SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P1T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 ILE A  91
GLY A 228
THR A 229
HIS A 201
GLY A 225
 None
P1T  A 702 (-3.9A)
P1T  A 702 (-3.6A)
None
P1T  A 702 (-3.6A)
 1.07A 1i7qA-3pc3A:
undetectable		 1i7qA-3pc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 10 ILE A  91
GLY A 228
THR A 229
HIS A 201
GLY A 225
 None
P1T  A 702 (-3.9A)
P1T  A 702 (-3.6A)
None
P1T  A 702 (-3.6A)
 1.09A 1i7qC-3pc3A:
undetectable		 1i7qC-3pc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 10 SER A 318
GLY A 316
GLU A 273
SER A 319
ILE A 347
 P1T  A 702 (-2.7A)
None
None
None
None
 1.42A 1pw7A-3pc3A:
undetectable		 1pw7A-3pc3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 121
GLY A 122
GLY A  92
GLY A 117
ALA A 124
 None
None
None
P1T  A 702 (-4.3A)
None
 1.00A 2fk8A-3pc3A:
3.1		 2fk8A-3pc3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 ASN A 349
GLY A 122
THR A 115
ILE A 136
LEU A 150
 None
None
P1T  A 702 (-3.7A)
None
None
 1.21A 3bf1A-3pc3A:
undetectable
3bf1B-3pc3A:
undetectable		 3bf1A-3pc3A:
18.63
3bf1B-3pc3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 ASN A 349
GLY A 122
THR A 115
ILE A 136
LEU A 150
 None
None
P1T  A 702 (-3.7A)
None
None
 1.20A 3bf1C-3pc3A:
undetectable
3bf1D-3pc3A:
undetectable		 3bf1C-3pc3A:
18.63
3bf1D-3pc3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 LEU A 150
ASN A 349
GLY A 122
THR A 115
ILE A 136
 None
None
None
P1T  A 702 (-3.7A)
None
 1.22A 3bf1C-3pc3A:
undetectable
3bf1D-3pc3A:
undetectable		 3bf1C-3pc3A:
18.63
3bf1D-3pc3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 ALA A 200
GLY A 232
ILE A 233
THR A 226
ILE A  91
 None
HEM  A 701 ( 3.9A)
None
P1T  A 702 (-2.8A)
None
 0.94A 3ekxA-3pc3A:
undetectable		 3ekxA-3pc3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		3 / 3 ASN A 118
ASP A 345
ASN A 349
 P1T  A 702 (-3.8A)
P1T  A 702 (-3.3A)
None
 0.71A 4agaA-3pc3A:
undetectable		 4agaA-3pc3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ASN A 349
GLY A 122
THR A 115
ILE A 136
LEU A 150
 None
None
P1T  A 702 (-3.7A)
None
None
 1.13A 4o5fA-3pc3A:
undetectable
4o5fB-3pc3A:
undetectable		 4o5fA-3pc3A:
20.26
4o5fB-3pc3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 150
ASN A 349
GLY A 122
THR A 115
ILE A 136
 None
None
None
P1T  A 702 (-3.7A)
None
 1.13A 4o5fA-3pc3A:
undetectable
4o5fB-3pc3A:
undetectable		 4o5fA-3pc3A:
20.26
4o5fB-3pc3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		4 / 6 TYR A 277
GLU A 113
LEU A 172
GLN A 191
 None
None
None
P1T  A 702 (-2.9A)
 1.50A 4qztA-3pc3A:
undetectable		 4qztA-3pc3A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ASN A 349
GLY A 122
THR A 115
ILE A 136
LEU A 150
 None
None
P1T  A 702 (-3.7A)
None
None
 1.15A 5b8hA-3pc3A:
undetectable
5b8hB-3pc3A:
undetectable		 5b8hA-3pc3A:
18.01
5b8hB-3pc3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 150
ASN A 349
GLY A 122
THR A 115
ILE A 136
 None
None
None
P1T  A 702 (-3.7A)
None
 1.13A 5b8hA-3pc3A:
undetectable
5b8hB-3pc3A:
undetectable		 5b8hA-3pc3A:
18.01
5b8hB-3pc3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 209
VAL A 221
VAL A 222
LEU A  58
THR A 229
 None
None
None
None
P1T  A 702 (-3.6A)
 1.12A 5bykA-3pc3A:
undetectable		 5bykA-3pc3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		4 / 8 ILE A 111
GLY A  92
THR A 119
ASN A 194
 None
None
P1T  A 702 (-3.9A)
None
 1.02A 5hwaA-3pc3A:
undetectable		 5hwaA-3pc3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		4 / 5 SER A 223
VAL A 249
GLY A 321
ALA A 322
 P1T  A 702 ( 3.7A)
None
None
None
 1.08A 5k50A-3pc3A:
undetectable		 5k50A-3pc3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3pc3 CG1753, ISOFORM A
(Drosophila
melanogaster) 		3 / 3 ASP A  89
ASN A 197
GLN A 191
 None
P1T  A 702 ( 4.7A)
P1T  A 702 (-2.9A)
 0.78A 5k7uA-3pc3A:
undetectable		 5k7uA-3pc3A:
18.08