SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PA5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		5 / 12 GLY A 188
PHE A 205
ALA A 224
SER A 159
ILE A 156
 None
None
None
PA5  A 600 (-3.4A)
None
 1.24A 5ih0A-1gzvA:
0.0		 5ih0A-1gzvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		3 / 3 GLY A 270
GLY A 271
GLN A 511
 None
PA5  A 600 ( 4.3A)
PA5  A 600 ( 4.2A)
 0.40A 5imsA-1gzvA:
4.8		 5imsA-1gzvA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		5 / 12 THR A 167
PHE A 205
ALA A 224
SER A 159
ILE A 156
 None
None
None
PA5  A 600 (-3.4A)
None
 1.35A 5iwuA-1gzvA:
0.0		 5iwuA-1gzvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		3 / 3 LEU A 161
THR A 217
ASN A 220
 None
PA5  A 600 ( 4.3A)
None
 0.67A 6baaE-1gzvA:
0.0		 6baaE-1gzvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		3 / 3 LEU A 161
THR A 217
ASN A 220
 None
PA5  A 600 ( 4.3A)
None
 0.67A 6baaF-1gzvA:
0.0		 6baaF-1gzvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		3 / 3 LEU A 161
THR A 217
ASN A 220
 None
PA5  A 600 ( 4.3A)
None
 0.67A 6baaG-1gzvA:
0.0		 6baaG-1gzvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		3 / 3 LEU A 161
THR A 217
ASN A 220
 None
PA5  A 600 ( 4.3A)
None
 0.68A 6baaH-1gzvA:
0.0		 6baaH-1gzvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE
(Sus
scrofa) 		4 / 6 SER A 159
ALA A 278
SER A 277
ALA A 208
 PA5  A 600 (-3.4A)
None
None
None
 0.84A 6bocA-1gzvA:
undetectable
6bocB-1gzvA:
undetectable
6bocC-1gzvA:
undetectable
6bocD-1gzvA:
undetectable		 6bocA-1gzvA:
3.95
6bocB-1gzvA:
3.95
6bocC-1gzvA:
3.95
6bocD-1gzvA:
3.95