SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PEF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 6 PHE B 173
ALA B 202
TYR B 105
ILE B 167
 None
None
PEF  B 301 (-4.0A)
None
 1.23A 1oniH-5uwbB:
undetectable
1oniI-5uwbB:
undetectable		 1oniH-5uwbB:
21.82
1oniI-5uwbB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2qgu PROBABLE SIGNAL
PEPTIDE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 VAL A  64
ILE A 168
ILE A 166
VAL A 148
LEU A 113
 PEF  A 301 ( 4.8A)
PEF  A 301 (-4.3A)
PEF  A 301 ( 4.0A)
None
None
 1.08A 2ft9A-2qguA:
undetectable		 2ft9A-2qguA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1
(Mus
musculus) 		5 / 12 ALA A 270
ASP A 271
LEU A 307
ARG A 314
LEU A 438
 PEF  A 201 ( 4.4A)
None
PEF  A 201 (-4.0A)
None
None
 0.98A 2jfaB-1yp0A:
21.5		 2jfaB-1yp0A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1
(Mus
musculus) 		4 / 7 ILE A 245
ARG A 314
LEU A 307
ASP A 310
 None
None
PEF  A 201 (-4.0A)
None
 1.04A 2qqcB-1yp0A:
undetectable
2qqcC-1yp0A:
undetectable		 2qqcB-1yp0A:
23.71
2qqcC-1yp0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1
(Mus
musculus) 		4 / 7 LEU A 307
ASP A 310
ILE A 245
ARG A 314
 PEF  A 201 (-4.0A)
None
None
None
 1.07A 2qqcI-1yp0A:
undetectable
2qqcL-1yp0A:
undetectable		 2qqcI-1yp0A:
11.06
2qqcL-1yp0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 7 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.97A 4a97E-5uwbB:
undetectable		 4a97E-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 8 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.94A 4a97C-5uwbB:
undetectable		 4a97C-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 8 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 1.00A 4a97D-5uwbB:
undetectable		 4a97D-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 8 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.95A 4a97G-5uwbB:
undetectable		 4a97G-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 7 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 0.95A 4a97H-5uwbB:
undetectable		 4a97H-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uwb TOLUENE TOLERANCE
PROTEIN
(Pseudomonas
putida) 		4 / 8 TYR B 144
VAL B 164
ILE B 167
ASN B 165
 PEF  B 302 (-4.0A)
PEF  B 302 ( 4.6A)
None
PEF  B 302 ( 4.1A)
 1.03A 4a97I-5uwbB:
undetectable		 4a97I-5uwbB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1
(Mus
musculus) 		5 / 12 LEU A 345
LEU A 438
ALA A 434
THR A 273
ALA A 270
 PEF  A 201 (-4.2A)
None
PEF  A 201 ( 3.8A)
None
PEF  A 201 ( 4.4A)
 1.09A 5mioB-1yp0A:
undetectable		 5mioB-1yp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4rhp UBIQUINONE
BIOSYNTHESIS PROTEIN
COQ9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 193
LEU A 204
THR A 254
ARG A 244
 None
None
None
PEF  A 401 (-3.9A)
 1.11A 6ew0F-4rhpA:
undetectable		 6ew0F-4rhpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1
(Mus
musculus) 		4 / 8 GLY A 342
HIS A 346
VAL A 349
ALA A 261
 PEF  A 201 (-3.5A)
None
PEF  A 201 ( 4.7A)
None
 0.76A 6hu9H-1yp0A:
undetectable
6hu9e-1yp0A:
undetectable		 6hu9H-1yp0A:
13.85
6hu9e-1yp0A:
20.75