SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PDS'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 6 LEU A 348
LYS A 371
VAL A 393
ARG A 465
PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
0.87A 1opjB-2i0eA:
12.9
1opjB-2i0eA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
3 / 3 LYS A 371
ASP A 466
CYH A 502
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 3.9A)
1.46A 2br4F-2i0eA:
undetectable
2br4F-2i0eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
9 / 12 LEU A 348
VAL A 356
ALA A 369
VAL A 423
ASP A 466
LYS A 468
ASN A 471
MET A 473
ASP A 484
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.3A)
None
None
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
PDS  A 901 (-3.6A)
0.67A 2fumA-2i0eA:
25.9
2fumA-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
10 / 12 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
LYS A 468
ASN A 471
MET A 473
ASP A 484
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
None
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
PDS  A 901 (-3.6A)
0.80A 2fumB-2i0eA:
25.8
2fumB-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 12 LEU A 348
GLY A 349
VAL A 356
ALA A 369
TYR A 422
VAL A 423
PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
0.72A 2fumC-2i0eA:
24.1
2fumC-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
7 / 12 LEU A 348
VAL A 356
ALA A 369
TYR A 422
VAL A 423
ASN A 471
MET A 473
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
0.68A 2fumC-2i0eA:
24.1
2fumC-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
7 / 12 LEU A 348
VAL A 356
ALA A 369
MET A 420
LYS A 468
ASN A 471
MET A 473
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.8A)
None
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
0.83A 2fumD-2i0eA:
24.2
2fumD-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 6 LEU A 348
LYS A 371
VAL A 393
ARG A 465
PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
0.84A 2hyyA-2i0eA:
13.2
2hyyA-2i0eA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
7 / 12 LEU A 348
GLY A 349
VAL A 356
ALA A 369
LYS A 371
TYR A 422
ALA A 483
PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
0.65A 3lxkA-2i0eA:
23.3
3lxkA-2i0eA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
7 / 12 VAL A 356
ALA A 369
LYS A 371
GLU A 390
VAL A 393
TYR A 422
ALA A 483
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
None
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
0.91A 3oezB-2i0eA:
13.2
3oezB-2i0eA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
5 / 12 GLY A 349
VAL A 356
ALA A 369
LYS A 371
LEU A 394
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
0.42A 3ohtB-2i0eA:
4.8
3ohtB-2i0eA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 10 LEU A 348
GLY A 349
GLY A 351
VAL A 356
ALA A 369
TYR A 422
PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
None
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
0.59A 4ckjA-2i0eA:
18.5
4ckjA-2i0eA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
8 / 12 PHE A 353
VAL A 356
ALA A 369
ASP A 427
ASP A 466
LYS A 468
ASN A 471
ASP A 484
PDS  A 901 (-4.3A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
None
None
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
0.76A 4i41A-2i0eA:
28.2
4i41A-2i0eA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 7 VAL A 356
ALA A 369
LEU A 373
MET A 420
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
PDS  A 901 ( 4.8A)
0.58A 4l9iA-2i0eA:
13.3
4l9iA-2i0eA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
5 / 8 GLY A 351
VAL A 356
ALA A 369
LYS A 371
MET A 420
None
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
PDS  A 901 ( 4.8A)
0.72A 4l9iB-2i0eA:
25.2
4l9iB-2i0eA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
8 / 12 ALA A 369
LYS A 371
GLU A 390
THR A 404
MET A 420
TYR A 422
ALA A 483
ASP A 484
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
PDS  A 901 (-3.2A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
PDS  A 901 (-3.6A)
0.63A 4qmnA-2i0eA:
28.5
4qmnA-2i0eA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 12 GLY A 349
VAL A 356
ALA A 369
THR A 404
MET A 420
TYR A 422
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-3.2A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
0.54A 4qmzA-2i0eA:
28.4
4qmzA-2i0eA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 6 LEU A 348
VAL A 356
LYS A 371
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
0.28A 4tyjA-2i0eA:
15.1
4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 6 LEU A 348
VAL A 356
LYS A 371
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
0.70A 4tyjA-2i0eA:
15.1
4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 6 VAL A 356
LYS A 371
ARG A 465
ILE A 482
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
0.68A 4tyjA-2i0eA:
15.1
4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 10 LEU A 348
VAL A 356
GLU A 390
TYR A 422
ARG A 465
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
None
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
0.82A 4u0iA-2i0eA:
20.2
4u0iA-2i0eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
8 / 11 LEU A 348
GLY A 351
VAL A 356
ALA A 369
TYR A 422
ASN A 471
ALA A 483
ASP A 484
PDS  A 901 (-3.9A)
None
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
PDS  A 901 (-3.4A)
PDS  A 901 (-3.6A)
0.70A 4u5jA-2i0eA:
14.5
4u5jA-2i0eA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 7 VAL A 356
LYS A 371
ARG A 465
ILE A 482
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
0.88A 4uxqA-2i0eA:
14.5
4uxqA-2i0eA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 9 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
0.72A 4v01A-2i0eA:
13.1
4v01A-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 9 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
0.90A 4v01B-2i0eA:
13.2
4v01B-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 10 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
0.95A 4v04B-2i0eA:
14.3
4v04B-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 7 GLY A 351
LEU A 406
ASP A 484
PHE A 485
None
None
PDS  A 901 (-3.6A)
None
0.80A 5hieB-2i0eA:
10.8
5hieB-2i0eA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
4 / 7 GLY A 349
GLY A 351
LYS A 371
LEU A 373
PDS  A 901 ( 3.7A)
None
PDS  A 901 ( 4.5A)
None
0.87A 5izfA-2i0eA:
37.2
5izfA-2i0eA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
5 / 7 GLY A 349
GLY A 351
SER A 352
GLY A 354
LEU A 373
PDS  A 901 ( 3.7A)
None
None
None
None
1.32A 5izjB-2i0eA:
37.2
5izjB-2i0eA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
5 / 7 GLY A 349
GLY A 351
VAL A 356
LYS A 371
LEU A 373
PDS  A 901 ( 3.7A)
None
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
0.75A 5izjA-2i0eA:
25.5
5izjA-2i0eA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 10 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
0.54A 5n3hA-2i0eA:
37.5
5n3hA-2i0eA:
36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2i0e PROTEIN KINASE
C-BETA II

(Homo
sapiens)
6 / 12 LEU A 348
VAL A 356
ALA A 369
GLU A 390
TYR A 422
ALA A 483
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
0.70A 5zv2A-2i0eA:
9.0
5zv2A-2i0eA:
14.83