SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P16'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.83A 1iepA-1opkA:
34.6
1iepA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.70A 1iepA-1opkA:
34.6
1iepA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.60A 1iepA-1opkA:
34.6
1iepA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 VAL A 308
VAL A 318
ILE A 332
MET A 337
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.50A 1iepA-1opkA:
34.6
1iepA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
0.77A 1iepB-1opkA:
34.7
1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
0.78A 1iepB-1opkA:
34.7
1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 7 LYS A 290
VAL A 308
VAL A 318
ILE A 332
MET A 337
LEU A 389
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
P16  A   2 (-4.4A)
0.65A 1iepB-1opkA:
34.7
1iepB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 VAL A 318
ILE A 332
MET A 337
ARG A 381
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
None
0.94A 1iepB-1opkA:
34.7
1iepB-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 8 LEU A 346
VAL A 390
CYH A 388
GLY A 340
None
None
None
P16  A   2 (-3.4A)
1.05A 1jlfA-1opkA:
2.2
1jlfB-1opkA:
1.9
1jlfA-1opkA:
21.60
1jlfB-1opkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.70A 1m17A-1opkA:
31.9
1m17A-1opkA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae)
4 / 6 ASN P   5
ASN P  74
ILE P  56
GLY P  57
None
None
None
SF4  P1610 ( 4.9A)
0.95A 1oniA-4crmP:
undetectable
1oniB-4crmP:
undetectable
1oniA-4crmP:
14.11
1oniB-4crmP:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae)
4 / 6 ASN P   5
ASN P  74
ILE P  56
GLY P  57
None
None
None
SF4  P1610 ( 4.9A)
0.95A 1oniD-4crmP:
undetectable
1oniF-4crmP:
undetectable
1oniD-4crmP:
14.11
1oniF-4crmP:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.67A 1opjA-1opkA:
37.3
1opjA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.60A 1opjA-1opkA:
37.3
1opjA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 LYS A 290
VAL A 308
ILE A 332
MET A 337
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
0.55A 1opjA-1opkA:
37.3
1opjA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 TYR A 272
VAL A 308
ILE A 332
MET A 337
P16  A   2 (-3.6A)
None
P16  A   2 (-4.1A)
None
0.75A 1opjA-1opkA:
37.3
1opjA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
0.77A 1opjB-1opkA:
37.1
1opjB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
PHE A 336
GLY A 340
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
0.70A 1opjB-1opkA:
37.1
1opjB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
0.53A 1opjB-1opkA:
37.1
1opjB-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.42A 1t46A-1opkA:
30.7
1t46A-1opkA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.54A 1uwhA-1opkA:
26.6
1uwhA-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.53A 1uwhB-1opkA:
26.5
1uwhB-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 VAL A 275
ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.66A 1uwjA-1opkA:
7.1
1uwjA-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 VAL A 275
ALA A 288
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.66A 1uwjB-1opkA:
7.1
1uwjB-1opkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 THR A 334
GLY A 340
LEU A 343
ASP A 344
ARG A 347
LEU A 389
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
None
None
P16  A   2 (-4.4A)
0.75A 1xkkA-1opkA:
29.2
1xkkA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 9 LEU A 267
VAL A 275
LYS A 290
LEU A 320
MET A 337
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
None
0.64A 1xkkA-1opkA:
29.2
1xkkA-1opkA:
24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.82A 2gqgA-1opkA:
37.1
2gqgA-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.80A 2gqgA-1opkA:
37.1
2gqgA-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.57A 2gqgB-1opkA:
37.9
2gqgB-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.62A 2gqgB-1opkA:
37.9
2gqgB-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 2gqgB-1opkA:
37.9
2gqgB-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 2gqgB-1opkA:
37.9
2gqgB-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
PHE A 336
GLY A 340
LEU A 389
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.87A 2hyyA-1opkA:
34.9
2hyyA-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.78A 2hyyA-1opkA:
34.9
2hyyA-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.59A 2hyyA-1opkA:
34.9
2hyyA-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
ARG A 381
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
1.01A 2hyyA-1opkA:
34.9
2hyyA-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.88A 2hyyB-1opkA:
34.7
2hyyB-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.69A 2hyyB-1opkA:
34.7
2hyyB-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.54A 2hyyB-1opkA:
34.7
2hyyB-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LEU A 267
VAL A 308
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
0.44A 2hyyB-1opkA:
34.7
2hyyB-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
ILE A 312
VAL A 318
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.84A 2hyyC-1opkA:
35.2
2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
MET A 309
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
0.53A 2hyyC-1opkA:
35.2
2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
VAL A 308
MET A 309
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
None
0.44A 2hyyC-1opkA:
35.2
