SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PCJ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRQ_A_STRA501_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	2z81	TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Mus musculus)	5 / 11	LEU A 367 VAL A 343 ILE A 341 LEU A 412 LEU A 389	None PCJ A 1 (-4.8A) PCJ A 1 ( 4.6A) None None	1.21A	1mrqA-2z81A: undetectable	1mrqA-2z81A: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD3_A_CHDA501_0 (FERROCHELATASE)	2z81	TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Mus musculus)	5 / 11	LEU A 362 LEU A 389 LEU A 412 ILE A 341 VAL A 351	None None None PCJ A 1 ( 4.6A) PCJ A 1 ( 4.0A)	1.06A	2qd3A-2z81A: undetectable	2qd3A-2z81A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVP_B_GBMB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	2z81	TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Mus musculus)	5 / 12	LEU A 367 VAL A 343 ILE A 341 LEU A 412 LEU A 389	None PCJ A 1 (-4.8A) PCJ A 1 ( 4.6A) None None	1.16A	4yvpB-2z81A: undetectable	4yvpB-2z81A: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_1 (CDL2.3B)	2z81	TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Mus musculus)	5 / 12	PHE A 256 LEU A 273 LEU A 270 PHE A 284 LEU A 335	None None None PCJ A 1 (-3.9A) None	1.12A	5iepA-2z81A: undetectable	5iepA-2z81A: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OG9_A_TESA503_1 (-)	2z81	TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Mus musculus)	5 / 9	LEU A 270 VAL A 331 LEU A 334 ILE A 314 LEU A 261	None None None None PCJ A 1 ( 4.5A)	1.26A	5og9A-2z81A: undetectable	5og9A-2z81A: 22.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MRQ_A_STRA501_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","2z81","TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B","Eptatretus burgeri;Mus musculus",5,"LEU A 367;VAL A 343;ILE A 341;LEU A 412;LEU A 389","None;PCJ A   1 (-4.8A);PCJ A   1 ( 4.6A);None;None","1.21A","1mrqA-2z81A:undetectable",null],["2QD3_A_CHDA501_0","FERROCHELATASE","2z81","TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B","Eptatretus burgeri;Mus musculus",5,"LEU A 362;LEU A 389;LEU A 412;ILE A 341;VAL A 351","None;None;None;PCJ A   1 ( 4.6A);PCJ A   1 ( 4.0A)","1.06A","2qd3A-2z81A:undetectable","1mrqA-2z81A:19.00"],["4YVP_B_GBMB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","2z81","TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B","Eptatretus burgeri;Mus musculus",5,"LEU A 367;VAL A 343;ILE A 341;LEU A 412;LEU A 389","None;PCJ A   1 (-4.8A);PCJ A   1 ( 4.6A);None;None","1.16A","4yvpB-2z81A:undetectable","2qd3A-2z81A:20.65"],["5IEP_A_VDYA201_1","CDL2.3B","2z81","TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B","Eptatretus burgeri;Mus musculus",5,"PHE A 256;LEU A 273;LEU A 270;PHE A 284;LEU A 335","None;None;None;PCJ A   1 (-3.9A);None","1.12A","5iepA-2z81A:undetectable","4yvpB-2z81A:19.00"],["5OG9_A_TESA503_1","-","2z81","TOLL-LIKE RECEPTOR 2, VARIABLE LYMPHOCYTE RECEPTOR B","Eptatretus burgeri;Mus musculus",5,"LEU A 270;VAL A 331;LEU A 334;ILE A 314;LEU A 261","None;None;None;None;PCJ A   1 ( 4.5A)","1.26A","5og9A-2z81A:undetectable","5iepA-2z81A:14.09"]]