SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P30'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
ASN A 816
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-4.6A)
 0.64A 1fmoE-4rt7A:
15.4		 1fmoE-4rt7A:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.73A 1iepA-4rt7A:
29.3		 1iepA-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.61A 1iepA-4xufA:
34.0		 1iepA-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
 0.74A 1iepB-4rt7A:
29.0		 1iepB-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.70A 1m17A-4xufA:
29.8		 1m17A-4xufA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.68A 1muoA-4rt7A:
8.1		 1muoA-4rt7A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.81A 1muoA-4xufA:
23.5		 1muoA-4xufA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
 0.61A 1opjA-4rt7A:
28.0		 1opjA-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.53A 1opjA-4xufA:
33.5		 1opjA-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.46A 1opjA-4xufA:
33.5		 1opjA-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
None
 0.71A 1opjB-4rt7A:
27.9		 1opjB-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
None
 0.71A 1opjB-4xufA:
27.5		 1opjB-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.55A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.71A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 CYH A 694
CYH A 807
ARG A 810
CYH A 828
 None
None
None
P30  A1001 (-4.1A)
 1.04A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 TYR A 693
CYH A 694
CYH A 807
CYH A 828
 P30  A1001 (-4.1A)
None
None
P30  A1001 (-4.1A)
 0.42A 1t46A-4rt7A:
34.5		 1t46A-4rt7A:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 TYR A 693
CYH A 694
ARG A 810
CYH A 828
 P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.8A)
 1.04A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 TYR A 693
CYH A 694
CYH A 807
CYH A 828
 P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.8A)
 0.38A 1t46A-4xufA:
39.3		 1t46A-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.36A 1uwhA-4rt7A:
18.9		 1uwhA-4rt7A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.48A 1uwhA-4xufA:
28.6		 1uwhA-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.45A 1uwhB-4rt7A:
18.7		 1uwhB-4rt7A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.59A 1uwhB-4xufA:
28.4		 1uwhB-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.46A 1uwjA-4rt7A:
10.2		 1uwjA-4rt7A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.46A 1uwjA-4xufA:
27.5		 1uwjA-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.46A 1uwjB-4rt7A:
10.3		 1uwjB-4rt7A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.45A 1uwjB-4xufA:
27.4		 1uwjB-4xufA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.42A 1xbbA-4rt7A:
31.5		 1xbbA-4rt7A:
28.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.40A 1xbbA-4xufA:
30.2		 1xbbA-4xufA:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
None
P30  A1001 (-4.6A)
None
 0.89A 2eufB-4rt7A:
18.8		 2eufB-4rt7A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
 None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
None
P30  A1001 (-4.6A)
 0.71A 2eufB-4rt7A:
18.8		 2eufB-4rt7A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.3A)
None
None
P30  A1001 (-4.3A)
 0.78A 2eufB-4xufA:
17.4		 2eufB-4xufA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.77A 2gqgA-4xufA:
30.5		 2gqgA-4xufA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
MET A 665
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.77A 2gqgA-4xufA:
30.5		 2gqgA-4xufA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.57A 2gqgB-4rt7A:
31.7		 2gqgB-4rt7A:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.49A 2gqgB-4xufA:
30.9		 2gqgB-4xufA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.48A 2gqgB-4xufA:
30.9		 2gqgB-4xufA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.65A 2hyyA-4rt7A:
29.2		 2hyyA-4rt7A:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.60A 2hyyA-4xufA:
34.0		 2hyyA-4xufA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.64A 2hyyB-4rt7A:
29.0		 2hyyB-4rt7A:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.59A 2hyyB-4xufA:
28.5		 2hyyB-4xufA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.63A 2hyyC-4rt7A:
29.0		 2hyyC-4rt7A:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.51A 2hyyC-4xufA:
33.9		 2hyyC-4xufA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 665
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.87A 2hyyD-4xufA:
34.4		 2hyyD-4xufA:
38.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 2itoA-4rt7A:
24.7		 2itoA-4rt7A:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
 0.73A 2itoA-4rt7A:
24.7		 2itoA-4rt7A:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 2itoA-4xufA:
24.1		 2itoA-4xufA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.83A 2ityA-4rt7A:
26.2		 2ityA-4rt7A:
28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 2ityA-4xufA:
23.6		 2ityA-4xufA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
 0.46A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
LYS A 644
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.45A 2ivuA-4rt7A:
26.2		 2ivuA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
GLY A 617
VAL A 624
LEU A 689
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.36A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
 0.66A 2ivuA-4xufA:
31.5		 2ivuA-4xufA:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.65A 2oiqA-4rt7A:
25.5		 2oiqA-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.65A 2oiqA-4xufA:
25.1		 2oiqA-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
MET A 665
