SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PAH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M4I_A_KANA500_1 (AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERA SE)	2ptz	ENOLASE (Trypanosoma brucei)	5 / 8	GLU A 208 GLY A 396 SER A 370 ASP A 318 ASP A 243	PAH A 600 ( 4.8A) None PAH A 600 ( 4.2A) ZN A 500 ( 3.0A) ZN A 500 ( 2.4A)	1.50A	1m4iA-2ptzA: undetectable	1m4iA-2ptzA: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N2O_C_AG2C1002_1 (BIOSYNTHETIC ARGININE DECARBOXYLASE)	2ptz	ENOLASE (Trypanosoma brucei)	4 / 8	HIS A 371 SER A 373 ASP A 243 ASP A 318	None PAH A 600 (-2.4A) ZN A 500 ( 2.4A) ZN A 500 ( 3.0A)	1.27A	3n2oC-2ptzA: 6.8 3n2oD-2ptzA: 3.3	3n2oC-2ptzA: 21.04 3n2oD-2ptzA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J26_B_ESTB600_1 (ESTROGEN RECEPTOR BETA)	2ptz	ENOLASE (Trypanosoma brucei)	5 / 12	LEU A 340 LEU A 341 ILE A 381 ILE A 393 LEU A 388	None PAH A 600 (-4.8A) None None None	1.30A	4j26B-2ptzA: undetectable	4j26B-2ptzA: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LV9_A_20JA601_1 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	2ptz	ENOLASE (Trypanosoma brucei)	4 / 8	ARG A 403 ASP A 207 ALA A 39 SER A 40	None None PAH A 600 (-3.6A) ZN A 501 ( 2.1A)	1.00A	4lv9A-2ptzA: 2.9 4lv9B-2ptzA: 3.5	4lv9A-2ptzA: 22.33 4lv9B-2ptzA: 22.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1M4I_A_KANA500_1","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","2ptz","ENOLASE","Trypanosoma brucei",5,"GLU A 208;GLY A 396;SER A 370;ASP A 318;ASP A 243","PAH A 600 ( 4.8A);None;PAH A 600 ( 4.2A); ZN A 500 ( 3.0A); ZN A 500 ( 2.4A)","1.50A","1m4iA-2ptzA:undetectable",null],["3N2O_C_AG2C1002_1","BIOSYNTHETIC ARGININE DECARBOXYLASE;BIOSYNTHETIC ARGININE DECARBOXYLASE","2ptz","ENOLASE","Trypanosoma brucei",4,"HIS A 371;SER A 373;ASP A 243;ASP A 318","None;PAH A 600 (-2.4A); ZN A 500 ( 2.4A); ZN A 500 ( 3.0A)","1.27A","3n2oC-2ptzA:6.8;3n2oD-2ptzA:3.3","1m4iA-2ptzA:17.05"],["4J26_B_ESTB600_1","ESTROGEN RECEPTOR BETA","2ptz","ENOLASE","Trypanosoma brucei",5,"LEU A 340;LEU A 341;ILE A 381;ILE A 393;LEU A 388","None;PAH A 600 (-4.8A);None;None;None","1.30A","4j26B-2ptzA:undetectable","3n2oC-2ptzA:21.04;3n2oD-2ptzA:21.04"],["4LV9_A_20JA601_1","NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE","2ptz","ENOLASE","Trypanosoma brucei",4,"ARG A 403;ASP A 207;ALA A  39;SER A  40","None;None;PAH A 600 (-3.6A); ZN A 501 ( 2.1A)","1.00A","4lv9A-2ptzA:2.9;4lv9B-2ptzA:3.5","4j26B-2ptzA:20.71"]]