SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PAP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 7 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 1.00A 3ln1C-3mgbA:
undetectable		 3ln1C-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 0.98A 3ln1D-3mgbA:
undetectable		 3ln1D-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 HIS A  67
ALA A  13
SER A   9
TYR A  87
 None
PAP  A 286 (-4.8A)
PAP  A 286 ( 4.7A)
None
 1.48A 5yodF-3mgbA:
undetectable		 5yodF-3mgbA:
20.79