SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PAR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_F_THAF6_1 (LIVER CARBOXYLESTERASE I)	4qb9	ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycolicibacteriu m smegmatis)	5 / 12	GLY A 124 GLY A 123 SER A 121 LEU A 97 PHE A 26	None None PAR A 500 (-3.0A) None PAR A 500 (-3.7A)	0.97A	1mx1F-4qb9A: undetectable	1mx1F-4qb9A: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_C_ACTC403_0 (D-ALANINE--D-ALANINE LIGASE)	4qb9	ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycolicibacteriu m smegmatis)	4 / 4	TYR A 101 GLY A 81 SER A 83 LEU A 118	None None PAR A 500 (-4.4A) PAR A 500 ( 4.5A)	1.32A	5bphC-4qb9A: undetectable	5bphC-4qb9A: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_G_EVPG2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4qb9	ENHANCED INTRACELLULAR SURVIVAL PROTEIN (Mycolicibacteriu m smegmatis)	5 / 6	SER A 121 GLU A 122 GLY A 130 ARG A 128 GLY A 127	PAR A 500 (-3.0A) None None None None	1.49A	5cdnA-4qb9A: undetectable 5cdnB-4qb9A: undetectable	5cdnA-4qb9A: 21.00 5cdnB-4qb9A: 20.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_F_THAF6_1","LIVER CARBOXYLESTERASE I","4qb9","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","Mycolicibacterium smegmatis",5,"GLY A 124;GLY A 123;SER A 121;LEU A  97;PHE A  26","None;None;PAR A 500 (-3.0A);None;PAR A 500 (-3.7A)","0.97A","1mx1F-4qb9A:undetectable",null],["5BPH_C_ACTC403_0","D-ALANINE--D-ALANINE LIGASE","4qb9","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","Mycolicibacterium smegmatis",4,"TYR A 101;GLY A  81;SER A  83;LEU A 118","None;None;PAR A 500 (-4.4A);PAR A 500 ( 4.5A)","1.32A","5bphC-4qb9A:undetectable","1mx1F-4qb9A:21.69"],["5CDN_G_EVPG2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","4qb9","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","Mycolicibacterium smegmatis",5,"SER A 121;GLU A 122;GLY A 130;ARG A 128;GLY A 127","PAR A 500 (-3.0A);None;None;None;None","1.49A","5cdnA-4qb9A:undetectable;5cdnB-4qb9A:undetectable","5bphC-4qb9A:22.35"]]