SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P5F'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.82A 1av2A-4nmeA:
undetectable
1av2B-4nmeA:
undetectable		 1av2A-4nmeA:
2.23
1av2B-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 ALA A 272
VAL A 321
TRP A 305
 None
None
P5F  A1001 (-3.7A)
 0.89A 1av2A-5ur2A:
undetectable
1av2B-5ur2A:
undetectable		 1av2A-5ur2A:
2.82
1av2B-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.84A 1av2C-4nmeA:
undetectable
1av2D-4nmeA:
undetectable		 1av2C-4nmeA:
2.23
1av2D-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 TRP A 305
ALA A 272
VAL A 321
 P5F  A1001 (-3.7A)
None
None
 0.91A 1av2C-5ur2A:
undetectable
1av2D-5ur2A:
undetectable		 1av2C-5ur2A:
2.82
1av2D-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 0.95A 1s9pA-4nmeA:
undetectable		 1s9pA-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 0.91A 1s9pC-4nmeA:
undetectable		 1s9pC-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 1.01A 1s9pD-4nmeA:
undetectable		 1s9pD-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 5 LYS A 203
ALA A 308
TYR A 418
ARG A 422
 P5F  A1101 (-1.3A)
P5F  A1101 (-3.2A)
None
None
 0.94A 1tj2A-4nmeA:
39.4		 1tj2A-4nmeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		4 / 5 LYS A 196
ALA A 303
TYR A 413
ARG A 417
 P5F  A1001 (-1.3A)
P5F  A1001 (-3.4A)
None
None
 0.98A 1tj2A-5ur2A:
39.9		 1tj2A-5ur2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.84A 1w5uA-4nmeA:
undetectable
1w5uB-4nmeA:
undetectable		 1w5uA-4nmeA:
2.23
1w5uB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 ALA A 272
VAL A 321
TRP A 305
 None
None
P5F  A1001 (-3.7A)
 0.92A 1w5uA-5ur2A:
undetectable
1w5uB-5ur2A:
undetectable		 1w5uA-5ur2A:
2.82
1w5uB-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.76A 1w5uA-4nmeA:
undetectable
1w5uB-4nmeA:
undetectable		 1w5uA-4nmeA:
2.23
1w5uB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 TRP A 305
ALA A 272
VAL A 321
 P5F  A1001 (-3.7A)
None
None
 0.84A 1w5uA-5ur2A:
undetectable
1w5uB-5ur2A:
undetectable		 1w5uA-5ur2A:
2.82
1w5uB-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.85A 2izqA-4nmeA:
undetectable
2izqB-4nmeA:
undetectable		 2izqA-4nmeA:
2.23
2izqB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 ALA A 272
VAL A 321
TRP A 305
 None
None
P5F  A1001 (-3.7A)
 0.93A 2izqA-5ur2A:
undetectable
2izqB-5ur2A:
undetectable		 2izqA-5ur2A:
2.82
2izqB-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.87A 2izqC-4nmeA:
undetectable
2izqD-4nmeA:
undetectable		 2izqC-4nmeA:
2.23
2izqD-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 TRP A 305
ALA A 272
VAL A 321
 P5F  A1001 (-3.7A)
None
None
 0.94A 2izqC-5ur2A:
undetectable
2izqD-5ur2A:
undetectable		 2izqC-5ur2A:
2.82
2izqD-5ur2A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 SER A 247
ASP A 244
ASP A 775
TYR A 160
 None
P5F  A1101 (-3.2A)
None
None
 1.18A 3havA-4nmeA:
undetectable		 3havA-4nmeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.98A 3l8lA-4nmeA:
undetectable
3l8lB-4nmeA:
undetectable		 3l8lA-4nmeA:
2.23
3l8lB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.84A 3l8lC-4nmeA:
undetectable
3l8lD-4nmeA:
undetectable		 3l8lC-4nmeA:
2.23
3l8lD-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5ur2 BIFUNCTIONAL PROTEIN
PUTA
(Bdellovibrio
bacteriovorus) 		3 / 3 TRP A 305
ALA A 272
VAL A 321
 P5F  A1001 (-3.7A)
None
None
 0.90A 3l8lC-5ur2A:
undetectable
3l8lD-5ur2A:
undetectable		 3l8lC-5ur2A:
2.82
3l8lD-5ur2A:
2.82