2hyyC-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.87A 2hyyD-1opkA:
34.8
2hyyD-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.74A 2hyyD-1opkA:
34.8
2hyyD-1opkA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 4 LEU A 267
LYS A 290
VAL A 318
MET A 337
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
None
0.58A 2hyyD-1opkA:
34.8
2hyyD-1opkA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
0.81A 2itoA-1opkA:
30.3
2itoA-1opkA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.83A 2itoA-1opkA:
30.3
2itoA-1opkA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.94A 2ityA-1opkA:
30.3
2ityA-1opkA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
0.82A 2itzA-1opkA:
30.1
2itzA-1opkA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.89A 2itzA-1opkA:
30.1
2itzA-1opkA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.69A 2oiqA-1opkA:
31.7
2oiqA-1opkA:
30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.74A 2pl0A-1opkA:
30.2
2pl0A-1opkA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.5A)
0.72A 2pl0A-1opkA:
30.2
2pl0A-1opkA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.87A 2pl0A-1opkA:
30.2
2pl0A-1opkA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 332
THR A 334
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.5A)
0.78A 2pl0A-1opkA:
30.2
2pl0A-1opkA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 9 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.58A 2xp2A-1opkA:
30.8
2xp2A-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.61A 2y6oA-1opkA:
31.7
2y6oA-1opkA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 8 LEU A 267
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.50A 2yfxA-1opkA:
30.6
2yfxA-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 GLN A 319
THR A 334
HIS A 380
LEU A 403
None
P16  A   2 (-3.7A)
None
None
1.39A 2zj0A-1opkA:
undetectable
2zj0A-1opkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
MET A 337
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.76A 2zvaA-1opkA:
32.2
2zvaA-1opkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.77A 2zvaA-1opkA:
32.2
2zvaA-1opkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 10 LEU A 267
ALA A 288
VAL A 318
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 3aoxA-1opkA:
30.4
3aoxA-1opkA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
GLU A 277
ALA A 288
LYS A 290
VAL A 318
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.60A 3c7qA-1opkA:
29.6
3c7qA-1opkA:
26.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LYS A 304
ILE A 332
PHE A 336
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
0.98A 3cs9A-1opkA:
34.8
3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
TYR A 272
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
0.82A 3cs9A-1opkA:
34.8
3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
PHE A 336
VAL A 398
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
0.64A 3cs9A-1opkA:
34.8
3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 ALA A 288
GLU A 305
VAL A 308
MET A 309
LEU A 317
THR A 334
GLY A 340
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 3cs9A-1opkA:
34.8
3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.70A 3cs9A-1opkA:
34.8
3cs9A-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 ALA A 288
GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
0.66A 3cs9B-1opkA:
34.3
3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 9 LEU A 267
TYR A 272
VAL A 275
LYS A 290
VAL A 318
ILE A 332
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
0.73A 3cs9B-1opkA:
34.3
3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 9 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
LEU A 389
VAL A 398
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
None
0.53A 3cs9B-1opkA:
34.3
3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 9 LEU A 267
VAL A 275
VAL A 318
ILE A 332
PHE A 378
LEU A 389
VAL A 398
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
P16  A   2 (-4.4A)
None
0.68A 3cs9B-1opkA:
34.3
3cs9B-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 ALA A 288
GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
PHE A 336
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.5A)
0.68A 3cs9C-1opkA:
34.2
3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
PHE A 378
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
None
1.37A 3cs9C-1opkA:
34.2
3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 9 LEU A 267
VAL A 275
LYS A 290
VAL A 318
ILE A 332
MET A 337
VAL A 398
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
None
0.64A 3cs9C-1opkA:
34.2
3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 9 TYR A 272
VAL A 275
VAL A 318
ILE A 332
MET A 337
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
1.00A 3cs9C-1opkA:
34.2
3cs9C-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 ALA A 288
GLU A 305
VAL A 308
MET A 309
LEU A 317
THR A 334
PHE A 336
GLY A 340
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
0.59A 3cs9D-1opkA:
33.0
3cs9D-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 GLU A 305
VAL A 308
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
ALA A 399
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
0.72A 3cs9D-1opkA:
33.0
3cs9D-1opkA:
57.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
TYR A 272
VAL A 275
LYS A 290
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.4A)
0.72A 3cs9D-1opkA:
33.0
3cs9D-1opkA:
57.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 11 LEU A 267
