SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PDS'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1OPJ_B_STIB4_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 6 | LEU A 348LYS A 371VAL A 393ARG A 465 | PDS A 901 (-3.9A)PDS A 901 ( 4.5A)NoneTPO A 500 ( 2.9A) | 0.87A | 1opjB-2i0eA:12.9 | 1opjB-2i0eA:27.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BR4_F_SAMF301_1 (CEPHALOSPORINHYDROXYLASE CMCI) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 3 / 3 | LYS A 371ASP A 466CYH A 502 | PDS A 901 ( 4.5A)NoneTPO A 500 ( 3.9A) | 1.46A | 2br4F-2i0eA:undetectable | 2br4F-2i0eA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_A_MIXA539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 9 / 12 | LEU A 348VAL A 356ALA A 369VAL A 423ASP A 466LYS A 468ASN A 471MET A 473ASP A 484 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.3A)NoneNonePDS A 901 (-4.3A)PDS A 901 (-3.6A)PDS A 901 (-3.6A) | 0.67A | 2fumA-2i0eA:25.9 | 2fumA-2i0eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_B_MIXB1539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 10 / 12 | LEU A 348VAL A 356ALA A 369MET A 420TYR A 422VAL A 423LYS A 468ASN A 471MET A 473ASP A 484 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.8A)PDS A 901 (-4.7A)PDS A 901 (-4.3A)NonePDS A 901 (-4.3A)PDS A 901 (-3.6A)PDS A 901 (-3.6A) | 0.80A | 2fumB-2i0eA:25.8 | 2fumB-2i0eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_C_MIXC2539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 12 | LEU A 348GLY A 349VAL A 356ALA A 369TYR A 422VAL A 423 | PDS A 901 (-3.9A)PDS A 901 ( 3.7A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.7A)PDS A 901 (-4.3A) | 0.72A | 2fumC-2i0eA:24.1 | 2fumC-2i0eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_C_MIXC2539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 7 / 12 | LEU A 348VAL A 356ALA A 369TYR A 422VAL A 423ASN A 471MET A 473 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.7A)PDS A 901 (-4.3A)PDS A 901 (-4.3A)PDS A 901 (-3.6A) | 0.68A | 2fumC-2i0eA:24.1 | 2fumC-2i0eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_D_MIXD3539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 7 / 12 | LEU A 348VAL A 356ALA A 369MET A 420LYS A 468ASN A 471MET A 473 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.8A)NonePDS A 901 (-4.3A)PDS A 901 (-3.6A) | 0.83A | 2fumD-2i0eA:24.2 | 2fumD-2i0eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HYY_A_STIA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 6 | LEU A 348LYS A 371VAL A 393ARG A 465 | PDS A 901 (-3.9A)PDS A 901 ( 4.5A)NoneTPO A 500 ( 2.9A) | 0.84A | 2hyyA-2i0eA:13.2 | 2hyyA-2i0eA:26.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LXK_A_MI1A1125_1 (TYROSINE-PROTEINKINASE JAK3) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 7 / 12 | LEU A 348GLY A 349VAL A 356ALA A 369LYS A 371TYR A 422ALA A 483 | PDS A 901 (-3.9A)PDS A 901 ( 3.7A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.5A)PDS A 901 (-4.7A)PDS A 901 (-3.4A) | 0.65A | 3lxkA-2i0eA:23.3 | 3lxkA-2i0eA:25.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OEZ_B_STIB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 7 / 12 | VAL A 356ALA A 369LYS A 371GLU A 390VAL A 393TYR A 422ALA A 483 | PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.5A)NoneNonePDS A 901 (-4.7A)PDS A 901 (-3.4A) | 0.91A | 3oezB-2i0eA:13.2 | 3oezB-2i0eA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_B_1N1B1000_1 (P38A) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 5 / 12 | GLY A 349VAL A 356ALA A 369LYS A 371LEU A 394 | PDS A 901 ( 3.7A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.5A)None | 0.42A | 3ohtB-2i0eA:4.8 | 3ohtB-2i0eA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CKJ_A_ADNA2014_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 10 | LEU A 348GLY A 349GLY A 351VAL A 356ALA A 369TYR A 422 | PDS A 901 (-3.9A)PDS A 901 ( 3.7A)NonePDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.7A) | 0.59A | 4ckjA-2i0eA:18.5 | 4ckjA-2i0eA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4I41_A_MIXA500_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 8 / 12 | PHE A 353VAL A 356ALA A 369ASP A 427ASP A 466LYS A 468ASN A 471ASP A 484 | PDS A 901 (-4.3A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)NoneNoneNonePDS A 901 (-4.3A)PDS A 901 (-3.6A) | 0.76A | 4i41A-2i0eA:28.2 | 4i41A-2i0eA:25.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_A_8PRA601_1 (RHODOPSIN KINASE) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 7 | VAL A 356ALA A 369LEU A 373MET A 420 | PDS A 901 (-4.2A)PDS A 901 (-3.3A)NonePDS A 901 ( 4.8A) | 0.58A | 4l9iA-2i0eA:13.3 | 4l9iA-2i0eA:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_B_8PRB601_1 (RHODOPSIN KINASE) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 5 / 8 | GLY A 351VAL A 356ALA A 369LYS A 371MET A 420 | NonePDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.5A)PDS A 901 ( 4.8A) | 0.72A | 4l9iB-2i0eA:25.2 | 4l9iB-2i0eA:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QMN_A_DB8A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 8 / 12 | ALA A 369LYS A 371GLU A 390THR A 404MET A 420TYR A 422ALA A 483ASP A 484 | PDS A 901 (-3.3A)PDS A 901 ( 4.5A)NonePDS A 901 (-3.2A)PDS A 901 ( 4.8A)PDS A 901 (-4.7A)PDS A 901 (-3.4A)PDS A 901 (-3.6A) | 0.63A | 4qmnA-2i0eA:28.5 | 4qmnA-2i0eA:27.