SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PG0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4pt1 ODORANT-BINDING
PROTEIN 1D
(Locusta
migratoria) 		4 / 7 PHE A  67
LEU A  73
GLY A  84
ILE A 106
 None
None
PG0  A 201 ( 4.1A)
None
 0.80A 1p2yA-4pt1A:
undetectable		 1p2yA-4pt1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 PHE A 205
LEU A  50
PHE A 103
SER A   3
 None
None
None
PG0  A 303 (-3.6A)
 1.18A 1wrlC-5eyiA:
undetectable		 1wrlC-5eyiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5eyi NON-STRUCTURAL
PROTEIN 11
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 TYR A  69
GLY A 106
PHE A  76
 PG0  A 303 (-4.2A)
None
None
 0.59A 2m2pB-5eyiA:
undetectable		 2m2pB-5eyiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 TRP A1606
GLY A1406
SER A1357
VAL A1359
ASN A1378
 None
PG0  A1703 ( 4.5A)
None
None
None
 1.48A 3hiiA-5uqdA:
undetectable		 3hiiA-5uqdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 TRP A1606
GLY A1406
SER A1357
VAL A1359
ASN A1378
 None
PG0  A1703 ( 4.5A)
None
None
None
 1.47A 3hiiB-5uqdA:
undetectable		 3hiiB-5uqdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5ej0 ENVELOPE PROTEIN H3
(Vaccinia
virus) 		5 / 12 VAL A  11
HIS A 101
PHE A 110
THR A 194
ARG A 227
 None
None
None
PG0  A 705 (-3.1A)
EOH  A 718 (-4.1A)
 1.32A 3j6pB-5ej0A:
undetectable		 3j6pB-5ej0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.00A 3k2hA-5uqdA:
undetectable		 3k2hA-5uqdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.16A 3nrrA-5uqdA:
undetectable		 3nrrA-5uqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		5 / 12 LEU A1227
ARG A1276
THR A1249
ILE A1251
LEU A1287
 None
PG0  A1704 (-3.8A)
None
None
None
 1.09A 3nrrB-5uqdA:
undetectable		 3nrrB-5uqdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4mad BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 GLN A 542
ARG A  28
ALA A 285
GLY A 284
ASN A 286
 None
None
None
None
PG0  A 900 ( 4.7A)
 1.20A 3v3oA-4madA:
undetectable		 3v3oA-4madA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 4mad BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 VAL A 207
ASN A 208
CYH A 231
TYR A 450
SER A 160
 None
None
None
PG0  A 900 (-3.7A)
None
 1.33A 4po0A-4madA:
undetectable		 4po0A-4madA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4mad BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 GLU A 233
TYR A 299
GLU A  98
 None
None
PG0  A 900 (-3.2A)
 0.82A 4ryaA-4madA:
undetectable		 4ryaA-4madA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5uqd DUMPY: SHORTER THAN
WILD-TYPE
(Caenorhabditis
elegans) 		4 / 5 ILE A1408
PHE A1586
SER A1403
ASP A1454
 PG0  A1703 (-4.2A)
None
None
FE2  A1702 (-2.6A)
 1.32A 4rzvB-5uqdA:
undetectable		 4rzvB-5uqdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4mad BETA-GALACTOSIDASE
(Bacillus
circulans) 		6 / 12 TYR A  52
CYH A  96
GLU A  98
GLU A 157
GLU A 233
TYR A 271
 None
PG0  A 900 ( 4.6A)
PG0  A 900 (-3.2A)
None
None
None
 0.79A 5gsmA-4madA:
35.4		 5gsmA-4madA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4mad BETA-GALACTOSIDASE
(Bacillus
circulans) 		6 / 12 TYR A  52
CYH A  96
GLU A  98
GLU A 157
GLU A 233
TYR A 271
 None
PG0  A 900 ( 4.6A)
PG0  A 900 (-3.2A)
None
None
None
 0.79A 5gsmB-4madA:
36.2		 5gsmB-4madA:
25.68