VAL A 275
ALA A 288
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.39A 3g0eA-1opkA:
29.3
3g0eA-1opkA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 11 LEU A 267
VAL A 275
ALA A 288
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.38A 3g0fA-1opkA:
30.2
3g0fA-1opkA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 10 LEU A 267
VAL A 275
ALA A 288
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.33A 3g0fB-1opkA:
30.5
3g0fB-1opkA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.58A 3g5dA-1opkA:
32.4
3g5dA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.64A 3g5dA-1opkA:
32.4
3g5dA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.78A 3g5dB-1opkA:
32.5
3g5dB-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.61A 3gvuA-1opkA:
35.4
3gvuA-1opkA:
54.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
LEU A 389
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.85A 3gvuA-1opkA:
35.4
3gvuA-1opkA:
54.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.72A 3gvuA-1opkA:
35.4
3gvuA-1opkA:
54.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 LYS A 290
VAL A 308
ILE A 332
MET A 337
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
0.60A 3gvuA-1opkA:
35.4
3gvuA-1opkA:
54.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 3ik3A-1opkA:
34.8
3ik3A-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLU A 305
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
0.63A 3ik3A-1opkA:
34.8
3ik3A-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 LEU A 267
LYS A 290
VAL A 308
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
0.53A 3ik3A-1opkA:
34.8
3ik3A-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 LEU A 267
VAL A 308
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
0.34A 3ik3A-1opkA:
34.8
3ik3A-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.57A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLU A 305
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
0.67A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 LEU A 267
LYS A 290
VAL A 308
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
0.50A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 LEU A 267
VAL A 308
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
0.35A 3ik3B-1opkA:
34.6
3ik3B-1opkA:
57.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.79A 3k54A-1opkA:
30.3
3k54A-1opkA:
29.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.81A 3k5vA-1opkA:
37.0
3k5vA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.71A 3k5vA-1opkA:
37.0
3k5vA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.52A 3k5vA-1opkA:
37.0
3k5vA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LEU A 267
VAL A 308
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
0.45A 3k5vA-1opkA:
37.0
3k5vA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.83A 3k5vB-1opkA:
37.2
3k5vB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.68A 3k5vB-1opkA:
37.2
3k5vB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.50A 3k5vB-1opkA:
37.2
3k5vB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
VAL A 308
VAL A 318
ILE A 332
MET A 337
P16  A   2 ( 4.2A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.47A 3k5vB-1opkA:
37.2
3k5vB-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 8 ALA A 288
LYS A 290
GLU A 305
THR A 334
MET A 337
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
0.45A 3lfaA-1opkA:
19.7
3lfaA-1opkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 11 ALA A 288
VAL A 318
PHE A 336
MET A 337
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 3miyA-1opkA:
30.8
3miyA-1opkA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 9 ALA A 288
PHE A 336
MET A 337
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.59A 3miyB-1opkA:
31.0
3miyB-1opkA:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
PHE A 336
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
0.79A 3ms9A-1opkA:
34.3
3ms9A-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.76A 3ms9A-1opkA:
34.3
3ms9A-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
MET A 337
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.57A 3ms9A-1opkA:
34.3
3ms9A-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LYS A 290
VAL A 318
ILE A 332
MET A 337
ARG A 381
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
None
0.95A 3ms9A-1opkA:
34.3
3ms9A-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.74A 3ms9B-1opkA:
34.5
3ms9B-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 7 LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.54A 3ms9B-1opkA:
34.5
3ms9B-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 7 TYR A 272
VAL A 308
VAL A 318
ILE A 332
MET A 337
P16  A   2 (-3.6A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.70A 3ms9B-1opkA:
34.5
3ms9B-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.76A 3mssA-1opkA:
34.5
3mssA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.74A 3mssA-1opkA:
34.5
3mssA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.47A 3mssA-1opkA:
34.5
3mssA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 318
ILE A 332
ARG A 381
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.97A 3mssA-1opkA:
34.5
3mssA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 VAL A 308
VAL A 318
ILE A 332
MET A 337
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.46A 3mssA-1opkA:
34.5
3mssA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLU A 305
MET A 309
ILE A 312
