
PGE  A 501 (-3.6A)
None
 0.79A 6bniB-5vl1A:
43.3		 6bniB-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 GLU A 257
HIS A 263
GLU A 415
ARG A 474
ILE A 484
 None
PGE  A 501 (-4.8A)
PGE  A 501 (-4.1A)
PGE  A 501 (-3.6A)
None
 0.93A 6bniB-5vl1A:
43.3		 6bniB-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE
(Bacillus
halodurans) 		4 / 6 ALA A 277
SER A 276
ALA A 299
SER A 298
 None
None
PGE  A 332 (-3.6A)
None
 0.79A 6bocA-2qcvA:
undetectable
6bocB-2qcvA:
undetectable
6bocC-2qcvA:
undetectable
6bocD-2qcvA:
undetectable		 6bocA-2qcvA:
5.17
6bocB-2qcvA:
5.17
6bocC-2qcvA:
5.17
6bocD-2qcvA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 LEU A 102
TYR A 134
GLU A 180
THR A 151
 PGE  A 302 ( 3.7A)
PGE  A 302 ( 4.0A)
1GP  A 301 (-2.1A)
PO4  A 303 (-4.0A)
 1.13A 6c71B-4jejA:
undetectable		 6c71B-4jejA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 VAL A  90
PHE A  99
GLU A 134
LEU A 140
ILE A 143
 None
PGE  A 402 ( 4.5A)
None
None
None
 1.25A 6d9hR-4p56A:
undetectable		 6d9hR-4p56A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 8 GLY A  43
GLN A  45
SER A 113
TRP A 147
 F  A 302 (-3.4A)
None
F  A 302 (-2.5A)
PGE  A 303 ( 4.6A)
 0.97A 6eqpA-4q3kA:
18.6		 6eqpA-4q3kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4ubs PENTALENIC ACID
SYNTHASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 131
GLU A 142
ALA A 141
LEU A 372
LEU A 368
 PGE  A 507 ( 4.3A)
None
None
None
None
 1.09A 6f6iA-4ubsA:
undetectable
6f6iB-4ubsA:
undetectable		 6f6iA-4ubsA:
10.69
6f6iB-4ubsA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 11 ASP A 126
PHE A 129
ILE A 132
ILE A  87
MET A  91
 PGE  A 219 (-3.8A)
None
None
None
None
 1.42A 6fgcA-3sd7A:
2.0		 6fgcA-3sd7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6f9m SERINE PROTEASE
(Planococcus
plakortidis) 		4 / 6 LEU A 247
TYR A   9
VAL A 204
GLY A  85
 None
None
PGE  A 401 (-4.5A)
None
 1.02A 6hd4B-6f9mA:
undetectable		 6hd4B-6f9mA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 SER C1180
ARG C1084
THR C1058
ALA C1272
 None
None
None
PGE  C1601 ( 4.4A)
 0.99A 6ma6A-5swvC:
undetectable		 6ma6A-5swvC:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bgu MALATE DEHYDROGENASE
(Haloferax
volcanii) 		4 / 7 ASP A 137
ARG A 138
TYR A 131
ASP A 252
 CL  A1324 (-3.9A)
None
PGE  A1341 ( 3.9A)
None
 0.90A 6mn5B-4bguA:
undetectable		 6mn5B-4bguA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 1.05A 6nmpC-6c0tA:
2.1
6nmpJ-6c0tA:
undetectable		 6nmpC-6c0tA:
undetectable
6nmpJ-6c0tA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ASP A 177
LEU A 180
GLY A 181
ASN A 185
TYR A 217
 None
None
PGE  A 301 ( 4.0A)
PGE  A 301 ( 4.9A)
None
 0.60A 6r2eA-6aujA:
33.1		 6r2eA-6aujA:
48.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ILE A  87
TRP A  88
TYR A 102
LEU A 151
ASN A 185
 PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
None
PGE  A 301 ( 4.9A)
 0.87A 6r2eE-6aujA:
33.0		 6r2eE-6aujA:
48.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6auj THYMIDYLATE SYNTHASE
(Elizabethkingia
anophelis) 		5 / 12 ILE A  87
TRP A  88
TYR A 102
LEU A 151
ASN A 185
 PGE  A 301 ( 4.2A)
PGE  A 301 (-3.5A)
None
None
PGE  A 301 ( 4.9A)
 0.68A 6r2eH-6aujA:
33.0		 6r2eH-6aujA:
48.16