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.85A 2oiqA-4xufA:
25.1		 2oiqA-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
 0.86A 2pl0A-4xufA:
25.3		 2pl0A-4xufA:
37.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ILE A 867
LEU A 668
PHE A 801
ILE A 827
ASN A 673
 None
None
None
P30  A1001 ( 4.8A)
None
 0.97A 2w3bB-4rt7A:
undetectable		 2w3bB-4rt7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ILE A 867
LEU A 668
PHE A 801
ILE A 827
ASN A 673
 None
None
None
P30  A1001 (-4.7A)
None
 1.14A 2w3bB-4xufA:
undetectable		 2w3bB-4xufA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.75A 2zvaA-4xufA:
31.3		 2zvaA-4xufA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
ALA A 642
LYS A 644
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.72A 3aoxA-4rt7A:
24.6		 3aoxA-4rt7A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
ALA A 642
LYS A 644
VAL A 675
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.47A 3c7qA-4rt7A:
30.3		 3c7qA-4rt7A:
45.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.55A 3c7qA-4rt7A:
30.3		 3c7qA-4rt7A:
45.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
ALA A 642
LYS A 644
VAL A 675
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.81A 3c7qA-4xufA:
34.1		 3c7qA-4xufA:
52.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
 0.77A 3c7qA-4xufA:
34.1		 3c7qA-4xufA:
52.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 10 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
None
 0.99A 3cs9A-4rt7A:
29.4		 3cs9A-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 10 LEU A 616
VAL A 624
LYS A 644
VAL A 675
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
None
 0.71A 3cs9A-4xufA:
34.0		 3cs9A-4xufA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
GLY A 697
HIS A 809
LEU A 818
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
 0.34A 3cs9A-4rt7A:
29.4		 3cs9A-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
GLY A 697
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
 0.84A 3cs9B-4rt7A:
27.3		 3cs9B-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
GLY A 697
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.79A 3cs9B-4xufA:
31.6		 3cs9B-4xufA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
VAL A 624
LYS A 644
VAL A 675
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.80A 3cs9B-4rt7A:
27.3		 3cs9B-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
VAL A 624
LYS A 644
VAL A 675
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-4.3A)
 0.61A 3cs9B-4xufA:
31.6		 3cs9B-4xufA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
VAL A 624
LYS A 644
VAL A 675
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.9A)
 1.19A 3cs9C-4rt7A:
26.5		 3cs9C-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.97A 3cs9D-4rt7A:
29.2		 3cs9D-4rt7A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 LEU A 616
VAL A 624
LYS A 644
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.3A)
None
 0.81A 3cs9D-4xufA:
32.3		 3cs9D-4xufA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ILE A 867
MET A 665
VAL A 675
LEU A 818
ILE A 674
 None
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.6A)
None
 1.32A 3em0B-4rt7A:
undetectable		 3em0B-4rt7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.49A 3fupB-4rt7A:
22.9		 3fupB-4rt7A:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 11 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
CYH A 694
GLY A 697
ALA A 833
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
 0.76A 3g0eA-4rt7A:
30.9		 3g0eA-4rt7A:
48.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 11 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.58A 3g0eA-4rt7A:
30.9		 3g0eA-4rt7A:
48.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 11 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.54A 3g0eA-4xufA:
36.7		 3g0eA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 11 VAL A 624
ALA A 642
VAL A 675
TYR A 693
CYH A 694
GLY A 697
LEU A 818
CYH A 828
ALA A 833
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.4A)
 0.89A 3g0eA-4xufA:
36.7		 3g0eA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 11 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.70A 3g0fA-4rt7A:
39.9		 3g0fA-4rt7A:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 11 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.57A 3g0fA-4xufA:
39.2		 3g0fA-4xufA:
60.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 11 VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.72A 3g0fA-4xufA:
39.2		 3g0fA-4xufA:
60.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 10 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.61A 3g0fB-4rt7A:
40.7		 3g0fB-4rt7A:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 10 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.70A 3g0fB-4xufA:
39.9		 3g0fB-4xufA:
60.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.59A 3g5dA-4rt7A:
24.6		 3g5dA-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.53A 3g5dA-4xufA:
24.3		 3g5dA-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.74A 3g5dB-4rt7A:
24.7		 3g5dB-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.68A 3g5dB-4xufA:
24.3		 3g5dB-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.79A 3g5dB-4xufA:
24.3		 3g5dB-4xufA:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
 0.88A 3gp0A-4rt7A:
22.6		 3gp0A-4rt7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.80A 3gp0A-4xufA:
22.0		 3gp0A-4xufA:
24.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
 0.60A 3gvuA-4rt7A:
28.6		 3gvuA-4rt7A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.54A 3gvuA-4xufA:
33.1		 3gvuA-4xufA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.42A 3ik3A-4rt7A:
28.1		 3ik3A-4rt7A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.75A 3ik3A-4xufA:
32.6		 3ik3A-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 GLU A 661
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.57A 3ik3A-4xufA:
32.6		 3ik3A-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.42A 3ik3B-4rt7A:
35.0		 3ik3B-4rt7A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.48A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.65A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 GLU A 661
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.57A 3ik3B-4xufA:
33.2		 3ik3B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.75A 3k54A-4rt7A:
26.4		 3k54A-4rt7A:
31.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.66A 3k54A-4xufA:
30.0		 3k54A-4xufA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.61A 3k5vA-4rt7A:
34.7		 3k5vA-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.57A 3k5vA-4xufA:
33.5		 3k5vA-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.63A 3k5vB-4rt7A:
34.5		 3k5vB-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.56A 3k5vB-4xufA:
33.5		 3k5vB-4xufA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
 0.61A 3lxkA-4rt7A:
24.5		 3lxkA-4rt7A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.67A 3lxkA-4rt7A:
24.5		 3lxkA-4rt7A:
27.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.82A 3lxkA-4xufA:
28.6		 3lxkA-4xufA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.48A 3lxnA-4rt7A:
22.4		 3lxnA-4rt7A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.62A 3lxnA-4xufA:
28.2		 3lxnA-4xufA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.6A)
None
 0.65A 3ms9A-4rt7A:
29.1		 3ms9A-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
None
 0.66A 3ms9A-4xufA:
28.5		 3ms9A-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.64A 3ms9B-4rt7A:
29.4		 3ms9B-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.67A 3ms9B-4xufA:
28.6		 3ms9B-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.6A)
None
 0.66A 3mssA-4rt7A:
29.2		 3mssA-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
None
 0.71A 3mssA-4xufA:
28.5		 3mssA-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.68A 3mssB-4rt7A:
29.2		 3mssB-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.58A 3mssB-4xufA:
33.5		 3mssB-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.6A)
None
 0.68A 3mssC-4rt7A:
29.1		 3mssC-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
None
 0.71A 3mssC-4xufA:
28.5		 3mssC-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.60A 3mssD-4rt7A:
29.2		 3mssD-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.70A 3mssD-4xufA:
33.4		 3mssD-4xufA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.52A 3octA-4rt7A:
31.2		 3octA-4rt7A:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
LYS A 644
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.86A 3octA-4rt7A:
31.2		 3octA-4rt7A:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.71A 3octA-4xufA:
30.1		 3octA-4xufA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.52A 3oezA-4rt7A:
25.2		 3oezA-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.52A 3oezA-4xufA:
24.7		 3oezA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.78A 3oezA-4xufA:
24.7		 3oezA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 1.19A 3oezB-4rt7A:
25.3		 3oezB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
 0.77A 3oezB-4xufA:
24.7		 3oezB-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
VAL A 675
GLY A 697
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
None
 0.54A 3oxzA-4rt7A:
27.3		 3oxzA-4rt7A:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
VAL A 675
GLY A 697
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
 0.82A 3oxzA-4rt7A:
27.3		 3oxzA-4rt7A:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
GLY A 697
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.74A 3oxzA-4xufA:
31.7		 3oxzA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
VAL A 675
GLY A 697
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
 0.54A 3oxzA-4xufA:
31.7		 3oxzA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
MET A 665
VAL A 675
GLY A 697
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
 0.91A 3oxzA-4xufA:
31.7		 3oxzA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
 0.63A 3pyyB-4rt7A:
27.0		 3pyyB-4rt7A:
33.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.57A 3pyyB-4xufA:
31.2		 3pyyB-4xufA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.83A 3qlgA-4rt7A:
24.8		 3qlgA-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.65A 3qlgA-4xufA:
24.4		 3qlgA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.75A 3qlgA-4xufA:
24.4		 3qlgA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.69A 3qlgB-4rt7A:
24.7		 3qlgB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.59A 3qlgB-4xufA:
24.1		 3qlgB-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.76A 3qlgB-4xufA:
24.1		 3qlgB-4xufA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
PHE A 691
TYR A 693
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.7A)
P30  A1001 (-4.1A)
None
P30  A1001 ( 4.3A)
 0.70A 3rgfA-4rt7A:
21.2		 3rgfA-4rt7A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
PHE A 691
TYR A 693
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.3A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.4A)
 0.74A 3rgfA-4xufA:
20.9		 3rgfA-4xufA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.38A 3sxrA-4rt7A:
30.2		 3sxrA-4rt7A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.52A 3sxrA-4xufA:
29.7		 3sxrA-4xufA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.38A 3sxrB-4rt7A:
24.7		 3sxrB-4rt7A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.51A 3sxrB-4xufA:
29.3		 3sxrB-4xufA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.74A 3sxrB-4xufA:
29.3		 3sxrB-4xufA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
P30  A1001 (-4.6A)
 0.65A 3ti1A-4rt7A:
21.8		 3ti1A-4rt7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 P30  A1001 (-3.5A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.3A)
 0.87A 3ti1A-4xufA:
21.1		 3ti1A-4xufA:
26.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
MET A 665
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.79A 3ue4B-4xufA:
31.4		 3ue4B-4xufA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
MET A 665
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 3ue4B-4xufA:
31.4		 3ue4B-4xufA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.96A 3ug2A-4rt7A:
25.6		 3ug2A-4rt7A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.85A 3ug2A-4xufA:
23.1		 3ug2A-4xufA:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
GLY A 617
ALA A 642
GLU A 661
CYH A 694
CYH A 828
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
 0.78A 3wzdA-4rt7A:
34.8		 3wzdA-4rt7A:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
CYH A 828
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
 0.46A 3wzdA-4rt7A:
34.8		 3wzdA-4rt7A:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
VAL A 624
ALA A 642
CYH A 694
GLY A 697
CYH A 828
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.8A)
 0.45A 3wzdA-4xufA:
32.9		 3wzdA-4xufA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
CYH A 828
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.8A)
 0.51A 3wzdA-4xufA:
32.9		 3wzdA-4xufA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
 0.29A 3wzeA-4rt7A:
32.1		 3wzeA-4rt7A:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.4A)
 0.55A 3wzeA-4xufA:
39.2		 3wzeA-4xufA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 8 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
ASP A 829
PHE A 830
 None
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.9A)
 0.42A 3wzeA-4rt7A:
32.1		 3wzeA-4rt7A:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 8 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
ASP A 829
PHE A 830
 None
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
P30  A1001 (-4.8A)
None
P30  A1001 ( 4.1A)
 0.34A 3wzeA-4xufA:
39.2		 3wzeA-4xufA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 616
ALA A 642
GLY A 697
ASP A 698
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
 0.45A 3zbfA-4xufA:
30.5		 3zbfA-4xufA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 3zosA-4rt7A:
27.4		 3zosA-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.10A 3zosA-4xufA:
33.1		 3zosA-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.76A 3zosA-4xufA:
33.1		 3zosA-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 ALA A 642
LYS A 644
GLU A 661
LEU A 802
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 3zosB-4rt7A:
27.5		 3zosB-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.61A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 ALA A 642
LYS A 644
GLU A 661
HIS A 809
ARG A 810
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.10A 3zosB-4xufA:
26.4		 3zosB-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.39A 4ag8A-4rt7A:
34.5		 4ag8A-4rt7A:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		10 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.68A 4ag8A-4xufA:
39.4		 4ag8A-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.30A 4agcA-4rt7A:
31.3		 4agcA-4rt7A:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.59A 4agcA-4xufA:
39.1		 4agcA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 818
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.72A 4agcA-4xufA:
39.1		 4agcA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 11 LEU A 616
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.36A 4agdA-4rt7A:
32.8		 4agdA-4rt7A:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 11 LYS A 644
VAL A 675
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
 0.66A 4agdA-4rt7A:
32.8		 4agdA-4rt7A:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 11 LEU A 616
ALA A 642
VAL A 675
CYH A 694
GLY A 697
LEU A 818
CYH A 828
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
 0.45A 4agdA-4xufA:
29.0		 4agdA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-3.9A)
 0.38A 4asdA-4rt7A:
32.2		 4asdA-4rt7A:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 802
HIS A 809
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.4A)
P30  A1001 ( 4.1A)
 0.57A 4asdA-4xufA:
39.0		 4asdA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
HIS A 809
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.1A)
 0.69A 4asdA-4xufA:
39.0		 4asdA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
 None
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.1A)
 0.36A 4asdA-4rt7A:
32.2		 4asdA-4rt7A:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
 None
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
P30  A1001 (-4.8A)
 0.24A 4asdA-4xufA:
39.0		 4asdA-4xufA:
51.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 0.96A 4bkjA-4rt7A:
29.0		 4bkjA-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
 1.04A 4bkjA-4xufA:
25.3		 4bkjA-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.99A 4bkjB-4rt7A:
29.0		 4bkjB-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.03A 4bkjB-4xufA:
25.1		 4bkjB-4xufA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 LYS A 644
