SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P6L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2
(Homo
sapiens) 		6 / 12 ALA B 349
ASP B 350
LEU B 353
LEU B 386
ARG B 393
LEU B 517
 P6L  B 100 ( 3.9A)
None
None
P6L  B 100 (-3.8A)
None
P6L  B 100 (-4.1A)
 1.18A 2jfaB-3tx7B:
19.2		 2jfaB-3tx7B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2
(Homo
sapiens) 		5 / 12 ALA B 349
LEU B 386
ILE B 387
ARG B 393
LEU B 405
 P6L  B 100 ( 3.9A)
P6L  B 100 (-3.8A)
None
None
None
 0.80A 4k6iA-3tx7B:
21.7		 4k6iA-3tx7B:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 183
SER A 204
ILE A 205
PHE A 208
MET A 228
 None
P6L  A 501 (-3.4A)
None
None
None
 1.39A 5iwuA-6fm9A:
undetectable		 5iwuA-6fm9A:
undetectable