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QMZ_A_B49A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 12 | GLY A 349VAL A 356ALA A 369THR A 404MET A 420TYR A 422 | PDS A 901 ( 3.7A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-3.2A)PDS A 901 ( 4.8A)PDS A 901 (-4.7A) | 0.54A | 4qmzA-2i0eA:28.4 | 4qmzA-2i0eA:27.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 6 | LEU A 348VAL A 356LYS A 371ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 ( 4.5A)None | 0.28A | 4tyjA-2i0eA:15.1 | 4tyjA-2i0eA:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 6 | LEU A 348VAL A 356LYS A 371ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 ( 4.5A)None | 0.70A | 4tyjA-2i0eA:15.1 | 4tyjA-2i0eA:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 6 | VAL A 356LYS A 371ARG A 465ILE A 482 | PDS A 901 (-4.2A)PDS A 901 ( 4.5A)TPO A 500 ( 2.9A)None | 0.68A | 4tyjA-2i0eA:15.1 | 4tyjA-2i0eA:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4U0I_A_0LIA1001_1 (MAST/STEM CELLGROWTH FACTORRECEPTORKIT,MAST/STEM CELLGROWTH FACTORRECEPTOR KIT) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 10 | LEU A 348VAL A 356GLU A 390TYR A 422ARG A 465ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)NonePDS A 901 (-4.7A)TPO A 500 ( 2.9A)None | 0.82A | 4u0iA-2i0eA:20.2 | 4u0iA-2i0eA:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4U5J_A_RXTA601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 8 / 11 | LEU A 348GLY A 351VAL A 356ALA A 369TYR A 422ASN A 471ALA A 483ASP A 484 | PDS A 901 (-3.9A)NonePDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.7A)PDS A 901 (-4.3A)PDS A 901 (-3.4A)PDS A 901 (-3.6A) | 0.70A | 4u5jA-2i0eA:14.5 | 4u5jA-2i0eA:25.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 7 | VAL A 356LYS A 371ARG A 465ILE A 482 | PDS A 901 (-4.2A)PDS A 901 ( 4.5A)TPO A 500 ( 2.9A)None | 0.88A | 4uxqA-2i0eA:14.5 | 4uxqA-2i0eA:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V01_A_0LIA1776_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 9 | LEU A 348VAL A 356LYS A 371TYR A 422ARG A 465ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 ( 4.5A)PDS A 901 (-4.7A)TPO A 500 ( 2.9A)None | 0.72A | 4v01A-2i0eA:13.1 | 4v01A-2i0eA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V01_B_0LIB1770_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 9 | LEU A 348VAL A 356LYS A 371TYR A 422ARG A 465ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 ( 4.5A)PDS A 901 (-4.7A)TPO A 500 ( 2.9A)None | 0.90A | 4v01B-2i0eA:13.2 | 4v01B-2i0eA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 10 | LEU A 348VAL A 356LYS A 371TYR A 422ARG A 465ILE A 482 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 ( 4.5A)PDS A 901 (-4.7A)TPO A 500 ( 2.9A)None | 0.95A | 4v04B-2i0eA:14.3 | 4v04B-2i0eA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_B_P06B801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 7 | GLY A 351LEU A 406ASP A 484PHE A 485 | NoneNonePDS A 901 (-3.6A)None | 0.80A | 5hieB-2i0eA:10.8 | 5hieB-2i0eA:25.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5IZF_E_AZ1E2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA6J9-ZEU-DAR-ACA-DAR-NH2) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 4 / 7 | GLY A 349GLY A 351LYS A 371LEU A 373 | PDS A 901 ( 3.7A)NonePDS A 901 ( 4.5A)None | 0.87A | 5izfA-2i0eA:37.2 | 5izfA-2i0eA:36.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5IZJ_F_AZ1F2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR-DAR) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 5 / 7 | GLY A 349GLY A 351SER A 352GLY A 354LEU A 373 | PDS A 901 ( 3.7A)NoneNoneNoneNone | 1.32A | 5izjB-2i0eA:37.2 | 5izjB-2i0eA:36.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5IZJ_G_AZ1G2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 5 / 7 | GLY A 349GLY A 351VAL A 356LYS A 371LEU A 373 | PDS A 901 ( 3.7A)NonePDS A 901 (-4.2A)PDS A 901 ( 4.5A)None | 0.75A | 5izjA-2i0eA:25.5 | 5izjA-2i0eA:36.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5N3H_A_NCAA401_0 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 10 | LEU A 348VAL A 356ALA A 369MET A 420TYR A 422VAL A 423 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 ( 4.8A)PDS A 901 (-4.7A)PDS A 901 (-4.3A) | 0.54A | 5n3hA-2i0eA:37.5 | 5n3hA-2i0eA:36.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZV2_A_LEVA801_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1) |
2i0e | PROTEIN KINASEC-BETA II (Homosapiens) | 6 / 12 | LEU A 348VAL A 356ALA A 369GLU A 390TYR A 422ALA A 483 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)NonePDS A 901 (-4.7A)PDS A 901 (-3.4A) | 0.70A | 5zv2A-2i0eA:9.0 | 5zv2A-2i0eA:14.83 |