LEU A 668
TYR A 693
ARG A 810
 P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
None
 1.16A 4bkjB-4xufA:
25.1		 4bkjB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
LYS A 644
GLU A 661
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.41A 4c8bA-4rt7A:
26.8		 4c8bA-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 VAL A 624
ILE A 674
TYR A 693
ILE A 827
 None
None
P30  A1001 (-4.1A)
P30  A1001 ( 4.8A)
 0.42A 4c8bA-4rt7A:
26.8		 4c8bA-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 VAL A 624
ILE A 674
TYR A 693
ILE A 827
 P30  A1001 ( 4.8A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.7A)
 0.35A 4c8bA-4xufA:
26.3		 4c8bA-4xufA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 ALA A 642
LYS A 644
GLU A 661
ILE A 674
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.77A 4c8bB-4rt7A:
19.9		 4c8bB-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 ALA A 642
LYS A 644
GLU A 661
ILE A 674
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.75A 4c8bB-4xufA:
26.0		 4c8bB-4xufA:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 10 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.48A 4ckjA-4rt7A:
27.2		 4ckjA-4rt7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 10 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.42A 4ckjA-4xufA:
23.8		 4ckjA-4xufA:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.82A 4csvA-4rt7A:
26.3		 4csvA-4rt7A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
GLU A 661
MET A 665
VAL A 675
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 1.05A 4csvA-4rt7A:
26.3		 4csvA-4rt7A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
GLU A 661
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.78A 4csvA-4xufA:
26.4		 4csvA-4xufA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.00A 4csvA-4xufA:
26.4		 4csvA-4xufA:
41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.73A 4i22A-4rt7A:
24.2		 4i22A-4rt7A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.62A 4i22A-4xufA:
27.0		 4i22A-4xufA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 11 VAL A 624
ALA A 642
LYS A 644
ASP A 698
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
None
 0.92A 4iaaA-4rt7A:
12.5		 4iaaA-4rt7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 877
LEU A 878
LEU A 939
ILE A 827
HIS A 809
 None
None
None
P30  A1001 (-4.7A)
P30  A1001 (-4.4A)
 0.94A 4j24A-4xufA:
undetectable		 4j24A-4xufA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 877
LEU A 878
LEU A 939
ILE A 827
HIS A 809
 None
None
None
P30  A1001 (-4.7A)
P30  A1001 (-4.4A)
 0.98A 4j24B-4xufA:
undetectable		 4j24B-4xufA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.86A 4mxoA-4xufA:
23.9		 4mxoA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.80A 4mxoB-4xufA:
24.0		 4mxoB-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.87A 4mxxA-4xufA:
29.5		 4mxxA-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.68A 4mxxB-4rt7A:
25.6		 4mxxB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.82A 4mxxB-4rt7A:
25.6		 4mxxB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.74A 4mxxB-4xufA:
23.3		 4mxxB-4xufA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.93A 4mxyA-4xufA:
23.1		 4mxyA-4xufA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.58A 4mxyB-4rt7A:
25.3		 4mxyB-4rt7A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.47A 4mxyB-4xufA:
30.0		 4mxyB-4xufA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.93A 4mxzA-4xufA:
23.1		 4mxzA-4xufA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.58A 4mxzB-4rt7A:
25.3		 4mxzB-4rt7A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.47A 4mxzB-4xufA:
30.0		 4mxzB-4xufA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 11 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
ASN A 816
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.62A 4o0sA-4rt7A:
19.0		 4o0sA-4rt7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.46A 4o0wA-4rt7A:
18.9		 4o0wA-4rt7A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 7 ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 (-3.4A)
None
None
None
P30  A1001 (-4.6A)
 0.70A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 7 CYH A 694
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 None
None
None
P30  A1001 (-4.6A)
None
 0.90A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 7 GLY A 617
ALA A 642
CYH A 694
ASP A 698
LEU A 818
 None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-4.6A)
 0.82A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 7 ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
None
P30  A1001 (-4.3A)
 0.80A 4ogrE-4xufA:
15.9		 4ogrE-4xufA:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 7 GLY A 617
ALA A 642
CYH A 694
ASP A 698
LEU A 818
 None
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.3A)
 0.92A 4ogrE-4xufA:
15.9		 4ogrE-4xufA:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 VAL A 624
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 None
P30  A1001 (-3.4A)
None
None
None
P30  A1001 (-4.6A)
 0.75A 4ogrI-4rt7A:
17.3		 4ogrI-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 VAL A 624
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
None
P30  A1001 (-4.3A)
 0.81A 4ogrI-4xufA:
15.8		 4ogrI-4xufA:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
GLY A 622
VAL A 624
ALA A 642
LYS A 644
VAL A 675
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
 0.53A 4otiA-4rt7A:
14.1		 4otiA-4rt7A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
GLY A 622
VAL A 624
ALA A 642
VAL A 675
LEU A 818
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.45A 4otiA-4rt7A:
