SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PCD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		4 / 8 CYH A 138
CYH A 101
GLY B 265
GLN B 524
 FES  A1907 ( 2.3A)
FES  A1907 (-2.3A)
None
PCD  B1920 (-3.5A)
 0.87A 1ekjG-1ffvA:
undetectable
1ekjH-1ffvA:
undetectable		 1ekjG-1ffvA:
20.80
1ekjH-1ffvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 THR A 420
GLY A 422
HIS A 365
LEU A 432
VAL A 433
 PCD  A 921 (-4.2A)
PCD  A 921 (-3.4A)
None
None
None
 1.08A 1r30B-3fahA:
undetectable		 1r30B-3fahA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 ALA A 657
THR A 689
PRO A 690
PRO A 861
ALA A 864
 None
None
None
None
PCD  A 921 ( 3.7A)
 1.10A 1rv7A-3fahA:
undetectable
1rv7B-3fahA:
undetectable		 1rv7A-3fahA:
8.12
1rv7B-3fahA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 8 ASP A  19
ILE A 481
GLY A 243
GLY A 242
PRO A 239
 None
PCD  A1920 (-4.2A)
PCD  A1920 (-3.4A)
None
None
 1.16A 1sguA-1sb3A:
undetectable		 1sguA-1sb3A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 7 GLY A 696
GLY A 697
ASP A 630
SER A 695
 GOL  A 912 ( 3.1A)
GOL  A 912 ( 3.1A)
None
PCD  A 921 (-4.4A)
 0.83A 2oa1B-3fahA:
undetectable		 2oa1B-3fahA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		5 / 12 GLN B 692
ARG A 137
SER B 564
PRO B 759
GLY B 700
 PCD  B1920 (-3.4A)
None
PCD  B1920 (-4.0A)
None
None
 1.12A 2y6rC-1ffvB:
undetectable		 2y6rC-1ffvB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 GLY A 866
GLN A 655
THR A 704
ARG A 533
GLY A 697
 PCD  A 921 (-3.4A)
PCD  A 921 (-3.6A)
None
PCD  A 921 (-4.0A)
GOL  A 912 ( 3.1A)
 1.36A 2zxwA-3fahA:
undetectable
2zxwB-3fahA:
undetectable
2zxwT-3fahA:
undetectable		 2zxwA-3fahA:
21.15
2zxwB-3fahA:
13.55
2zxwT-3fahA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 ARG A 533
GLY A 697
GLY A 866
GLN A 655
THR A 704
 PCD  A 921 (-4.0A)
GOL  A 912 ( 3.1A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.6A)
None
 1.34A 2zxwG-3fahA:
undetectable
2zxwN-3fahA:
undetectable
2zxwO-3fahA:
undetectable		 2zxwG-3fahA:
7.02
2zxwN-3fahA:
21.15
2zxwO-3fahA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 ARG A 533
PHE A 421
GLY A 422
GLY A 697
GLN A 655
 PCD  A 921 (-4.0A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.4A)
GOL  A 912 ( 3.1A)
PCD  A 921 (-3.6A)
 1.06A 3ag3G-3fahA:
undetectable
3ag3N-3fahA:
undetectable
3ag3O-3fahA:
undetectable		 3ag3G-3fahA:
7.02
3ag3N-3fahA:
21.15
3ag3O-3fahA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 8 GLY B  33
CYH A  47
CYH A 136
PHE B 268
 None
FES  A1908 (-2.2A)
FES  A1907 (-2.3A)
PCD  B1920 (-3.6A)
 0.99A 3ko0D-1ffvB:
undetectable
3ko0E-1ffvB:
0.0		 3ko0D-1ffvB:
8.53
3ko0E-1ffvB:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 GLY A  26
CYH C  46
CYH C 135
PHE A 245
 None
FES  C1908 (-2.2A)
FES  C1907 (-2.3A)
PCD  A1920 (-3.4A)
 1.08A 3ko0D-1sb3A:
undetectable
3ko0E-1sb3A:
undetectable		 3ko0D-1sb3A:
7.84
3ko0E-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 GLY A 191
CYH A  45
CYH A 137
PHE A 421
 None
FES  A 909 (-2.3A)
FES  A 908 (-2.3A)
PCD  A 921 (-3.4A)
 1.08A 3ko0D-3fahA:
undetectable
3ko0E-3fahA:
undetectable		 3ko0D-3fahA:
7.39
3ko0E-3fahA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 8 GLY B  33