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.64A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLU A 305
MET A 309
ILE A 312
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.60A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.68A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.63A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 7 TYR A 272
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.90A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 7 TYR A 272
VAL A 308
VAL A 318
ILE A 332
MET A 337
P16  A   2 (-3.6A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.73A 3mssB-1opkA:
34.6
3mssB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.78A 3mssC-1opkA:
34.5
3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.75A 3mssC-1opkA:
34.5
3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.48A 3mssC-1opkA:
34.5
3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 318
ILE A 332
ARG A 381
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
1.00A 3mssC-1opkA:
34.5
3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 VAL A 308
VAL A 318
ILE A 332
MET A 337
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.48A 3mssC-1opkA:
34.5
3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.79A 3mssD-1opkA:
34.6
3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
TYR A 272
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.84A 3mssD-1opkA:
34.6
3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 VAL A 275
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.52A 3mssD-1opkA:
34.6
3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 VAL A 275
VAL A 308
VAL A 318
ILE A 332
MET A 337
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
0.50A 3mssD-1opkA:
34.6
3mssD-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
THR A 334
GLY A 340
GLU A 348
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
1.12A 3octA-1opkA:
32.5
3octA-1opkA:
28.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.57A 3oezA-1opkA:
31.3
3oezA-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.49A 3oezA-1opkA:
31.3
3oezA-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.69A 3oezA-1opkA:
31.3
3oezA-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.63A 3oezA-1opkA:
31.3
3oezA-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 ALA A 288
LYS A 290
GLU A 305
VAL A 308
MET A 309
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.66A 3oezB-1opkA:
31.4
3oezB-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 VAL A 275
ALA A 288
LYS A 290
VAL A 308
MET A 309
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.67A 3oezB-1opkA:
31.4
3oezB-1opkA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae)
3 / 3 GLN P 127
THR P 118
LEU P 131
None
ATP  P1609 (-3.6A)
None
0.75A 3ondA-4crmP:
undetectable
3ondA-4crmP:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae)
3 / 3 GLN P 127
THR P 118
LEU P 131
None
ATP  P1609 (-3.6A)
None
0.76A 3ondB-4crmP:
undetectable
3ondB-4crmP:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
THR A 334
GLY A 340
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.5A)
0.52A 3oxzA-1opkA:
34.6
3oxzA-1opkA:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 317
VAL A 318
THR A 334
GLY A 340
HIS A 380
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
0.50A 3oxzA-1opkA:
34.6
3oxzA-1opkA:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 9 LEU A 267
LYS A 290
VAL A 308
ILE A 332
MET A 337
LEU A 389
VAL A 398
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
P16  A   2 (-4.4A)
None
0.50A 3oxzA-1opkA:
34.6
3oxzA-1opkA:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
0.53A 3pyyA-1opkA:
34.3
3pyyA-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.67A 3pyyA-1opkA:
34.3
3pyyA-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LYS A 290
VAL A 318
ILE A 332
ARG A 381
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
1.02A 3pyyA-1opkA:
34.3
3pyyA-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 TYR A 272
LYS A 290
VAL A 308
VAL A 318
ILE A 332
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
0.92A 3pyyA-1opkA:
34.3
3pyyA-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.77A 3pyyB-1opkA:
34.6
3pyyB-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 3pyyB-1opkA:
34.6
3pyyB-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 5 LYS A 290
VAL A 308
ILE A 332
MET A 337
ARG A 381
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
None
0.93A 3pyyB-1opkA:
34.6
3pyyB-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.81A 3qlgA-1opkA:
31.7
3qlgA-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.76A 3qlgB-1opkA:
32.0
3qlgB-1opkA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.62A 3sxrA-1opkA:
33.1
3sxrA-1opkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.58A 3sxrB-1opkA:
32.9
3sxrB-1opkA:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
ALA A 288
GLU A 305
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
PHE A 401
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
0.95A 3ue4A-1opkA:
37.4
3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.73A 3ue4A-1opkA:
37.4
3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
ALA A 288
LYS A 290
VAL A 318
ILE A 332
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.65A 3ue4A-1opkA:
37.4
3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
ALA A 288
VAL A 318
THR A 334
PHE A 336
MET A 337
GLY A 340
LEU A 389
PHE A 401
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
0.78A 3ue4A-1opkA:
37.4
