SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PBZ'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
6 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.90A 1aq7A-1fiwA:
34.4
1aq7A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.68A 1aq7A-1fizA:
33.8
1aq7A-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
5 / 9 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.38A 1bcuH-1fiwA:
35.4
1bcuH-1fiwA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 9 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.52A 1bcuH-1fizA:
17.5
1bcuH-1fizA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.3A)
0.47A 1dwcH-1fiwA:
34.8
1dwcH-1fiwA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 ( 3.7A)
0.41A 1dwcH-1fizA:
34.3
1dwcH-1fizA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.60A 1etrH-1fiwA:
34.7
1etrH-1fiwA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.54A 1etrH-1fizA:
34.1
1etrH-1fizA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.30A 1f5lA-1fiwA:
36.6
1f5lA-1fiwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.43A 1f5lA-1fizA:
36.3
1f5lA-1fizA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.35A 1tnlA-1fiwA:
16.2
1tnlA-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.32A 1tnlA-1fizA:
17.0
1tnlA-1fizA:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
5 / 10 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
PBZ  A 305 (-3.9A)
None
None
None
None
1.10A 1x7pA-1fiwA:
undetectable
1x7pB-1fiwA:
undetectable
1x7pA-1fiwA:
23.03
1x7pB-1fiwA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 10 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
PBZ  A 308 (-3.4A)
None
None
None
None
1.02A 1x7pA-1fizA:
undetectable
1x7pB-1fizA:
undetectable
1x7pA-1fizA:
19.47
1x7pB-1fizA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.23A 2otvA-1fiwA:
16.4
2otvA-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.36A 2otvA-1fizA:
17.1
2otvA-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
None
0.30A 2p16A-1fiwA:
35.3
2p16A-1fiwA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
None
0.41A 2p16A-1fizA:
34.1
2p16A-1fizA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.34A 2vinA-1fiwA:
37.1
2vinA-1fiwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.33A 2vinA-1fizA:
14.1
2vinA-1fizA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
7 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-4.9A)
PBZ  A 305 (-3.3A)
None
0.34A 2w26A-1fiwA:
35.4
2w26A-1fiwA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
7 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
None
PBZ  A 308 ( 3.7A)
None
0.50A 2w26A-1fizA:
16.2
2w26A-1fizA:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 11 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
PBZ  A 308 (-3.4A)
None
None
None
None
0.97A 3dcmX-1fizA:
undetectable
3dcmX-1fizA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
6 / 11 ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.81A 3gy3A-1fiwA:
16.4
3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.37A 3gy3A-1fiwA:
16.4
3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
7 / 11 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.56A 3gy3A-1fizA:
16.9
3gy3A-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.28A 3rxfA-1fiwA:
16.9
3rxfA-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.28A 3rxfA-1fizA:
16.5
3rxfA-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
None
PBZ  A 308 (-3.6A)
None
PBZ  A 308 (-3.2A)
0.87A 4fu8A-1fizA:
36.4
4fu8A-1fizA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
3 / 3 ASP A 102
TRP A  63
SER A 195
None
None
PBZ  A 305 (-2.9A)
1.06A 4lrhB-1fiwA:
undetectable
4lrhB-1fiwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 ASP A 102
TRP A  63
SER A 195
None
None
PBZ  A 308 (-3.2A)
1.07A 4lrhB-1fizA:
undetectable
4lrhB-1fizA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 7 THR A 190
GLY A 216
TYR A 228
GLY A 226
PBZ  A 308 (-3.4A)
PBZ  A 308 (-3.6A)
None
PBZ  A 308 ( 3.7A)
0.91A 4rdxA-1fizA:
undetectable
4rdxA-1fizA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
None
None
None
PBZ  A 305 (-2.9A)
None
0.95A 6c2mC-1fiwA:
9.7
6c2mC-1fiwA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
None
None
None
PBZ  A 308 (-3.2A)
None
0.88A 6c2mC-1fizA:
9.5
6c2mC-1fizA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis
aries)
4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
PBZ  A 305 (-3.4A)
None
PBZ  A 305 (-2.9A)
None
0.76A 6hu9H-1fiwA:
undetectable
6hu9e-1fiwA:
undetectable
6hu9H-1fiwA:
14.79
6hu9e-1fiwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
PBZ  A 308 (-3.6A)
None
PBZ  A 308 (-3.2A)
None
0.78A 6hu9H-1fizA:
undetectable
6hu9e-1fizA:
undetectable
6hu9H-1fizA:
12.98
6hu9e-1fizA:
19.77