SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PAM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 ALA A  39
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 (-3.3A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 1.09A 1cbrA-5bvtA:
18.9		 1cbrA-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.73A 1cbrA-5bvtA:
18.9		 1cbrA-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 ALA A  39
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 (-3.3A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 1.09A 1cbrB-5bvtA:
18.9		 1cbrB-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.73A 1cbrB-5bvtA:
18.9		 1cbrB-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.76A 1cbsA-5bvtA:
18.7		 1cbsA-5bvtA:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 6c0b FRIZZLED-2
TOXIN B
(Clostridioides
difficile;
Homo
sapiens) 		4 / 7 LEU B 124
MET A1437
LEU A1433
GLU A1471
 PAM  B 202 ( 4.6A)
PAM  B 202 (-3.6A)
PAM  B 202 (-4.2A)
None
 0.94A 1linA-6c0bB:
undetectable		 1linA-6c0bB:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
TYR A  20
ALA A  34
PRO A  39
THR A  54
 None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
PAM  A 133 ( 3.9A)
 0.98A 1mx8A-3pp6A:
17.7		 1mx8A-3pp6A:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3leo LEUKOTRIENE C4
SYNTHASE
(Homo
sapiens) 		5 / 9 ALA A  10
LEU A  14
GLY A  15
PHE A  63
GLY A  83
 PAM  A 215 (-3.7A)
PAM  A 215 (-3.9A)
None
None
None
 1.34A 1ru9H-3leoA:
undetectable
1ru9L-3leoA:
undetectable		 1ru9H-3leoA:
21.33
1ru9L-3leoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3leo LEUKOTRIENE C4
SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A  10
LEU A  14
GLY A  15
PHE A  63
GLY A  83
 PAM  A 215 (-3.7A)
PAM  A 215 (-3.9A)
None
None
None
 1.35A 1ruaH-3leoA:
undetectable
1ruaL-3leoA:
undetectable		 1ruaH-3leoA:
21.33
1ruaL-3leoA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
THR A  56
GLY A  80
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
None
None
PAM  A 201 ( 4.6A)
None
 0.86A 2cbrA-5bvtA:
19.1		 2cbrA-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.77A 2fr3A-5bvtA:
18.9		 2fr3A-5bvtA:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		7 / 12 PHE A  17
VAL A  26
ALA A  34
THR A  61
ASP A  77
ARG A  79
ARG A 126
 None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-3.7A)
PAM  A 133 (-4.3A)
None
PAM  A 133 (-3.9A)
 0.26A 2qm9A-3pp6A:
23.1		 2qm9A-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		8 / 12 PHE A  19
VAL A  28
SER A  58
ASP A  79
ARG A  81
CYH A 121
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
None
PAM  A 201 ( 3.9A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.0A)
PAM  A 201 ( 4.6A)
None
 0.55A 2qm9A-5bvtA:
24.8		 2qm9A-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		6 / 12 VAL A  28
SER A  58
ASP A  79
CYH A 128
ARG A 130
TYR A 132
 None
PAM  A 201 ( 3.9A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.6A)
None
 1.43A 2qm9A-5bvtA:
24.8		 2qm9A-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 VAL A  28
THR A  56
ASP A  79
ARG A  81
CYH A 121
 None
None
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.0A)
 1.07A 2qm9A-5bvtA:
24.8		 2qm9A-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		4 / 4 TYR A  22
MET A  23
PRO A  41
ILE A 108
 None
PAM  A 201 ( 3.8A)
PAM  A 201 ( 4.8A)
PAM  A 201 ( 4.7A)
 0.41A 2qm9A-5bvtA:
24.8		 2qm9A-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
THR A  61
ARG A  79
ARG A 126
 None
None
None
PAM  A 133 (-3.7A)
None
PAM  A 133 (-3.9A)
 0.43A 2qm9B-3pp6A:
23.8		 2qm9B-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		5 / 12 PHE A  19
TYR A  22
SER A  63
ILE A 108
CYH A 121
 PAM  A 201 ( 4.9A)
None
None
PAM  A 201 ( 4.7A)
PAM  A 201 ( 4.0A)
 1.25A 2qm9B-5bvtA:
25.2		 2qm9B-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		9 / 12 PHE A  19
TYR A  22
VAL A  28
SER A  58
ARG A  81
ILE A 108
CYH A 121
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
None
None
PAM  A 201 ( 3.9A)
None
PAM  A 201 ( 4.7A)
PAM  A 201 ( 4.0A)
PAM  A 201 ( 4.6A)
None
 0.49A 2qm9B-5bvtA:
25.2		 2qm9B-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		6 / 12 TYR A  22
VAL A  28
THR A  56
ARG A  81
ILE A 108
CYH A 121
 None
None
None
None
PAM  A 201 ( 4.7A)
PAM  A 201 ( 4.0A)
 0.97A 2qm9B-5bvtA:
25.2		 2qm9B-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 4 MET A  21
PRO A  39
ASP A  77
ARG A 106
 PAM  A 133 ( 3.9A)
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
 0.39A 2qm9B-3pp6A:
23.8		 2qm9B-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		4 / 4 MET A  23
PRO A  41
ASP A  79
ARG A 110
 PAM  A 201 ( 3.8A)
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
PAM  A 201 ( 4.6A)
 0.25A 2qm9B-5bvtA:
25.2		 2qm9B-5bvtA:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A  25
ILE A 222
PHE A 255
SER A 257
VAL A  83
 None
None
None
None
PAM  A 304 ( 4.8A)
 1.41A 3a9eB-4mloA:
undetectable		 3a9eB-4mloA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		8 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 106
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
None
PAM  A 133 (-3.9A)
 0.44A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
CYH A 124
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.08A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
VAL A  24
PRO A  39
CYH A 124
ARG A 126
 None
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.37A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		12 / 12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 108
ARG A 110
VAL A 119
CYH A 121
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 3.8A)
None
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.7A)
PAM  A 201 ( 4.6A)
None
PAM  A 201 ( 4.0A)
PAM  A 201 ( 4.6A)
None
 0.65A 3p6gA-5bvtA:
24.5		 3p6gA-5bvtA:
52.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		8 / 12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
CYH A 128
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 3.8A)
None
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.6A)
None
 1.08A 3p6gA-5bvtA:
24.5		 3p6gA-5bvtA:
52.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 7 PHE A  17
MET A  21
ASP A  77
ARG A 126
 None
PAM  A 133 ( 3.9A)
PAM  A 133 (-4.3A)
PAM  A 133 (-3.9A)
 0.44A 3p6hA-3pp6A:
23.1		 3p6hA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN
(Pygoscelis
papua) 		7 / 7 PHE A  19
MET A  23
ASP A  79
ILE A 108
VAL A 119
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 3.8A)
PAM  A 201 (-4.0A)
PAM  A 201 ( 4.7A)
None
PAM  A 201 ( 4.6A)
None
 0.46A 3p6hA-5bvtA:
24.5		 3p6hA-5bvtA:
52.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 5 LEU A  78
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.31A 3vm4A-1izoA:
59.0		 3vm4A-1izoA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		4 / 7 ASP A 317
PHE A 292
GLY A 290
THR A 321
 None
PAM  A 601 (-4.9A)
PAM  A 601 ( 4.0A)
None
 1.04A 3vnsA-1izoA:
undetectable		 3vnsA-1izoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A  58
SER A  56
ILE A  79
LEU A  71
LEU A 114
 None
None
None
PAM  A 304 ( 4.9A)
None
 1.33A 3vw1B-4mloA:
3.5		 3vw1B-4mloA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 11 TRP A 193
PHE A 166
ILE A 244
ALA A 246
SER A 248
 None
None
HEM  A 501 ( 4.7A)
PAM  A 601 (-3.9A)
None
 1.44A 4m83B-1izoA:
undetectable		 4m83B-1izoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 8 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PAM  A 133 ( 3.9A)
PAM  A 133 (-3.7A)
 0.91A 4n16A-3pp6A:
undetectable		 4n16A-3pp6A:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
MET A  21
ALA A  34
THR A  54
LEU A 117
 None
PAM  A 133 ( 3.9A)
PAM  A 133 ( 3.7A)
PAM  A 133 ( 3.9A)
None
 0.66A 4qzuC-3pp6A:
21.7		 4qzuC-3pp6A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3leo LEUKOTRIENE C4
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A  79
LEU A   8
LEU A   7
LEU A 118
 PAM  A 215 ( 4.5A)
None
None
PAM  A 215 ( 4.1A)
None
 1.13A 4zn7A-3leoA:
undetectable		 4zn7A-3leoA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
 None
None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
None
 0.73A 5hbsA-3pp6A:
21.0		 5hbsA-3pp6A:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 10 LEU A  78
ARG A 242
PRO A 243
ALA A 246
PHE A 289
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
HEM  A 501 ( 4.0A)
 0.30A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 10 LEU A  78
PHE A 173
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 ( 4.2A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.65A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 8 LEU A  78
ARG A 242
PRO A 243
ALA A 246
PHE A 289
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
HEM  A 501 ( 4.0A)
 0.31A 5m0oC-1izoA:
56.5		 5m0oC-1izoA:
41.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1izo CYTOCHROME P450
152A1
(Bacillus
subtilis) 		5 / 8 LEU A  78
PHE A 173
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 ( 4.2A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.66A 5m0oC-1izoA:
56.5		 5m0oC-1izoA:
41.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 7 THR A  56
LYS A  22
ASN A  35
GLU A  15
 PAM  A 133 ( 4.6A)
None
None
None
 0.87A 5tudA-3pp6A:
undetectable		 5tudA-3pp6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6c0b FRIZZLED-2
TOXIN B
(Clostridioides
difficile;
Homo
sapiens) 		5 / 12 LEU A1488
ASP A1490
LEU A1527
VAL A1518
PHE B 128
 None
None
None
None
PAM  B 202 (-3.9A)
 1.04A 5uxdB-6c0bA:
undetectable		 5uxdB-6c0bA:
12.87