3ue4A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.67A 3ue4B-1opkA:
37.8
3ue4B-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
PHE A 336
GLY A 340
LEU A 389
PHE A 401
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
None
0.89A 3ue4B-1opkA:
37.8
3ue4B-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 337
GLY A 340
ASP A 344
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.81A 3ug2A-1opkA:
31.8
3ug2A-1opkA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 LEU A 267
GLY A 268
VAL A 275
ALA A 288
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.4A)
0.40A 3wzdA-1opkA:
30.6
3wzdA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
0.37A 3wzdA-1opkA:
30.6
3wzdA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
PHE A 336
GLY A 340
LEU A 373
HIS A 380
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
None
0.44A 3wzeA-1opkA:
30.3
3wzeA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
PHE A 336
GLY A 340
HIS A 380
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
0.54A 3wzeA-1opkA:
30.3
3wzeA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
ARG A 381
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.90A 3zosA-1opkA:
29.5
3zosA-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
ARG A 381
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.92A 3zosB-1opkA:
29.4
3zosB-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
VAL A 318
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.44A 4ag8A-1opkA:
30.7
4ag8A-1opkA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.47A 4agcA-1opkA:
30.2
4agcA-1opkA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 11 LEU A 267
ALA A 288
VAL A 318
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.35A 4agdA-1opkA:
29.8
4agdA-1opkA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 9 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.56A 4anqA-1opkA:
30.6
4anqA-1opkA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 9 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.57A 4ansA-1opkA:
30.5
4ansA-1opkA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
PHE A 336
GLY A 340
LEU A 373
HIS A 380
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
None
0.62A 4asdA-1opkA:
30.0
4asdA-1opkA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.93A 4bkjA-1opkA:
28.8
4bkjA-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.80A 4bkjB-1opkA:
28.8
4bkjB-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.50A 4c8bA-1opkA:
25.4
4c8bA-1opkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
LYS A 290
GLU A 305
THR A 334
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.47A 4c8bB-1opkA:
25.6
4c8bB-1opkA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.65A 4csvA-1opkA:
32.5
4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
LEU A 389
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.63A 4csvA-1opkA:
32.5
4csvA-1opkA:
47.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_2
(SRC-ABL TYROSINE
KINASE ANCESTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 4 LYS A 290
ILE A 332
MET A 337
PHE A 378
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
None
None
0.63A 4csvA-1opkA:
32.2
4csvA-1opkA:
47.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
THR A 334
MET A 337
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
0.67A 4hjoA-1opkA:
29.7
4hjoA-1opkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.63A 4hjoA-1opkA:
29.7
4hjoA-1opkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
GLY A 273
VAL A 275
ALA A 288
LYS A 290
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.87A 4mkcA-1opkA:
30.9
4mkcA-1opkA:
28.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.72A 4mxoA-1opkA:
32.1
4mxoA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
0.86A 4mxoA-1opkA:
32.1
4mxoA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
VAL A 318
ILE A 332
THR A 334
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.70A 4mxoB-1opkA:
32.1
4mxoB-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.73A 4mxoB-1opkA:
32.1
4mxoB-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.88A 4mxxA-1opkA:
32.1
4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 ALA A 288
LYS A 290
GLU A 305
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.78A 4mxxA-1opkA:
32.1
4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.93A 4mxxA-1opkA:
32.1
4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
1.04A 4mxxA-1opkA:
32.1
4mxxA-1opkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.78A 4mxxB-1opkA:
31.6
4mxxB-1opkA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.96A 4mxyB-1opkA:
32.1
4mxyB-1opkA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.96A 4mxzB-1opkA:
32.1
4mxzB-1opkA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
LYS A 290
VAL A 318
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.90A 4otwA-1opkA:
28.5
4otwA-1opkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
LYS A 290
VAL A 318
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 4otwA-1opkA:
28.5
4otwA-1opkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
LYS A 290
GLU A 305
ILE A 332
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.80A 4qmnA-1opkA:
26.0
4qmnA-1opkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
GLU A 305
MET A 309
LEU A 373
ARG A 381
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.5A)
0.83A 4qrcA-1opkA:
30.7
4qrcA-1opkA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 8 LEU A 267
VAL A 275
