SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PE8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 0.91A 1lweA-2yy7A:
undetectable		 1lweA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 1.02A 1s1xA-2yy7A:
undetectable		 1s1xA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 12 THR A 174
LEU A 173
LEU A 160
ILE A 118
ILE A  49
 AZM  A 302 (-3.3A)
AZM  A 302 (-3.7A)
None
PE8  A 303 (-4.9A)
None
 1.02A 3frqB-4x5sA:
undetectable		 3frqB-4x5sA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		11 / 12 ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.47A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		11 / 12 ASN A  62
HIS A  64
HIS A  89
HIS A  91
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.41A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		7 / 12 HIS A  64
HIS A  91
ILE A 118
VAL A 110
LEU A 173
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
PE8  A 303 (-4.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.28A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		12 / 12 ASN A  62
GLN A  87
HIS A  89
HIS A  91
HIS A 108
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.37A 3fw3B-4x5sA:
28.2		 3fw3B-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		7 / 12 GLN A  87
HIS A  89
HIS A  91
VAL A 110
ILE A 118
LEU A 173
THR A 175
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.41A 3fw3B-4x5sA:
28.2		 3fw3B-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		6 / 12 HIS A  89
HIS A  91
VAL A 120
ILE A 118
LEU A 173
THR A 175
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.32A 3fw3B-4x5sA:
28.2		 3fw3B-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		6 / 12 HIS A  91
ILE A 118
VAL A 110
LEU A 173
THR A 174
THR A 175
 ZN  A 301 ( 3.2A)
PE8  A 303 (-4.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.27A 3fw3B-4x5sA:
28.2		 3fw3B-4x5sA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 9 VAL A 163
TYR A 156
TYR A 157
GLY A 162
TRP A 153
 None
None
None
None
PE8  A2002 (-4.8A)
 1.45A 3hvtA-2yy7A:
0.9		 3hvtA-2yy7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3l9v PUTATIVE
THIOL-DISULFIDE
ISOMERASE OR
THIOREDOXIN
(Salmonella
enterica) 		4 / 8 ASP A  40
PRO A  28
PRO A 148
GLU A  21
 None
PE8  A   1 (-4.2A)
None
None
 0.99A 3oyaA-3l9vA:
undetectable		 3oyaA-3l9vA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 11 HIS A  89
LYS A 112
VAL A 110
LEU A 173
THR A 174
 ZN  A 301 ( 3.1A)
PE8  A 303 (-2.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.17A 4ygfB-4x5sA:
30.3		 4ygfB-4x5sA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 12 GLU A  95
LYS A 112
VAL A 110
LEU A 173
THR A 174
 AZM  A 302 ( 4.5A)
PE8  A 303 (-2.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.42A 4ygfE-4x5sA:
30.8		 4ygfE-4x5sA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 12 HIS A  89
LYS A 112
VAL A 110
LEU A 173
THR A 174
 ZN  A 301 ( 3.1A)
PE8  A 303 (-2.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.21A 4ygfE-4x5sA:
30.8		 4ygfE-4x5sA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 12 HIS A  89
LYS A 112
VAL A 110
LEU A 173
THR A 174
 ZN  A 301 ( 3.1A)
PE8  A 303 (-2.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.23A 4ygfG-4x5sA:
7.6		 4ygfG-4x5sA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		5 / 12 LYS A 112
VAL A 120
LEU A 173
THR A 174
TRP A 184
 PE8  A 303 (-2.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.77A 4ygfG-4x5sA:
7.6		 4ygfG-4x5sA:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(Sulfurihydrogeni
bium
azorense) 		6 / 12 VAL A 110
LYS A 112
VAL A 120
LEU A 173
THR A 174
TRP A 184
 AZM  A 302 (-4.8A)
PE8  A 303 (-2.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.58A 4yhaG-4x5sA:
30.2		 4yhaG-4x5sA:
37.55