SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P3G'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	4 / 8	SER A 36 HIS A 204 LYS A 227 ARG A 375	P3G A 701 ( 2.9A) PLP A1227 ( 4.0A) PLP A1227 (-1.3A) CL A 601 (-3.1A)	0.88A	1eqbA-1qz9A: 25.6 1eqbB-1qz9A: 26.9	1eqbA-1qz9A: 24.63 1eqbB-1qz9A: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	4 / 8	SER A 36 HIS A 204 LYS A 227 ARG A 375	P3G A 701 ( 2.9A) PLP A1227 ( 4.0A) PLP A1227 (-1.3A) CL A 601 (-3.1A)	0.89A	1eqbA-1qz9A: 25.6 1eqbB-1qz9A: 26.9	1eqbA-1qz9A: 24.63 1eqbB-1qz9A: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	4 / 8	SER A 36 HIS A 204 LYS A 227 ARG A 375	P3G A 701 ( 2.9A) PLP A1227 ( 4.0A) PLP A1227 (-1.3A) CL A 601 (-3.1A)	0.88A	1eqbC-1qz9A: 26.8 1eqbD-1qz9A: 26.8	1eqbC-1qz9A: 24.63 1eqbD-1qz9A: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	4 / 8	SER A 36 HIS A 204 LYS A 227 ARG A 375	P3G A 701 ( 2.9A) PLP A1227 ( 4.0A) PLP A1227 (-1.3A) CL A 601 (-3.1A)	0.89A	1eqbC-1qz9A: 26.8 1eqbD-1qz9A: 26.8	1eqbC-1qz9A: 24.63 1eqbD-1qz9A: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	4 / 7	SER A 36 HIS A 204 LYS A 227 ARG A 375	P3G A 701 ( 2.9A) PLP A1227 ( 4.0A) PLP A1227 (-1.3A) CL A 601 (-3.1A)	0.85A	2vmyA-1qz9A: 27.2 2vmyB-1qz9A: 27.2	2vmyA-1qz9A: 23.66 2vmyB-1qz9A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_B_LYAB514_2 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	1qz9	KYNURENINASE (Pseudomonas fluorescens)	3 / 3	ARG A 369 THR A 124 THR A 97	P3G A 701 (-2.5A) None PLP A1227 (-3.8A)	0.76A	3k2hB-1qz9A: undetectable	3k2hB-1qz9A: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QB9_D_PARD500_1 (ENHANCED INTRACELLULAR SURVIVAL PROTEIN)	4ru0	PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER, PERIPLASMIC BRANCHED-CHAIN AMINO ACID-BINDING PROTEIN (Pseudomonas protegens)	4 / 8	SER A 269 GLU A 157 ASP A 264 TYR A 133	None None None P3G A 501 ( 3.9A)	1.17A	4qb9D-4ru0A: undetectable	4qb9D-4ru0A: 24.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",4,"SER A  36;HIS A 204;LYS A 227;ARG A 375","P3G A 701 ( 2.9A);PLP A1227 ( 4.0A);PLP A1227 (-1.3A); CL A 601 (-3.1A)","0.88A","1eqbA-1qz9A:25.6;1eqbB-1qz9A:26.9",null],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",4,"SER A  36;HIS A 204;LYS A 227;ARG A 375","P3G A 701 ( 2.9A);PLP A1227 ( 4.0A);PLP A1227 (-1.3A); CL A 601 (-3.1A)","0.89A","1eqbA-1qz9A:25.6;1eqbB-1qz9A:26.9","1eqbA-1qz9A:24.63;1eqbB-1qz9A:24.63"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",4,"SER A  36;HIS A 204;LYS A 227;ARG A 375","P3G A 701 ( 2.9A);PLP A1227 ( 4.0A);PLP A1227 (-1.3A); CL A 601 (-3.1A)","0.88A","1eqbC-1qz9A:26.8;1eqbD-1qz9A:26.8","1eqbA-1qz9A:24.63;1eqbB-1qz9A:24.63"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",4,"SER A  36;HIS A 204;LYS A 227;ARG A 375","P3G A 701 ( 2.9A);PLP A1227 ( 4.0A);PLP A1227 (-1.3A); CL A 601 (-3.1A)","0.89A","1eqbC-1qz9A:26.8;1eqbD-1qz9A:26.8","1eqbC-1qz9A:24.63;1eqbD-1qz9A:24.63"],["2VMY_A_GLYA502_0","SERINE HYDROXYMETHYLTRANSFERASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",4,"SER A  36;HIS A 204;LYS A 227;ARG A 375","P3G A 701 ( 2.9A);PLP A1227 ( 4.0A);PLP A1227 (-1.3A); CL A 601 (-3.1A)","0.85A","2vmyA-1qz9A:27.2;2vmyB-1qz9A:27.2","1eqbC-1qz9A:24.63;1eqbD-1qz9A:24.63"],["3K2H_B_LYAB514_2","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","1qz9","KYNURENINASE","Pseudomonas fluorescens",3,"ARG A 369;THR A 124;THR A  97","P3G A 701 (-2.5A);None;PLP A1227 (-3.8A)","0.76A","3k2hB-1qz9A:undetectable","2vmyA-1qz9A:23.66;2vmyB-1qz9A:23.66"],["4QB9_D_PARD500_1","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","4ru0","PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER, PERIPLASMIC BRANCHED-CHAIN AMINO ACID-BINDING PROTEIN","Pseudomonas protegens",4,"SER A 269;GLU A 157;ASP A 264;TYR A 133","None;None;None;P3G A 501 ( 3.9A)","1.17A","4qb9D-4ru0A:undetectable","3k2hB-1qz9A:21.39"]]