LYS A 290
HIS A 380
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.4A)
0.48A 4qrcA-1opkA:
30.7
4qrcA-1opkA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
LEU A 389
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
0.45A 4r7iA-1opkA:
30.3
4r7iA-1opkA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 8 LEU A 395
GLY A 391
GLU A 392
ALA A 288
None
GOL  A   3 (-4.9A)
GOL  A   3 (-4.5A)
P16  A   2 (-3.4A)
0.88A 4rjdA-1opkA:
0.0
4rjdB-1opkA:
0.0
4rjdA-1opkA:
12.43
4rjdB-1opkA:
12.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.50A 4twpA-1opkA:
37.7
4twpA-1opkA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 TYR A 272
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.91A 4twpA-1opkA:
37.7
4twpA-1opkA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
TYR A 272
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.80A 4twpB-1opkA:
38.4
4twpB-1opkA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.51A 4twpB-1opkA:
38.4
4twpB-1opkA:
98.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.64A 4tyjA-1opkA:
30.8
4tyjA-1opkA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
LYS A 290
THR A 334
GLY A 340
HIS A 380
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.47A 4u0iA-1opkA:
30.5
4u0iA-1opkA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 11 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.64A 4u5jA-1opkA:
33.6
4u5jA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 9 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.48A 4u5jB-1opkA:
32.9
4u5jB-1opkA:
30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
GLU A 305
ILE A 312
LEU A 373
HIS A 380
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
None
P16  A   2 (-4.4A)
0.85A 4uxqA-1opkA:
30.4
4uxqA-1opkA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
ALA A 288
GLU A 305
LEU A 373
HIS A 380
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.66A 4uxqA-1opkA:
30.4
4uxqA-1opkA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 373
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-3.5A)
0.85A 4v01A-1opkA:
29.9
4v01A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
GLU A 305
MET A 309
LEU A 373
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.5A)
0.59A 4v01B-1opkA:
30.1
4v01B-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 VAL A 275
ALA A 288
GLU A 305
HIS A 380
ALA A 399
GLY A 402
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.5A)
None
1.08A 4v04A-1opkA:
29.6
4v04A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 VAL A 275
ALA A 288
GLU A 305
LEU A 373
HIS A 380
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-3.5A)
0.63A 4v04A-1opkA:
29.6
4v04A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 ALA A 288
GLU A 305
LEU A 373
HIS A 380
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-3.5A)
0.63A 4v04B-1opkA:
29.8
4v04B-1opkA:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 11 ALA A 288
THR A 334
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.52A 4wa9A-1opkA:
33.1
4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 11 LEU A 267
ALA A 288
LYS A 290
THR A 334
MET A 337
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
1.01A 4wa9A-1opkA:
33.1
4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 11 LEU A 267
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.84A 4wa9A-1opkA:
33.1
4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 11 TYR A 272
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.85A 4wa9A-1opkA:
33.1
4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 TYR A 272
VAL A 275
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.79A 4wa9B-1opkA:
37.8
4wa9B-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
THR A 334
PHE A 336
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.54A 4wa9B-1opkA:
37.8
4wa9B-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 6 LEU A 267
ALA A 288
MET A 337
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.50A 4wboC-1opkA:
22.0
4wboC-1opkA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
ALA A 288
GLU A 305
THR A 334
GLY A 340
ASP A 344
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.88A 4wkqA-1opkA:
32.1
4wkqA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.76A 4wkqA-1opkA:
32.1
4wkqA-1opkA:
24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
12 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.63A 4xeyA-1opkA:
37.1
4xeyA-1opkA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
VAL A 318
ILE A 332
THR A 334
PHE A 336
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
0.60A 4xeyB-1opkA:
36.3
4xeyB-1opkA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
VAL A 275
ALA A 288
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.62A 4xeyB-1opkA:
36.3
4xeyB-1opkA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.52A 4xeyB-1opkA:
36.3
4xeyB-1opkA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.47A 4xeyB-1opkA:
36.3
4xeyB-1opkA:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.72A 4xliA-1opkA:
36.5
4xliA-1opkA:
92.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.68A 4xliB-1opkA:
36.7
4xliB-1opkA:
92.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 8 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
0.59A 4zauA-1opkA:
31.9
4zauA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 9 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.56A 5aaaA-1opkA:
31.0
5aaaA-1opkA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.65A 5aabA-1opkA:
31.0