14.1		 4otiA-4rt7A:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
LYS A 644
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.88A 4otwA-4xufA:
23.3		 4otwA-4xufA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
LEU A 802
CYH A 807
ARG A 810
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
None
 1.01A 4qrcA-4rt7A:
28.4		 4qrcA-4rt7A:
40.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
ARG A 810
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
None
P30  A1001 ( 4.1A)
 1.11A 4qrcA-4xufA:
33.7		 4qrcA-4xufA:
47.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
GLU A 661
LEU A 802
ARG A 810
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
None
P30  A1001 ( 4.1A)
 1.01A 4qrcA-4xufA:
33.7		 4qrcA-4xufA:
47.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LYS A 644
GLU A 661
MET A 665
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.85A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
CYH A 807
LEU A 818
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 (-4.6A)
P30  A1001 (-3.9A)
 0.51A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.39A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.54A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
MET A 665
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.72A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 LEU A 616
VAL A 675
TYR A 693
ARG A 810
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.4A)
None
 0.81A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 4tyjA-4rt7A:
29.7		 4tyjA-4rt7A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.65A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 6 LEU A 616
VAL A 624
ILE A 674
ILE A 827
 P30  A1001 (-3.8A)
None
None
P30  A1001 ( 4.8A)
 0.25A 4tyjA-4rt7A:
29.7		 4tyjA-4rt7A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 6 LEU A 616
VAL A 624
LYS A 644
ILE A 674
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.45A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 6 LEU A 616
VAL A 624
LYS A 644
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.7A)
 0.70A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 10 LEU A 616
VAL A 624
GLU A 661
LEU A 668
ILE A 674
VAL A 675
TYR A 693
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.6A)
None
None
None
P30  A1001 (-4.1A)
P30  A1001 ( 4.8A)
 0.69A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
ILE A 674
VAL A 675
TYR A 693
ARG A 810
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.7A)
 0.83A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 10 LEU A 616
VAL A 624
GLU A 661
LEU A 668
ILE A 674
VAL A 675
TYR A 693
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.7A)
 0.64A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
LYS A 644
CYH A 694
GLY A 697
CYH A 807
LEU A 818
CYH A 828
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.56A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 ALA A 642
LYS A 644
CYH A 694
GLY A 697
HIS A 809
LEU A 818
CYH A 828
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.9A)
 0.34A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		9 / 12 ALA A 642
LYS A 644
CYH A 694
GLY A 697
HIS A 809
LEU A 818
CYH A 828
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
None
P30  A1001 ( 4.1A)
 0.52A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 11 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
ASN A 816
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
None
 0.66A 4u5jA-4rt7A:
24.8		 4u5jA-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 11 LEU A 616
GLY A 619
VAL A 624
ALA A 642
TYR A 693
GLY A 697
ASN A 816
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
 0.64A 4u5jA-4xufA:
30.7		 4u5jA-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 9 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.71A 4u5jB-4rt7A:
24.7		 4u5jB-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 9 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.72A 4u5jB-4xufA:
24.3		 4u5jB-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.71A 4uxqA-4rt7A:
29.5		 4uxqA-4rt7A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.78A 4uxqA-4rt7A:
29.5		 4uxqA-4rt7A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.61A 4uxqA-4xufA:
34.0		 4uxqA-4xufA:
47.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.86A 4uxqA-4xufA:
34.0		 4uxqA-4xufA:
47.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.69A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.78A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
MET A 664
MET A 665
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
None
 0.87A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
 0.68A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
VAL A 624
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.34A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
LYS A 644
TYR A 693
ARG A 810
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 1.27A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 9 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.58A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.61A 4v01B-4rt7A:
26.2		 4v01B-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.80A 4v01B-4xufA:
33.6		 4v01B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 ALA A 642
GLU A 661
MET A 664
MET A 665
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
None
 0.72A 4v01B-4xufA:
33.6		 4v01B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.37A 4v01B-4rt7A:
26.2		 4v01B-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 9 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.60A 4v01B-4xufA:
33.6		 4v01B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
CYH A 807
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
None
 0.96A 4v04A-4rt7A:
28.4		 4v04A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.84A 4v04A-4rt7A:
28.4		 4v04A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
 0.69A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 8 LYS A 644
MET A 665
TYR A 693
LEU A 818
 P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.79A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 8 LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.53A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 8 LYS A 644
TYR A 693
LEU A 818
PHE A 830
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.71A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.62A 4v04B-4rt7A:
29.0		 4v04B-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.51A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 VAL A 624
LYS A 644
MET A 665
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.74A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.82A 4v04B-4rt7A:
29.0		 4v04B-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
MET A 664
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.85A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
 0.71A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 4wkqA-4rt7A:
30.1		 4wkqA-4rt7A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.65A 4wkqA-4xufA:
29.2		 4wkqA-4xufA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 4xeyA-4rt7A:
27.8		 4xeyA-4rt7A:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.63A 4xliA-4rt7A:
26.4		 4xliA-4rt7A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.75A 4xliA-4xufA:
31.5		 4xliA-4xufA:
41.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.75A 4xliB-4rt7A:
27.6		 4xliB-4rt7A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 4xliB-4xufA:
30.9		 4xliB-4xufA:
41.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
GLY A 617
ALA A 642
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 5ajqA-4rt7A:
22.3		 5ajqA-4rt7A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
GLY A 617
ALA A 642
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.71A 5ajqA-4xufA:
22.7		 5ajqA-4xufA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.52A 5bvwA-4rt7A:
28.6		 5bvwA-4rt7A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.50A 5bvwA-4xufA:
25.2		 5bvwA-4xufA:
33.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.49A 5h2uA-4rt7A:
25.6		 5h2uA-4rt7A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.46A 5h2uA-4xufA:
22.8		 5h2uA-4xufA:
36.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 ( 4.3A)
 0.52A 5hi2A-4rt7A:
19.1		 5hi2A-4rt7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 802
HIS A 809
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.4A)
 0.49A 5hi2A-4xufA:
27.6		 5hi2A-4xufA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 GLY A 617
GLY A 619
GLY A 622
VAL A 624
 None
None
None
P30  A1001 ( 4.8A)
 0.17A 5izjB-4xufA:
15.0		 5izjB-4xufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 GLY A 617
GLY A 619
VAL A 624
LYS A 644
 None
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
 0.48A 5izjA-4xufA:
13.2		 5izjA-4xufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 7 GLY A 617
GLY A 619
VAL A 624
LYS A 644
 None
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
 0.42A 5j5xA-4xufA:
14.9		 5j5xA-4xufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
P30  A1001 (-4.6A)
 0.51A 5l2iA-4rt7A:
6.7		 5l2iA-4rt7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.3A)
 0.54A 5l2iA-4xufA:
6.9		 5l2iA-4xufA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
P30  A1001 (-4.6A)
 0.81A 5l2tA-4rt7A:
6.8		 5l2tA-4rt7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
VAL A 675
PHE A 691
ASP A 698
LEU A 818
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.3A)
None
P30  A1001 (-4.3A)
 0.76A 5l2tA-4xufA:
7.0		 5l2tA-4xufA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 11 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.44A 5lvnA-4rt7A:
22.9		 5lvnA-4rt7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
 None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 0.66A 5mafA-4rt7A:
23.2		 5mafA-4rt7A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.76A 5mafA-4xufA:
23.3		 5mafA-4xufA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
VAL A 624
LYS A 644
GLU A 661
GLY A 697
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.1A)
 0.83A 5mo4A-4xufA:
11.6		 5mo4A-4xufA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 ALA A 642
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.71A 5mo4A-4rt7A:
27.1		 5mo4A-4rt7A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
MET A 665
VAL A 675
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.97A 5mo4A-4xufA:
11.6		 5mo4A-4xufA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.52A 5n3hA-4rt7A:
16.1		 5n3hA-4rt7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 10 LEU A 616
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.45A 5n3hA-4xufA:
14.7		 5n3hA-4xufA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 8 ALA A 642
GLU A 661
CYH A 694
LEU A 818
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
 0.42A 5owrA-4rt7A:
20.2		 5owrA-4rt7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 8 ALA A 642
GLU A 661
CYH A 694
LEU A 818
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
 0.51A 5owrA-4xufA:
20.7		 5owrA-4xufA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 LEU A 616
VAL A 624
CYH A 694
CYH A 828
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-4.1A)
