SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P1A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 ILE E 331
MET E 372
ARG E 375
 P1A  E 601 (-4.4A)
P1A  E 601 (-4.0A)
P1A  E 601 (-3.9A)
 0.94A 4lnwA-4oztE:
25.3		 4lnwA-4oztE:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 LEU E 440
MET E 400
TYR E 447
 None
P1A  E   5 ( 4.4A)
None
 0.60A 4p6xG-2nxxE:
22.5		 4p6xG-2nxxE:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4ozt ECDYSONE RECEPTOR
(Pediculus
humanus) 		3 / 3 LEU E 413
MET E 373
TYR E 420
 None
P1A  E 601 ( 4.4A)
None
 0.63A 4p6xG-4oztE:
22.3		 4p6xG-4oztE:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 THR E 365
HIS E 441
LEU E 517
 P1A  E   5 ( 3.7A)
None
None
 0.85A 5axdC-2nxxE:
undetectable		 5axdC-2nxxE:
20.65