SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PAQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		8 / 10 TYR A 372
THR A 467
ASN A 470
ASP A 472
TYR A 473
HIS A 520
HIS A 522
HIS A 684
 None
PAQ  A 471 ( 4.4A)
PAQ  A 471 ( 3.3A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
 0.66A 1ivvA-2c11A:
39.3		 1ivvA-2c11A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		8 / 10 TYR A 372
THR A 467
ASN A 470
ASP A 472
TYR A 473
HIS A 520
HIS A 522
HIS A 684
 None
PAQ  A 471 ( 4.4A)
PAQ  A 471 ( 3.3A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
 0.69A 1ivvB-2c11A:
39.3		 1ivvB-2c11A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 520
GLY A 517
PHE A 682
ASN A 470
 CU  A1737 (-3.4A)
None
None
PAQ  A 471 ( 3.3A)
 0.88A 2a8tB-2c11A:
undetectable		 2a8tB-2c11A:
14.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		6 / 7 ALA A 370
TYR A 372
TYR A 384
ASP A 386
TYR A 473
HIS A 522
 PAQ  A 471 ( 3.2A)
None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.1A)
 0.32A 2pncA-2c11A:
55.2		 2pncA-2c11A:
81.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 6 ALA A 370
TYR A 384
ASP A 386
TYR A 473
HIS A 522
 PAQ  A 471 ( 3.2A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.1A)
 0.31A 2pncB-2c11A:
58.1		 2pncB-2c11A:
81.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 TYR A 176
TYR A 384
ASP A 386
GLY A 390
ASN A 470
 None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
None
PAQ  A 471 ( 3.3A)
 0.82A 3hiiA-2c11A:
53.5		 3hiiA-2c11A:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 TYR A 176
TYR A 384
ASP A 386
GLY A 390
ASN A 470
 None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
None
PAQ  A 471 ( 3.3A)
 0.78A 3hiiB-2c11A:
51.4		 3hiiB-2c11A:
39.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 PHE A 526
TYR A 473
VAL A 701
GLY A 702
SER A 609
 None
PAQ  A 471 ( 4.5A)
None
None
None
 1.34A 4ot2A-2c11A:
undetectable		 4ot2A-2c11A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 TYR A 394
LEU A 468
ALA A 368
ILE A 127
SER A 645
 None
PAQ  A 471 ( 3.4A)
None
None
None
 1.13A 5h8tA-2c11A:
undetectable		 5h8tA-2c11A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens) 		5 / 8 PHE A 625
HIS A 525
GLY A 681
SER A 523
ALA A 370
 None
None
None
None
PAQ  A 471 ( 3.2A)
 1.19A 6hu9H-2c11A:
undetectable
6hu9e-2c11A:
undetectable		 6hu9H-2c11A:
8.31
6hu9e-2c11A:
13.76