SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PD8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 158
ALA A 155
ARG A  92
LEU A  42
ILE A 112
 None
PD8  A1421 (-3.9A)
PD8  A1421 ( 4.9A)
None
None
 1.29A 1y0xX-1w78A:
undetectable		 1y0xX-1w78A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  32
GLY A 190
GLY A 151
LEU A 149
GLY A 148
 None
KCX  A 188 ( 4.1A)
KCX  A 188 ( 4.1A)
PD8  A1421 ( 4.4A)
PD8  A1421 (-4.0A)
 0.93A 1y4lA-1w78A:
undetectable		 1y4lA-1w78A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 TYR A  81
SER A 130
LEU A 134
ILE A 158
ALA A 155
 None
None
None
None
PD8  A1421 (-3.9A)
 1.46A 2a58A-1w78A:
3.7
2a58E-1w78A:
3.7		 2a58A-1w78A:
17.49
2a58E-1w78A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 ILE A 158
ALA A 155
TYR A  81
SER A 130
LEU A 134
 None
PD8  A1421 (-3.9A)
None
None
None
 1.46A 2a58C-1w78A:
3.4
2a58D-1w78A:
3.8		 2a58C-1w78A:
17.49
2a58D-1w78A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		4 / 4 LEU A  30
SER A 183
ASP A 175
ASP A 335
 PD8  A1421 ( 4.7A)
None
None
None
 1.26A 2br4B-1w78A:
undetectable		 2br4B-1w78A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		4 / 8 PRO A  84
VAL A 303
SER A 403
ALA A 408
 PD8  A1421 (-4.5A)
ADP  A1425 (-4.2A)
None
None
 1.01A 2v32A-1w78A:
undetectable
2v32B-1w78A:
undetectable		 2v32A-1w78A:
20.95
2v32B-1w78A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 TYR A  89
LEU A 145
SER A  83
VAL A 159
LEU A  32
 None
None
PD8  A1421 ( 3.7A)
None
None
 1.33A 3m7rA-1w78A:
undetectable		 3m7rA-1w78A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1w78 FOLC BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		3 / 3 GLY A 150
LEU A 149
HIS A 173
 KCX  A 188 ( 3.4A)
PD8  A1421 ( 4.4A)
MG  A1422 ( 3.4A)
 0.67A 5u63A-1w78A:
2.3		 5u63A-1w78A:
24.26