SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PE5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
LEU A 388
 None
None
None
None
PE5  A 407 (-3.6A)
 1.13A 1bsxA-2r09A:
undetectable		 1bsxA-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
LEU A 388
 None
None
None
None
PE5  A 407 (-3.6A)
 1.13A 1bsxB-2r09A:
undetectable		 1bsxB-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.79A 1gtnD-4ud8A:
undetectable
1gtnE-4ud8A:
undetectable		 1gtnD-4ud8A:
10.22
1gtnE-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.86A 1gtnF-4ud8A:
undetectable
1gtnG-4ud8A:
undetectable		 1gtnF-4ud8A:
10.22
1gtnG-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.88A 1gtnJ-4ud8A:
undetectable
1gtnK-4ud8A:
undetectable		 1gtnJ-4ud8A:
10.22
1gtnK-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 8 GLY A 166
SER A 163
TYR A 131
HIS A 129
 PE5  A 558 ( 3.7A)
None
None
None
 1.06A 1maaD-2yeqA:
undetectable		 1maaD-2yeqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 7 ARG A 359
ASN A 430
HIS A 432
TYR A 347
 PE5  A 531 (-3.8A)
None
EDO  A 579 (-4.0A)
PE5  A 531 (-3.6A)
 1.43A 1tdnA-2yeqA:
undetectable		 1tdnA-2yeqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 GLY A  16
LEU A  25
GLY A 102
ALA A 200
ALA A 197
 None
None
PE5  A 530 ( 4.7A)
PE5  A 530 ( 3.9A)
PE5  A 530 (-4.1A)
 0.98A 2bm9F-2yeqA:
undetectable		 2bm9F-2yeqA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 10 ILE A 225
PHE A 218
LEU A 145
VAL A 146
LEU A 239
 PE5  A 407 ( 4.4A)
None
None
None
None
 1.35A 2w98A-2r09A:
undetectable		 2w98A-2r09A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		4 / 4 VAL A 462
TYR A 131
VAL A 168
SER A 163
 None
None
PE5  A 558 ( 4.8A)
None
 1.40A 2x45B-2yeqA:
0.0		 2x45B-2yeqA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2oa5 HYPOTHETICAL PROTEIN
BQLF2
(Murid
gammaherpesvirus
4) 		4 / 8 LEU A  20
LYS A  21
ASN A  24
LEU A  27
 None
PE5  A4870 (-3.2A)
None
None
 0.59A 2xn3A-2oa5A:
undetectable
2xn3B-2oa5A:
undetectable		 2xn3A-2oa5A:
15.22
2xn3B-2oa5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.23A 2zj0B-5xjgA:
undetectable		 2zj0B-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.22A 2zj0C-5xjgA:
undetectable		 2zj0C-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3ce6B-5xjgA:
undetectable		 3ce6B-5xjgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3ce6D-5xjgA:
undetectable		 3ce6D-5xjgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vibrio
parahaemolyticus
;
synthetic
construct) 		4 / 4 LYS A  41
SER A 215
LEU A 234
SER A 218
 PE5  A 301 (-2.5A)
None
PE5  A 301 (-4.1A)
CRO  A  66 ( 3.2A)
 1.45A 3ik6H-4xgyA:
0.0		 3ik6H-4xgyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vibrio
parahaemolyticus
;
synthetic
construct) 		4 / 5 LYS A  41
SER A 215
LEU A 234
SER A 218
 PE5  A 301 (-2.5A)
None
PE5  A 301 (-4.1A)
CRO  A  66 ( 3.2A)
 1.48A 3iluH-4xgyA:
undetectable		 3iluH-4xgyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3n58C-5xjgA:
undetectable		 3n58C-5xjgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 VAL A 279
VAL A 311
TYR A 233
ILE A 235
GLN A 232
 None
None
None
PE5  A1216 (-3.9A)
None
 1.25A 3retA-5ee7A:
1.5
3retB-5ee7A:
1.5		 3retA-5ee7A:
12.90
3retB-5ee7A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Bacteroides
fragilis) 		5 / 12 ILE A  50
GLU A  11
GLU A  75
TYR A  46
HIS A   9
