SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PBD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 7 GLU A 171
TRP A 296
LEU A 219
TRP A 176
 ZN  A 401 ( 2.1A)
ZN  A 401 (-4.8A)
None
PBD  A 402 (-4.0A)
 1.31A 1q0yH-4f9uA:
undetectable
1q0yL-4f9uA:
undetectable		 1q0yH-4f9uA:
20.52
1q0yL-4f9uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 SER A 154
PHE A 281
LEU A 185
ASP A 294
GLU A 190
 None
None
None
None
PBD  A 402 (-3.5A)
 1.39A 3aocC-4faiA:
undetectable		 3aocC-4faiA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 8 ASP A 131
LEU A 219
ASP A 272
ASP A 273
 ZN  A 401 ( 2.3A)
None
PBD  A 402 ( 4.3A)
None
 1.22A 3n2oC-4f9uA:
undetectable
3n2oD-4f9uA:
undetectable		 3n2oC-4f9uA:
18.41
3n2oD-4f9uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 ASP A 153
LEU A 229
ASP A 293
ASP A 294
 ZN  A 401 ( 2.1A)
PBD  A 402 (-4.8A)
PBD  A 402 ( 4.1A)
None
 1.21A 3n2oC-4faiA:
undetectable
3n2oD-4faiA:
undetectable		 3n2oC-4faiA:
19.66
3n2oD-4faiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 6 HIS A 297
PRO A 293
LEU A 219
ASP A 272
 ZN  A 401 ( 3.1A)
None
None
PBD  A 402 ( 4.3A)
 1.16A 3oi8A-4f9uA:
undetectable		 3oi8A-4f9uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 6 HIS A 318
PRO A 314
LEU A 229
ASP A 293
 ZN  A 401 ( 3.2A)
None
PBD  A 402 (-4.8A)
PBD  A 402 ( 4.1A)
 1.13A 3oi8A-4faiA:
undetectable		 3oi8A-4faiA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.50A 3ximC-4f9uA:
undetectable		 3ximC-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 11 HIS A 114
ASP A 131
GLU A 170
GLU A 171
HIS A 297
 None
ZN  A 401 ( 2.3A)
PBD  A 402 (-3.4A)
ZN  A 401 ( 2.1A)
ZN  A 401 ( 3.1A)
 0.34A 4pqaA-4f9uA:
21.9		 4pqaA-4f9uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 11 HIS A 137
ASP A 153
GLU A 190
GLU A 191
HIS A 318
 None
ZN  A 401 ( 2.1A)
PBD  A 402 (-3.5A)
ZN  A 401 ( 2.2A)
ZN  A 401 ( 3.2A)
 0.32A 4pqaA-4faiA:
22.1		 4pqaA-4faiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 5 LEU A 229
LEU A 226
PHE A 313
HIS A 137
 PBD  A 402 (-4.8A)
None
PBD  A 402 (-3.8A)
None
 0.95A 5gtrA-4faiA:
undetectable		 5gtrA-4faiA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		3 / 3 LEU A 230
LEU A 229
TRP A 317
 None
PBD  A 402 (-4.8A)
PBD  A 402 (-4.7A)
 0.93A 5nwuA-4faiA:
undetectable		 5nwuA-4faiA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.50A 5ximA-4f9uA:
undetectable		 5ximA-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.49A 5ximC-4f9uA:
undetectable		 5ximC-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLU A 190
HIS A 137
ASP A 294
ASP A 153
ASP A 293
 PBD  A 402 (-3.5A)
None
None
ZN  A 401 ( 2.1A)
PBD  A 402 ( 4.1A)
 1.49A 5ximC-4faiA:
undetectable		 5ximC-4faiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.49A 5ximD-4f9uA:
undetectable		 5ximD-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLU A 190
HIS A 137
ASP A 294
ASP A 153
ASP A 293
 PBD  A 402 (-3.5A)
None
None
ZN  A 401 ( 2.1A)
PBD  A 402 ( 4.1A)
 1.50A 5ximD-4faiA:
undetectable		 5ximD-4faiA:
23.41