SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PD2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 HIS A 143
ASP A 145
THR A 164
HIS A 227
SER A 239
 ZN  A1252 ( 3.3A)
ZN  A1252 ( 2.4A)
None
ZN  A1252 ( 3.3A)
PD2  A1254 (-3.3A)
 0.60A 1uofA-2jigA:
8.3		 1uofA-2jigA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A 155
ASP A 157
HIS A 218
VAL A 220
SER A 232
 MN  A 601 (-3.5A)
MN  A 601 ( 2.5A)
MN  A 601 ( 3.4A)
PD2  A 603 (-4.9A)
PD2  A 603 (-3.1A)
 0.65A 1uofA-4nhyA:
9.3		 1uofA-4nhyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 11 HIS A 204
ASP A 206
HIS A 266
ARG A 277
SER A 219
 MN  A 302 ( 3.6A)
MN  A 302 ( 2.7A)
MN  A 302 ( 3.3A)
PD2  A 301 (-2.7A)
PD2  A 301 ( 4.5A)
 1.46A 1uofA-4nrqA:
8.1		 1uofA-4nrqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 168
ILE A 233
ILE A 167
LEU A 231
LEU A  76
 None
None
PD2  A 603 ( 4.2A)
None
None
 0.99A 1xdkF-4nhyA:
undetectable		 1xdkF-4nhyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 104
ILE A 233
LEU A 170
SER A 232
 None
None
None
PD2  A 603 (-3.1A)
 0.99A 2byoA-4nhyA:
undetectable		 2byoA-4nhyA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		3 / 3 LYS A 242
ILE A 270
PHE A 268
 PD2  A 401 (-2.9A)
None
None
 0.90A 3j7zS-4lxlA:
undetectable
3j7za-4lxlA:
undetectable		 3j7zS-4lxlA:
15.30
3j7za-4lxlA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 ASN A 199
SER A 289
GLU A 191
VAL A 161
GLU A 162
 PD2  A 401 ( 4.5A)
None
NI  A 402 ( 2.6A)
None
None
 1.48A 3jayA-4lxlA:
undetectable		 3jayA-4lxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 ASN A 199
SER A 289
GLU A 191
VAL A 161
GLU A 162
 PD2  A 401 ( 4.5A)
None
NI  A 402 ( 2.6A)
None
None
 1.37A 3jb2A-4lxlA:
undetectable		 3jb2A-4lxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 LEU A 132
HIS A 143
ASP A 145
HIS A 227
TRP A 243
 None
ZN  A1252 ( 3.3A)
ZN  A1252 ( 2.4A)
ZN  A1252 ( 3.3A)
PD2  A1254 (-4.1A)
 0.95A 3kcxA-2jigA:
8.3		 3kcxA-2jigA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 TYR A 134
LEU A 132
HIS A 143
HIS A 227
TRP A 243
 PD2  A1254 (-4.5A)
None
ZN  A1252 ( 3.3A)
ZN  A1252 ( 3.3A)
PD2  A1254 (-4.1A)
 1.32A 3kcxA-2jigA:
8.3		 3kcxA-2jigA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 4 SER A  90
GLY A 228
GLU A 177
 None
PD2  A1254 (-3.8A)
None
 0.62A 3raeA-2jigA:
1.6
3raeC-2jigA:
undetectable		 3raeA-2jigA:
16.47
3raeC-2jigA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		4 / 7 ASN A 193
ASP A 206
ILE A 201
HIS A 266
 PD2  A 301 (-3.3A)
MN  A 302 ( 2.7A)
PD2  A 301 (-4.8A)
MN  A 302 ( 3.3A)
 1.06A 3t01A-4nrqA:
undetectable		 3t01A-4nrqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 115
ILE A 139
GLY A 235
ILE A 233
ILE A 167
LEU A 207
 None
None
None
None
PD2  A 603 ( 4.2A)
None
 1.16A 3uj6A-4nhyA:
undetectable		 3uj6A-4nhyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 TYR A 134
HIS A 143
HIS A 227
TYR A 168
 PD2  A1254 (-4.5A)
ZN  A1252 ( 3.3A)
ZN  A1252 ( 3.3A)
None
 1.37A 4df2A-2jigA:
undetectable		 4df2A-2jigA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 7 LYS A  55
LEU A  53
LEU A 210
SER A 239
 None
None
None
PD2  A1254 (-3.3A)
 1.16A 4iklA-2jigA:
undetectable
4iklB-2jigA:
undetectable		 4iklA-2jigA:
19.64
4iklB-2jigA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 4 SER A  90
GLY A 228
GLU A 177
 None
PD2  A1254 (-3.8A)
None
 0.58A 4juoA-2jigA:
undetectable
4juoC-2jigA:
undetectable		 4juoA-2jigA:
16.47
4juoC-2jigA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 139
GLY A 235
ILE A 233
ILE A 167
LEU A 207
 None
None
None
PD2  A 603 ( 4.2A)
None
 1.10A 4mwzA-4nhyA:
undetectable		 4mwzA-4nhyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 5 TYR A 134
ARG A  93
ASP A 149
GLU A 141
 PD2  A1254 (-4.5A)
GOL  A1255 (-4.3A)
None
None
 1.24A 4nkvB-2jigA:
undetectable		 4nkvB-2jigA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A 142
ARG A 230
SER A 232
PHE A  98
 None
PD2  A 603 (-2.6A)
PD2  A 603 (-3.1A)
None
 1.38A 4xzkA-4nhyA:
undetectable		 4xzkA-4nhyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		4 / 7 SER A 217
SER A 219
GLY A 251
ARG A 277
 PD2  A 301 ( 4.9A)
PD2  A 301 ( 4.5A)
None
PD2  A 301 (-2.7A)
 1.08A 6btxA-4nrqA:
undetectable		 6btxA-4nrqA:
19.52