SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PA1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 7 PHE A  94
TYR A 168
PRO A 167
THR A 169
 None
PA1  A 401 (-3.1A)
None
None
 1.25A 2q6kA-4y9tA:
3.8		 2q6kA-4y9tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 8 GLY A 175
GLN A 173
TYR A 168
SER A 248
 None
None
PA1  A 401 (-3.1A)
None
 0.94A 4wryA-4y9tA:
2.9		 4wryA-4y9tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		4 / 8 GLY A 175
GLN A 173
TYR A 168
SER A 248
 None
None
PA1  A 401 (-3.1A)
None
 0.95A 4wrzA-4y9tA:
2.9		 4wrzA-4y9tA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)		 4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN
(Agrobacterium
vitis) 		11 / 11 ASP A  39
PHE A  41
GLN A  42
ASP A 115
ARG A 116
ASP A 166
TYR A 168
TRP A 196
HIS A 224
ASN A 249
GLN A 269
 PA1  A 401 (-2.8A)
PA1  A 401 (-3.6A)
PA1  A 401 (-3.8A)
PA1  A 401 (-3.0A)
PA1  A 401 (-4.0A)
PA1  A 401 (-3.1A)
PA1  A 401 (-3.1A)
PA1  A 401 (-3.6A)
PA1  A 401 (-4.5A)
PA1  A 401 (-4.0A)
PA1  A 401 (-3.0A)
 0.15A 5br1A-4y9tA:
55.4		 5br1A-4y9tA:
100.00