CYH A  47
CYH A 136
PHE B 268
 None
FES  A1908 (-2.2A)
FES  A1907 (-2.3A)
PCD  B1920 (-3.6A)
 1.00A 3ko0B-1ffvB:
0.4
3ko0J-1ffvB:
0.0		 3ko0B-1ffvB:
8.53
3ko0J-1ffvB:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 8 GLY A  26
CYH C  46
CYH C 135
PHE A 245
 None
FES  C1908 (-2.2A)
FES  C1907 (-2.3A)
PCD  A1920 (-3.4A)
 1.09A 3ko0B-1sb3A:
undetectable
3ko0J-1sb3A:
undetectable		 3ko0B-1sb3A:
7.84
3ko0J-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 GLY A 191
CYH A  45
CYH A 137
PHE A 421
 None
FES  A 909 (-2.3A)
FES  A 908 (-2.3A)
PCD  A 921 (-3.4A)
 1.04A 3ko0B-3fahA:
1.0
3ko0J-3fahA:
undetectable		 3ko0B-3fahA:
7.39
3ko0J-3fahA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvA-1sb3C:
undetectable		 3kvvA-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.12A 3kvvB-1sb3C:
undetectable		 3kvvB-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.15A 3kvvC-1sb3C:
undetectable		 3kvvC-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvD-1sb3C:
undetectable		 3kvvD-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.14A 3kvvE-1sb3C:
undetectable		 3kvvE-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.12A 3kvvF-1sb3C:
undetectable		 3kvvF-1sb3C:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 12 TYR A 218
GLY A 246
ALA A 356
THR A 323
ILE A  86
 None
PCD  A1920 (-3.2A)
PCD  A1920 ( 4.2A)
None
None
 1.26A 3ld6A-1sb3A:
undetectable		 3ld6A-1sb3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		5 / 11 ALA A 356
TYR A 217
ASN A 518
THR A 448
VAL A 445
 PCD  A1920 ( 4.2A)
None
None
None
None
 1.04A 3rukD-1sb3A:
undetectable		 3rukD-1sb3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 PHE A 494
GLY A 495
GLY A 422
MET A 398
 None
None
PCD  A 921 (-3.4A)
None
 0.95A 3v3nB-3fahA:
undetectable		 3v3nB-3fahA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 PHE A 494
GLY A 495
GLY A 422
MET A 398
 None
None
PCD  A 921 (-3.4A)
None
 0.95A 3v3nC-3fahA:
undetectable		 3v3nC-3fahA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 5 HIS A 653
GLY A 422
TYR A 423
GLU A 369
 PCD  A 921 (-3.7A)
PCD  A 921 (-3.4A)
None
None
 1.27A 4ae1B-3fahA:
undetectable		 4ae1B-3fahA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 10 ILE A 808
LEU A 791
GLY A 868
GLY A 866
SER A 865
 None
None
PCD  A 921 (-3.5A)
PCD  A 921 (-3.4A)
PCD  A 921 (-4.9A)
 1.24A 4bwlC-3fahA:
undetectable		 4bwlC-3fahA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 6 GLY C 139
GLN C  99
ILE A 705
VAL C 141
 None
PCD  A1920 ( 4.0A)
None
None
 1.11A 4e1vF-1sb3C:
undetectable		 4e1vF-1sb3C:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 GLY A 660
ARG A 709
ALA A 707
PRO A 183
ILE A 679
 PCD  A 921 (-3.1A)
None
None
None
None
 1.18A 4j4vA-3fahA:
undetectable		 4j4vA-3fahA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		5 / 12 ILE B 689
ILE B 688
ARG B 683
GLY B  19
ALA B  20
 PCD  B1920 (-4.7A)
PCD  B1920 (-4.4A)
None
None
None
 0.95A 4nkvA-1ffvB:
undetectable		 4nkvA-1ffvB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 5 THR B 519
THR B 561
THR B 650
HIS B 748
 None
PCD  B1920 ( 4.3A)
None
None
 1.33A 4pgfB-1ffvB:
undetectable		 4pgfB-1ffvB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLY A 246
THR A 249
HIS A 188
GLY A 355
 PCD  A1920 (-3.2A)
PCD  A1920 (-3.8A)
None
None
 1.10A 4v20A-1sb3A:
undetectable		 4v20A-1sb3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 7 SER B 386
SER B 564
GLU B 482
GLU B 757
 CSZ  B 385 ( 3.5A)
PCD  B1920 (-4.0A)
None
PCD  B1920 (-3.2A)
 1.12A 4xzkA-1ffvB:
undetectable		 4xzkA-1ffvB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 11 GLY A 697
GLN A 655
ARG A 533
PHE A 421
GLY A 422
 GOL  A 912 ( 3.1A)
PCD  A 921 (-3.6A)
PCD  A 921 (-4.0A)
PCD  A 921 (-3.4A)
PCD  A 921 (-3.4A)
 1.19A 5b1bA-3fahA:
0.0
5b1bB-3fahA:
0.0
5b1bT-3fahA:
0.0		 5b1bA-3fahA:
21.15
5b1bB-3fahA:
13.55
5b1bT-3fahA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3fah ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 6 SER A 692
GLU A 633
GLY A 656
GLY A 660
 None
None
PCD  A 921 (-3.2A)
PCD  A 921 (-3.1A)
 0.76A 5cdnA-3fahA:
undetectable
5cdnB-3fahA:
undetectable		 5cdnA-3fahA:
20.05
5cdnB-3fahA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		3 / 3 GLY B 266
GLN B 524
LYS B 271
 PCD  B1920 (-3.6A)
PCD  B1920 (-3.5A)
None
 0.99A 5imsB-1ffvB:
undetectable		 5imsB-1ffvB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 7 ASP B  27
PHE B  30
GLY B 523
GLY B 525
 None
None
PCD  B1920 (-3.6A)
PCD  B1920 ( 4.2A)
 1.02A 5n9xA-1ffvB:
undetectable		 5n9xA-1ffvB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		5 / 11 ARG A 358
GLY A 243
GLY A 484
GLN C  99
THR C  98
 PCD  A1920 (-3.8A)
PCD  A1920 (-3.4A)
PCD  A1920 (-3.7A)
PCD  A1920 ( 4.0A)
None
 1.41A 5w97G-1sb3A:
0.0
5w97a-1sb3A:
0.0
5w97b-1sb3A:
0.0		 5w97G-1sb3A:
7.68
5w97a-1sb3A:
22.04
5w97b-1sb3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.21A 6aphA-1sb3C:
undetectable		 6aphA-1sb3C:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		4 / 7 GLN B 522
GLY B 754
SER B 566
VAL B 484
 PCD  B1920 (-4.2A)
PCD  B1920 (-3.6A)
PCD  B1920 (-2.7A)
None
 0.71A 6ekzA-1ffvB:
0.0		 6ekzA-1ffvB:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 4 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.22A 6f3mA-1sb3C:
undetectable		 6f3mA-1sb3C:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 4 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.24A 6f3mC-1sb3C:
undetectable		 6f3mC-1sb3C:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 6 ASP A 480
ASP A  19
GLN C  99
LYS A  23
 None
None
PCD  A1920 ( 4.0A)
None
 1.33A 6g31L-1sb3A:
undetectable		 6g31L-1sb3A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica) 		4 / 5 GLN C  99
THR C  98
THR C 149
LEU A 657
 PCD  A1920 ( 4.0A)
None
None
None
 1.22A 6gbnB-1sb3C:
undetectable		 6gbnB-1sb3C:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT
(Thauera
aromatica;
Thauera
aromatica) 		4 / 6 LEU A 241
CYH C 100
GLY A 244
ARG A 248
 None
FES  C1907 (-2.1A)
PCD  A1920 (-3.6A)
None
 1.19A 6gtqB-1sb3A:
undetectable
6gtqD-1sb3A:
undetectable		 6gtqB-1sb3A:
12.95
6gtqD-1sb3A:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
(Hydrogenophaga
pseudoflava) 		5 / 12 VAL B 755
ASP B 739
PHE B 480
TYR B 656
ILE B 655
 PCD  B1920 (-4.1A)
None
None
None
None
 1.35A 6mxtA-1ffvB:
0.0		 6mxtA-1ffvB:
19.46