SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P4G'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A27_A_ESTA350_1 (17-BETA-HYDROXYSTERO ID-DEHYDROGENASE)	3ci6	PHOSPHOENOLPYRUVATE- PROTEIN PHOSPHOTRANSFERASE (Acinetobacter sp. ADP1)	5 / 12	VAL A 117 GLY A 116 LEU A 115 ASN A 90 MET A 37	None None None None P4G A 169 ( 4.3A)	1.25A	1a27A-3ci6A: undetectable	1a27A-3ci6A: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB4_0 (FERROCHELATASE)	5oex	- (-)	4 / 6	ARG A 237 PRO A 414 GLY A 322 TRP A 324	P4G A 605 (-3.9A) None None None	1.24A	3aqiB-5oexA: undetectable	3aqiB-5oexA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ARR_A_PNXA607_1 (CHITINASE A)	3wmr	PROLINE IMINOPEPTIDASE (Streptomyces halstedii)	4 / 7	TRP A 111 VAL A 210 LEU A 86 TRP A 229	None None None P4G A 402 (-4.4A)	1.10A	3arrA-3wmrA: undetectable	3arrA-3wmrA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGH_C_SAMC401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	5yqw	PEPTIDE ABC TRANSPORTER, PERIPLASMIC PEPTIDE-BINDING PROTEIN (Vibrio harveyi)	5 / 11	SER A 125 GLY A 104 ASP A 101 VAL A 94 MET A 434	P4G A 602 (-3.5A) P4G A 602 ( 4.2A) None None None	1.48A	4pghC-5yqwA: undetectable	4pghC-5yqwA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYN_B_RTLB201_0 (RETINOL-BINDING PROTEIN 2)	6eq8	PERIPLASMIC ALPHA-GALACTOSIDE-BI NDING PROTEIN (Agrobacterium tumefaciens)	5 / 12	ILE D 113 THR D 88 ARG D 646 LEU D 661 LEU D 285	None None None P4G D 713 ( 3.6A) None	1.29A	4qynB-6eq8D: undetectable	4qynB-6eq8D: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K9D_A_CE9A402_0 (DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL)	3ci6	PHOSPHOENOLPYRUVATE- PROTEIN PHOSPHOTRANSFERASE (Acinetobacter sp. ADP1)	5 / 12	ALA A 34 ALA A 36 THR A 8 PHE A 146 LEU A 150	None P4G A 169 ( 4.3A) P4G A 169 (-3.6A) P4G A 169 ( 4.2A) None	1.18A	5k9dA-3ci6A: undetectable	5k9dA-3ci6A: 19.78

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A27_A_ESTA350_1","17-BETA-HYDROXYSTEROID-DEHYDROGENASE","3ci6","PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE","Acinetobacter sp. ADP1",5,"VAL A 117;GLY A 116;LEU A 115;ASN A  90;MET A  37","None;None;None;None;P4G A 169 ( 4.3A)","1.25A","1a27A-3ci6A:undetectable",null],["3AQI_B_CHDB4_0","FERROCHELATASE","5oex","-","-",4,"ARG A 237;PRO A 414;GLY A 322;TRP A 324","P4G A 605 (-3.9A);None;None;None","1.24A","3aqiB-5oexA:undetectable","1a27A-3ci6A:24.07"],["3ARR_A_PNXA607_1","CHITINASE A","3wmr","PROLINE IMINOPEPTIDASE","Streptomyces halstedii",4,"TRP A 111;VAL A 210;LEU A  86;TRP A 229","None;None;None;P4G A 402 (-4.4A)","1.10A","3arrA-3wmrA:undetectable","3aqiB-5oexA:undetectable"],["4PGH_C_SAMC401_0","CAFFEIC ACID O-METHYLTRANSFERASE","5yqw","PEPTIDE ABC TRANSPORTER, PERIPLASMIC PEPTIDE-BINDING PROTEIN","Vibrio harveyi",5,"SER A 125;GLY A 104;ASP A 101;VAL A  94;MET A 434","P4G A 602 (-3.5A);P4G A 602 ( 4.2A);None;None;None","1.48A","4pghC-5yqwA:undetectable","3arrA-3wmrA:19.03"],["4QYN_B_RTLB201_0","RETINOL-BINDING PROTEIN 2","6eq8","PERIPLASMIC ALPHA-GALACTOSIDE-BINDING PROTEIN","Agrobacterium tumefaciens",5,"ILE D 113;THR D  88;ARG D 646;LEU D 661;LEU D 285","None;None;None;P4G D 713 ( 3.6A);None","1.29A","4qynB-6eq8D:undetectable","4pghC-5yqwA:undetectable"],["5K9D_A_CE9A402_0","DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL","3ci6","PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE","Acinetobacter sp. ADP1",5,"ALA A  34;ALA A  36;THR A   8;PHE A 146;LEU A 150","None;P4G A 169 ( 4.3A);P4G A 169 (-3.6A);P4G A 169 ( 4.2A);None","1.18A","5k9dA-3ci6A:undetectable","4qynB-6eq8D:undetectable"]]