SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PCP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 8 ALA A 295
GLY A 289
GLY A 135
ILE A 136
ALA A 150
 None
PCP  A 392 (-3.3A)
None
None
None
 1.32A 1sguA-2i14A:
undetectable		 1sguA-2i14A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		6 / 6 PHE A 134
ARG A 137
SER A 160
GLY A 174
THR A 175
ARG A 233
 PCP  A 392 (-4.2A)
PCP  A 392 (-2.8A)
None
None
None
PCP  A 392 (-4.0A)
 0.83A 2f7fA-2i14A:
36.0		 2f7fA-2i14A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 7 ALA A 144
GLY A 164
ASP A 148
VAL A 159
ARG A 137
 None
None
None
None
PCP  A 392 (-2.8A)
 1.38A 2uyqA-2i14A:
undetectable		 2uyqA-2i14A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 131
GLY A 135
GLY A 289
ILE A 122
ALA A 151
 None
None
PCP  A 392 (-3.3A)
None
None
 0.93A 2z0yB-2i14A:
undetectable		 2z0yB-2i14A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.96A 3g2oA-1p4aA:
2.4		 3g2oA-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.95A 3g2oB-1p4aA:
3.1		 3g2oB-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		6 / 9 GLY A 290
ALA A 291
ASP A 272
ILE A 276
GLY A 269
ILE A 122
 PCP  A 392 (-3.6A)
None
None
None
PCP  A 392 ( 4.1A)
None
 1.27A 3nu4B-2i14A:
undetectable		 3nu4B-2i14A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 10 LEU A 121
GLY A 230
ASP A 203
ASP A 204
VAL A  84
 None
None
PCP  A 604 (-2.6A)
PCP  A 604 (-2.8A)
None
 1.02A 3oxwA-1p4aA:
undetectable		 3oxwA-1p4aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 265
PHE A 266
PHE A 134
LEU A 234
VAL A 208
 None
None
PCP  A 392 (-4.2A)
None
None
 1.07A 4g1bD-2i14A:
undetectable		 4g1bD-2i14A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1p4a PUR OPERON REPRESSOR
(Bacillus
subtilis) 		5 / 12 GLY A 209
VAL A 238
ASN A 268
GLU A 234
ILE A 229
 PCP  A 604 (-3.4A)
None
None
None
None
 1.25A 4pd5A-1p4aA:
undetectable		 4pd5A-1p4aA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 289
GLY A 290
ILE A 292
GLY A 161
ILE A 147
 PCP  A 392 (-3.3A)
PCP  A 392 (-3.6A)
None
None
None
 1.09A 4qoiA-2i14A:
undetectable
4qoiB-2i14A:
undetectable		 4qoiA-2i14A:
20.65
4qoiB-2i14A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
 None
None
None
None
PCP  A 392 (-3.3A)
 1.21A 5i71A-2i14A:
undetectable		 5i71A-2i14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 136
GLY A 158
GLY A 164
LEU A 163
GLY A 289
 None
None
None
None
PCP  A 392 (-3.3A)
 1.17A 5i75A-2i14A:
undetectable		 5i75A-2i14A:
21.31