SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P2L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 8 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.63A 3u5kA-5ml0A:
15.8		 3u5kA-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 7 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.56A 3u5kB-5ml0A:
15.7		 3u5kB-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 8 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.67A 3u5kD-5ml0A:
15.9		 3u5kD-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 6 PRO A 746
VAL A 751
TYR A 759
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 4.6A)
P2L  A 901 (-3.2A)
 0.40A 5pbeA-5ml0A:
18.3		 5pbeA-5ml0A:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		5 / 8 PRO A 746
VAL A 751
CYH A 798
TYR A 801
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 3.8A)
P2L  A 901 (-4.1A)
P2L  A 901 (-3.2A)
 0.83A 5y1yA-5ml0A:
15.7		 5y1yA-5ml0A:
32.99