 None
None
PE5  A1002 (-3.7A)
None
None
 1.32A 4a97B-4r37A:
undetectable
4a97C-4r37A:
undetectable		 4a97B-4r37A:
20.99
4a97C-4r37A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 LEU A  75
PHE A 377
ASP A 116
TYR A  74
 None
PE5  A 901 (-3.9A)
FAD  A 601 (-4.1A)
None
 0.92A 4drjB-4ud8A:
undetectable		 4drjB-4ud8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1y89 DEVB PROTEIN
(Vibrio
cholerae) 		4 / 8 ASP A  19
ASP A  20
PHE A   7
LYS A   5
 None
PE5  A 242 (-3.6A)
None
None
 0.97A 4f8hA-1y89A:
undetectable
4f8hB-1y89A:
undetectable		 4f8hA-1y89A:
20.32
4f8hB-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1y89 DEVB PROTEIN
(Vibrio
cholerae) 		4 / 8 ASP A  19
ASP A  20
PHE A   7
LYS A   5
 None
PE5  A 242 (-3.6A)
None
None
 1.00A 4f8hB-1y89A:
undetectable
4f8hC-1y89A:
undetectable		 4f8hB-1y89A:
20.32
4f8hC-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1y89 DEVB PROTEIN
(Vibrio
cholerae) 		4 / 8 ASP A  19
ASP A  20
PHE A   7
LYS A   5
 None
PE5  A 242 (-3.6A)
None
None
 0.97A 4f8hC-1y89A:
undetectable
4f8hD-1y89A:
undetectable		 4f8hC-1y89A:
20.32
4f8hD-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1y89 DEVB PROTEIN
(Vibrio
cholerae) 		4 / 8 ASP A  19
ASP A  20
PHE A   7
LYS A   5
 None
PE5  A 242 (-3.6A)
None
None
 0.97A 4f8hD-1y89A:
undetectable
4f8hE-1y89A:
undetectable		 4f8hD-1y89A:
20.32
4f8hE-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1y89 DEVB PROTEIN
(Vibrio
cholerae) 		4 / 8 PHE A   7
LYS A   5
ASP A  19
ASP A  20
 None
None
None
PE5  A 242 (-3.6A)
 0.98A 4f8hA-1y89A:
undetectable
4f8hE-1y89A:
undetectable		 4f8hA-1y89A:
20.32
4f8hE-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		3 / 3 ASP A  48
ARG A  46
ASP A  69
 PE5  A 202 ( 4.0A)
PE5  A 202 (-4.0A)
PE5  A 202 (-3.9A)
 0.88A 4fzvA-4n27A:
undetectable		 4fzvA-4n27A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		3 / 3 LYS A  68
PRO A  69
SER A  70
 PE5  A 580 ( 2.9A)
None
PE5  A 580 ( 3.8A)
 0.48A 4k50I-2yeqA:
undetectable		 4k50I-2yeqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
 None
PE5  A1216 (-4.7A)
None
None
None
 1.37A 4mmfA-5ee7A:
undetectable		 4mmfA-5ee7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
 None
PE5  A1216 (-4.7A)
None
None
None
 1.40A 4mmfB-5ee7A:
undetectable		 4mmfB-5ee7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2r09 CYTOHESIN-3
(Mus
musculus) 		3 / 3 MET A 199
MET A 169
TYR A 385
 PE5  A 407 ( 3.9A)
None
PE5  A 407 (-3.7A)
 1.17A 4p6xI-2r09A:
undetectable		 4p6xI-2r09A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		5 / 12 ASP A  15
ALA A  14
GLN A  61
GLY A  38
SER A  18
 None
None
PE5  A 203 (-3.0A)
None
None
 1.36A 5hfjC-4n27A:
undetectable		 5hfjC-4n27A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 SER A 254
VAL A 257
GLY A 292
ALA A 291
 None
None
PE5  A 601 (-3.9A)
None
 0.99A 5k50A-5xjgA:
undetectable		 5k50A-5xjgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 225
ILE A 219
LEU A 193
LEU A 235
LEU A 239
 PE5  A 407 ( 4.4A)
None
None
None
None
 1.20A 5tiwA-2r09A:
undetectable		 5tiwA-2r09A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2yeq ALKALINE PHOSPHATASE
D
(Bacillus
subtilis) 		5 / 12 GLY A 166
VAL A 462
ASN A 415
GLN A 126
GLY A 413
 PE5  A 558 ( 3.7A)
None
EDO  A 533 ( 4.7A)
None
EDO  A 552 ( 3.8A)
 1.19A 6gneA-2yeqA:
undetectable		 6gneA-2yeqA:
24.01