 0.44A 5te0A-4rt7A:
23.0		 5te0A-4rt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		4 / 5 LEU A 616
VAL A 624
CYH A 694
CYH A 828
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.2A)
P30  A1001 (-4.8A)
 0.58A 5te0A-4xufA:
22.6		 5te0A-4xufA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
 0.83A 5vc3A-4rt7A:
17.7		 5vc3A-4rt7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
 0.70A 5vc3A-4rt7A:
17.7		 5vc3A-4rt7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 ALA A 642
GLU A 661
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 1.06A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
 None
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 1.17A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 None
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 0.77A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
GLU A 661
VAL A 675
LEU A 689
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 (-3.4A)
 1.01A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
 1.12A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
 1.03A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		6 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 689
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
None
 0.78A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
 0.83A 5vcyA-4rt7A:
22.1		 5vcyA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.2A)
 0.74A 5vcyA-4xufA:
22.2		 5vcyA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 MET A 665
GLY A 798
GLU A 800
ASP A 870
PHE A 936
 P30  A1001 ( 3.7A)
None
None
None
None
 1.50A 5vlmF-4rt7A:
undetectable		 5vlmF-4rt7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
ALA A 642
VAL A 675
CYH A 694
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
None
None
P30  A1001 (-3.4A)
 0.42A 5w5vA-4rt7A:
14.0		 5w5vA-4rt7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 9 LEU A 616
ALA A 642
VAL A 675
CYH A 694
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
 0.55A 5w5vA-4xufA:
11.7		 5w5vA-4xufA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
PHE A 691
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.7A)
 0.19A 5xv7A-4rt7A:
20.9		 5xv7A-4rt7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		5 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
PHE A 691
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.3A)
 0.47A 5xv7A-4xufA:
20.6		 5xv7A-4xufA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.72A 5y7zA-4rt7A:
15.9		 5y7zA-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.72A 5y7zA-4rt7A:
15.9		 5y7zA-4rt7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y7zA-4xufA:
22.1		 5y7zA-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y7zA-4xufA:
22.1		 5y7zA-4xufA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.63A 5y7zB-4rt7A:
22.5		 5y7zB-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
CYH A 828
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
 0.79A 5y7zB-4rt7A:
22.5		 5y7zB-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
 0.70A 5y7zB-4xufA:
22.2		 5y7zB-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.80A 5y7zB-4xufA:
22.2		 5y7zB-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.49A 5y80A-4rt7A:
22.3		 5y80A-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y80A-4xufA:
21.9		 5y80A-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
LEU A 689
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.89A 5yu9A-4rt7A:
24.1		 5yu9A-4rt7A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
PHE A 830
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.9A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 1.16A 5zv2A-4rt7A:
28.9		 5zv2A-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 0.75A 5zv2A-4rt7A:
28.9		 5zv2A-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
 None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
 1.23A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
 1.11A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.80A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
GLY A 697
 P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.90A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
 0.74A 5zv2B-4rt7A:
29.0		 5zv2B-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
 None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
 1.18A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
 1.17A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
 0.81A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
 P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
 0.90A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.54A 6bsdA-4rt7A:
28.0		 6bsdA-4rt7A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.41A 6bsdA-4xufA:
31.8		 6bsdA-4xufA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.62A 6hd4A-4xufA:
27.6		 6hd4A-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.63A 6hd4B-4xufA:
33.4		 6hd4B-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.64A 6hd6A-4xufA:
33.5		 6hd6A-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 VAL A 624
ALA A 642
LYS A 644
MET A 665
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.3A)
None
 0.95A 6hd6A-4xufA:
33.5		 6hd6A-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
 0.68A 6hd6B-4rt7A:
34.2		 6hd6B-4rt7A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		7 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
 0.92A 6hd6B-4rt7A:
34.2		 6hd6B-4rt7A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens) 		8 / 12 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.72A 6hd6B-4xufA:
33.2		 6hd6B-4xufA:
12.87