SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P6T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ASN A 253
GLU A 133
HIS A 210
ALA A 169
 P6T  A 327 (-3.8A)
None
ZN  A 326 ( 3.3A)
None
 0.92A 2bnnA-3gayA:
undetectable
2bnnB-3gayA:
undetectable		 2bnnA-3gayA:
20.12
2bnnB-3gayA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ILE A 241
ALA A  13
VAL A 254
PHE A 301
SER A  43
 None
None
P6T  A 327 (-4.3A)
None
None
 1.20A 2gl0A-3gayA:
undetectable
2gl0C-3gayA:
undetectable		 2gl0A-3gayA:
18.90
2gl0C-3gayA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 PHE A 301
SER A  43
ILE A 241
ALA A  13
VAL A 254
 None
None
None
None
P6T  A 327 (-4.3A)
 1.28A 2gl0D-3gayA:
undetectable
2gl0E-3gayA:
undetectable		 2gl0D-3gayA:
18.90
2gl0E-3gayA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		5 / 12 ASN A  24
THR A 176
VAL A 236
ILE A 241
ILE A 252
 P6T  A 327 (-3.5A)
None
None
None
None
 1.22A 3kpbA-3gayA:
undetectable		 3kpbA-3gayA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A 238
ILE A 241
VAL A 254
GLY A  21
 None
None
P6T  A 327 (-4.3A)
None
 0.71A 4acaC-3gayA:
2.1		 4acaC-3gayA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A  34
GLY A  33
VAL A 254
SER A 214
 None
None
P6T  A 327 (-4.3A)
None
 0.80A 4acbB-3gayA:
undetectable
4acbC-3gayA:
2.8		 4acbB-3gayA:
22.63
4acbC-3gayA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Giardia
intestinalis) 		4 / 8 ILE A 238
ILE A 241
VAL A 254
GLY A  21
 None
None
P6T  A 327 (-4.3A)
None
 0.72A 4acbC-3gayA:
2.8		 4acbC-3gayA:
22.63