SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P3S'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZT7_A_GLYA1300_0 (GLYCYL-TRNA SYNTHETASE)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	4 / 7	ARG A 316 GLU A 129 TYR A 158 GLU A 199	ADP A6001 (-2.8A) MN A1002 ( 2.0A) P3S A5001 ( 4.9A) MN A1001 ( 2.5A)	1.17A	2zt7A-2d3aA: undetectable	2zt7A-2d3aA: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BUP_B_SAMB500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	3 / 3	HIS A 249 GLU A 192 ASN A 244	MN A1002 ( 3.5A) MN A1003 ( 3.0A) P3S A5001 ( 4.7A)	1.04A	4bupB-2d3aA: undetectable	4bupB-2d3aA: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0V_D_MIXD101_1 (DNA TOPOISOMERASE 2-BETA)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	4 / 6	ARG A 316 GLY A 312 ASN A 244 GLU A 297	ADP A6001 (-2.8A) None P3S A5001 ( 4.7A) P3S A5001 (-3.4A)	1.17A	4g0vB-2d3aA: 1.9	4g0vB-2d3aA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M6K_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	5 / 12	ILE A 266 ARG A 332 PHE A 329 ILE A 347 LEU A 273	None P3S A5001 ( 3.1A) None None None	1.03A	4m6kA-2d3aA: undetectable	4m6kA-2d3aA: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R87_H_SPMH202_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	3o6x	GLUTAMINE SYNTHETASE (Bacteroides fragilis)	4 / 6	GLU A 215 TYR A 218 GLU A 217 GLU A 286	ADP A4001 (-2.4A) None P3S A3001 ( 3.2A) MG A2001 ( 2.8A)	1.33A	4r87H-3o6xA: undetectable	4r87H-3o6xA: 13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWK_F_EVPF102_1 (DNA TOPOISOMERASE 2-ALPHA)	3o6x	GLUTAMINE SYNTHETASE (Bacteroides fragilis)	4 / 5	GLY A 394 ARG A 398 MET A 312 MET A 315	None P3S A3001 (-3.8A) None None	1.18A	5gwkA-3o6xA: undetectable	5gwkA-3o6xA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_D_CCSD14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2 PROGRAMMED CELL DEATH 1 LIGAND 1)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	5 / 12	LEU A 292 SER A 336 GLY A 247 GLY A 245 ARG A 290	None None P3S A5001 ( 4.1A) P3S A5001 (-4.3A) None	1.32A	5o4yD-2d3aA: undetectable 5o4yE-2d3aA: undetectable	5o4yD-2d3aA: 2.82 5o4yE-2d3aA: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_A_SAMA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	3 / 3	HIS A 249 GLU A 192 ASN A 244	MN A1002 ( 3.5A) MN A1003 ( 3.0A) P3S A5001 ( 4.7A)	1.01A	5wbvA-2d3aA: undetectable	5wbvA-2d3aA: 18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_B_SAMB402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	3 / 3	HIS A 249 GLU A 192 ASN A 244	MN A1002 ( 3.5A) MN A1003 ( 3.0A) P3S A5001 ( 4.7A)	1.01A	5wbvB-2d3aA: undetectable	5wbvB-2d3aA: 18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	2d3a	GLUTAMINE SYNTHETASE (Zea mays)	5 / 10	GLU A 129 HIS A 249 ALA A 309 GLU A 297 ARG A 332	MN A1002 ( 2.0A) MN A1002 ( 3.5A) None P3S A5001 (-3.4A) P3S A5001 ( 3.1A)	1.17A	6bniA-2d3aA: undetectable	6bniA-2d3aA: 12.