SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P3T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 6 ALA A 367
TYR A 368
ASP A 314
TYR A 240
 None
P3T  A 501 (-3.5A)
P3T  A 501 (-3.7A)
None
 1.06A 2pncB-2pljA:
undetectable		 2pncB-2pljA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 8 SER A 197
ARG A 273
THR A 369
THR A 372
 P3T  A 501 (-2.5A)
P3T  A 501 (-4.8A)
None
None
 0.89A 3bpxA-2pljA:
undetectable
3bpxB-2pljA:
undetectable		 3bpxA-2pljA:
17.87
3bpxB-2pljA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 9 LYS A  66
HIS A 194
GLY A 196
SER A 197
TYR A 368
 P3T  A 501 (-1.2A)
P3T  A 501 (-3.8A)
None
P3T  A 501 (-2.5A)
P3T  A 501 (-3.5A)
 0.49A 3n2oA-2pljA:
25.4
3n2oB-2pljA:
10.3		 3n2oA-2pljA:
22.63
3n2oB-2pljA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 10 LYS A  66
HIS A 194
GLY A 196
ARG A 273
TYR A 368
 P3T  A 501 (-1.2A)
P3T  A 501 (-3.8A)
None
P3T  A 501 (-4.8A)
P3T  A 501 (-3.5A)
 0.48A 3n2oC-2pljA:
25.5
3n2oD-2pljA:
25.5		 3n2oC-2pljA:
22.63
3n2oD-2pljA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 LYS A 166
ARG A 151
LYS A 138
 None
P3T  A 501 (-3.9A)
None
 1.43A 3okxA-2pljA:
undetectable		 3okxA-2pljA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 SER A 370
GLU A  91
GLU A 270
 None
None
P3T  A 501 (-3.7A)
 0.76A 4ymgB-2pljA:
undetectable		 4ymgB-2pljA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 5 THR A 108
HIS A 107
ALA A  87
ASP A  85
 None
None
None
P3T  A 501 ( 4.6A)
 1.16A 5mfxA-2pljA:
undetectable		 5mfxA-2pljA:
24.25