SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PG6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 PHE A 125
LEU A  75
TYR A  37
LEU A  96
LEU A  87
 PG6  A 163 ( 4.2A)
PG6  A 163 ( 4.8A)
None
None
None
 1.35A 1e7wA-3eeaA:
undetectable		 1e7wA-3eeaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 11 SER A 282
SER A 285
TYR A 288
GLU A 143
GLY A 142
 None
PG6  A 299 ( 4.2A)
PG6  A 299 ( 3.8A)
None
None
 1.40A 1i9jH-3jr7A:
undetectable
1i9jL-3jr7A:
undetectable		 1i9jH-3jr7A:
20.26
1i9jL-3jr7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE
(Tenebrio
molitor) 		5 / 12 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
 PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
 1.15A 1nbhA-3qt4A:
undetectable		 1nbhA-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE
(Tenebrio
molitor) 		5 / 12 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
 PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
 1.15A 1nbhD-3qt4A:
undetectable		 1nbhD-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 5 LEU A 108
ALA A 106
LEU A 104
SER A 111
 PG6  A 299 (-4.3A)
None
PG6  A 299 ( 4.6A)
None
 1.09A 1tt6B-3jr7A:
undetectable		 1tt6B-3jr7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 LEU A  67
VAL A  29
VAL A 109
ILE A  34
 PG6  A 163 ( 4.9A)
None
None
None
 1.00A 2hyyA-3eeaA:
undetectable		 2hyyA-3eeaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116
(Vibrio
parahaemolyticus) 		5 / 12 TYR A 104
LEU A 108
ILE A 111
THR A  88
ASP A  10
 PG6  A 209 (-4.1A)
None
None
None
None
 1.43A 2qo4A-3kzqA:
undetectable		 2qo4A-3kzqA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 152
GLN A 144
PHE A  61
PHE A  96
 None
PG6  A 301 (-4.1A)
None
None
 0.95A 2qx6A-4rajA:
undetectable
2qx6B-4rajA:
undetectable		 2qx6A-4rajA:
22.43
2qx6B-4rajA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A  61
LEU A  79
ILE A  72
LEU A 103
ASP A  45
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 (-4.7A)
None
 1.06A 3hecA-3eeaA:
undetectable		 3hecA-3eeaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		4 / 8 GLU A  31
SER A 138
THR A 176
ALA A 252
 None
PG6  A 299 ( 4.7A)
PG6  A 299 ( 4.2A)
None
 0.99A 3ns1L-3jr7A:
undetectable		 3ns1L-3jr7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116
(Vibrio
parahaemolyticus) 		4 / 8 TYR A 104
VAL A   8
CYH A  16
TYR A   7
 PG6  A 209 (-4.1A)
None
None
None
 1.32A 4bqtC-3kzqA:
undetectable
4bqtD-3kzqA:
undetectable		 4bqtC-3kzqA:
23.58
4bqtD-3kzqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 GLN A 144
PHE A  61
PHE A  96
GLY A 152
 PG6  A 301 (-4.1A)
None
None
None
 0.90A 4fgjA-4rajA:
undetectable
4fgjB-4rajA:
undetectable		 4fgjA-4rajA:
22.22
4fgjB-4rajA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ILE A  72
ALA A 111
LEU A  96
LEU A  87
PHE A 125
 PG6  A 163 (-4.4A)
None
None
None
PG6  A 163 ( 4.2A)
 1.18A 4pbhA-3eeaA:
undetectable		 4pbhA-3eeaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307
([Ruminococcus]
gnavus) 		5 / 12 GLU A 258
GLU A 257
GLU A 262
GLY A 293
ALA A 289
 None
None
None
None
PG6  A 299 ( 4.6A)
 1.26A 4xe5A-3jr7A:
undetectable		 4xe5A-3jr7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116
(Vibrio
parahaemolyticus) 		4 / 5 PRO A 122
HIS A 113
LEU A 137
TYR A 104
 None
None
None
PG6  A 209 (-4.1A)
 1.47A 5igjA-3kzqA:
undetectable		 5igjA-3kzqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4f7f AGAP005208-PA
(Anopheles
gambiae) 		5 / 12 GLY A  80
ALA A  79
ASP A  76
SER A  66
ILE A  70
 None
None
None
PG6  A 202 ( 4.4A)
PG6  A 202 ( 4.9A)
 1.03A 5t2zA-4f7fA:
undetectable		 5t2zA-4f7fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A  96
PHE A 135
ILE A  72
ALA A  35
ILE A  34
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 ( 4.3A)
None
 0.72A 5veuB-3eeaA:
undetectable		 5veuB-3eeaA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ha4 BETA-GALACTOSIDASE
(Acidilobus
saccharovorans) 		5 / 12 ILE A 418
GLY A 419
ILE A 147
MET A 202
LEU A 366
 PG6  A 510 ( 4.9A)
None
None
PG6  A 510 (-3.4A)
None
 1.00A 5ycnA-4ha4A:
undetectable		 5ycnA-4ha4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 111
LEU A 131
GLY A  99
ALA A  98
LEU A 137
 None
None
PG6  A 209 (-4.0A)
None
None
 1.02A 5zwrA-3kzqA:
undetectable		 5zwrA-3kzqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4f7f AGAP005208-PA
(Anopheles
gambiae) 		4 / 4 GLY A  30
ARG A  14
ASN A  29
LEU A  31
 None
PG6  A 202 (-3.9A)
None
None
 1.43A 6b58A-4f7fA:
undetectable		 6b58A-4f7fA:
10.24