SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PEU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4r4k UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 7 THR A  51
PHE A  50
PHE A  43
LEU A 135
 None
None
ACT  A 202 ( 4.9A)
PEU  A 204 ( 4.0A)
 1.13A 1qcaA-4r4kA:
undetectable		 1qcaA-4r4kA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)
(Chaetomium) 		3 / 3 SER A  62
GLY A  63
ARG A 104
 None
PEU  A 402 ( 4.6A)
None
 0.62A 1t9wA-4xvhA:
undetectable		 1t9wA-4xvhA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.87A 2wa2B-5xg9B:
undetectable		 2wa2B-5xg9B:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)
(Chaetomium) 		3 / 3 ARG A 246
ASP A 140
GLN A 320
 None
PEU  A 402 ( 4.2A)
None
 0.88A 3lcvB-4xvhA:
undetectable		 3lcvB-4xvhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)
(Chaetomium) 		4 / 6 THR A 237
ASN A 238
GLY A 188
ILE A 233
 None
PEU  A 402 (-2.8A)
None
None
 0.86A 3w9tF-4xvhA:
undetectable		 3w9tF-4xvhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.89A 4ctjC-5xg9B:
undetectable		 4ctjC-5xg9B:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.87A 5ec8C-5xg9B:
undetectable		 5ec8C-5xg9B:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.86A 5njvD-5xg9B:
undetectable		 5njvD-5xg9B:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.97A 5wz1G-5xg9B:
undetectable		 5wz1G-5xg9B:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.95A 5wz1H-5xg9B:
undetectable		 5wz1H-5xg9B:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)
(Chaetomium) 		5 / 12 HIS A 335
THR A 334
GLY A 325
HIS A 329
MET A 281
 None
None
None
PEU  A 402 ( 4.9A)
None
 1.32A 6exiD-4xvhA:
2.1		 6exiD-4xvhA:
15.17