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZT7_A_GLYA1300_0","GLYCYL-TRNA SYNTHETASE","2d3a","GLUTAMINE SYNTHETASE","Zea mays",4,"ARG A 316;GLU A 129;TYR A 158;GLU A 199","ADP A6001 (-2.8A); MN A1002 ( 2.0A);P3S A5001 ( 4.9A); MN A1001 ( 2.5A)","1.17A","2zt7A-2d3aA:undetectable",null],["4BUP_B_SAMB500_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","2d3a","GLUTAMINE SYNTHETASE","Zea mays",3,"HIS A 249;GLU A 192;ASN A 244"," MN A1002 ( 3.5A); MN A1003 ( 3.0A);P3S A5001 ( 4.7A)","1.04A","4bupB-2d3aA:undetectable","2zt7A-2d3aA:20.09"],["4G0V_D_MIXD101_1","DNA TOPOISOMERASE 2-BETA","2d3a","GLUTAMINE SYNTHETASE","Zea mays",4,"ARG A 316;GLY A 312;ASN A 244;GLU A 297","ADP A6001 (-2.8A);None;P3S A5001 ( 4.7A);P3S A5001 (-3.4A)","1.17A","4g0vB-2d3aA:1.9","4bupB-2d3aA:19.70"],["4M6K_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2d3a","GLUTAMINE SYNTHETASE","Zea mays",5,"ILE A 266;ARG A 332;PHE A 329;ILE A 347;LEU A 273","None;P3S A5001 ( 3.1A);None;None;None","1.03A","4m6kA-2d3aA:undetectable","4g0vB-2d3aA:17.99"],["4R87_H_SPMH202_1","SPERMIDINE N1-ACETYLTRANSFERASE","3o6x","GLUTAMINE SYNTHETASE","Bacteroides fragilis",4,"GLU A 215;TYR A 218;GLU A 217;GLU A 286","ADP A4001 (-2.4A);None;P3S A3001 ( 3.2A); MG A2001 ( 2.8A)","1.33A","4r87H-3o6xA:undetectable","4m6kA-2d3aA:19.15"],["5GWK_F_EVPF102_1","DNA TOPOISOMERASE 2-ALPHA","3o6x","GLUTAMINE SYNTHETASE","Bacteroides fragilis",4,"GLY A 394;ARG A 398;MET A 312;MET A 315","None;P3S A3001 (-3.8A);None;None","1.18A","5gwkA-3o6xA:undetectable","4r87H-3o6xA:13.79"],["5O4Y_D_CCSD14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1","2d3a","GLUTAMINE SYNTHETASE","Zea mays",5,"LEU A 292;SER A 336;GLY A 247;GLY A 245;ARG A 290","None;None;P3S A5001 ( 4.1A);P3S A5001 (-4.3A);None","1.32A","5o4yD-2d3aA:undetectable;5o4yE-2d3aA:undetectable","5gwkA-3o6xA:22.85"],["5WBV_A_SAMA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","2d3a","GLUTAMINE SYNTHETASE","Zea mays",3,"HIS A 249;GLU A 192;ASN A 244"," MN A1002 ( 3.5A); MN A1003 ( 3.0A);P3S A5001 ( 4.7A)","1.01A","5wbvA-2d3aA:undetectable","5o4yD-2d3aA:2.82;5o4yE-2d3aA:16.72"],["5WBV_B_SAMB402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","2d3a","GLUTAMINE SYNTHETASE","Zea mays",3,"HIS A 249;GLU A 192;ASN A 244"," MN A1002 ( 3.5A); MN A1003 ( 3.0A);P3S A5001 ( 4.7A)","1.01A","5wbvB-2d3aA:undetectable","5wbvA-2d3aA:18.98"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","2d3a","GLUTAMINE SYNTHETASE","Zea mays",5,"GLU A 129;HIS A 249;ALA A 309;GLU A 297;ARG A 332"," MN A1002 ( 2.0A); MN A1002 ( 3.5A);None;P3S A5001 (-3.4A);P3S A5001 ( 3.1A)","1.17A","6bniA-2d3aA:undetectable","5wbvB-2d3aA:18.98"]]