5aabA-1opkA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 337
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 5aacA-1opkA:
30.9
5aacA-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
ALA A 288
LYS A 290
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
1.04A 5ajqA-1opkA:
22.7
5ajqA-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
GLY A 268
ALA A 288
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.98A 5ajqA-1opkA:
22.7
5ajqA-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 10 ALA A 288
PHE A 336
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.68A 5ajqB-1opkA:
23.0
5ajqB-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 5bvwA-1opkA:
29.8
5bvwA-1opkA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 LEU A 267
VAL A 275
ALA A 288
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 5h2uA-1opkA:
29.5
5h2uA-1opkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.78A 5h2uB-1opkA:
29.5
5h2uB-1opkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 LEU A 267
ALA A 288
ILE A 332
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.75A 5h2uC-1opkA:
29.3
5h2uC-1opkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 GLY A 268
VAL A 275
ALA A 288
ILE A 332
THR A 334
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.69A 5hesA-1opkA:
10.6
5hesA-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLY A 268
ALA A 288
LYS A 290
ILE A 332
THR A 334
ASP A 344
P16  A   2 ( 4.3A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
1.00A 5hesB-1opkA:
27.3
5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLY A 268
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.67A 5hesB-1opkA:
27.3
5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLY A 269
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.76A 5hesB-1opkA:
27.3
5hesB-1opkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 ALA A 288
LYS A 290
GLU A 305
THR A 334
LEU A 373
HIS A 380
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
None
0.55A 5hi2A-1opkA:
26.4
5hi2A-1opkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.40A 5hieA-1opkA:
25.4
5hieA-1opkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.40A 5hieB-1opkA:
25.4
5hieB-1opkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 12 VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.40A 5hieD-1opkA:
25.5
5hieD-1opkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
LYS A 290
ILE A 332
THR A 334
GLY A 340
GLU A 348
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.74A 5i9xA-1opkA:
31.6
5i9xA-1opkA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
LYS A 290
MET A 309
THR A 334
GLY A 340
GLU A 348
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
0.83A 5i9yA-1opkA:
31.0
5i9yA-1opkA:
25.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 10 LEU A 267
TYR A 272
VAL A 275
GLU A 305
ILE A 332
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
0.74A 5mo4A-1opkA:
54.2
5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 10 LEU A 267
VAL A 275
LYS A 290
GLU A 305
ILE A 332
PHE A 336
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
0.58A 5mo4A-1opkA:
54.2
5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
VAL A 308
MET A 309
ILE A 312
LEU A 317
HIS A 380
LEU A 389
P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-4.4A)
0.62A 5mo4A-1opkA:
54.2
5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
VAL A 308
MET A 309
LEU A 317
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.59A 5mo4A-1opkA:
54.2
5mo4A-1opkA:
98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
VAL A 308
MET A 309
LEU A 317
VAL A 318
HIS A 380
LEU A 389
P16  A   2 (-3.4A)
None
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
None
P16  A   2 (-4.4A)
0.58A 5mo4A-1opkA:
54.2
5mo4A-1opkA:
98.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 GLY A 273
VAL A 275
ALA A 288
LYS A 290
ILE A 332
THR A 334
None
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
0.83A 5p9iA-1opkA:
30.0
5p9iA-1opkA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 ALA A 288
GLU A 305
MET A 309
VAL A 318
PHE A 336
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.43A 5te0A-1opkA:
23.3
5te0A-1opkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
1.07A 5vcvA-1opkA:
22.9
5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
THR A 334
P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
0.51A 5vcvA-1opkA:
22.9
5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
6 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
THR A 334
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
0.59A 5vcyA-1opkA:
22.8
5vcyA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.65A 5y7zA-1opkA:
22.7
5y7zA-1opkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.65A 5y7zA-1opkA:
22.7
5y7zA-1opkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.51A 5y80A-1opkA:
22.8
5y80A-1opkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
8 / 12 LEU A 267
GLY A 268
VAL A 275
ALA A 288
GLU A 305
MET A 309
GLY A 340
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
0.50A 5zv2A-1opkA:
31.5
5zv2A-1opkA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 LEU A 267
GLY A 268
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
GLY A 340
ALA A 399
P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
0.50A 5zv2B-1opkA:
31.3
5zv2B-1opkA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae)
5 / 12 SER P 249
VAL P 524
GLY P 224
ASN P 387
VAL P 254
None
None
None
ADP  P1612 (-3.6A)
None
1.10A 6bqgA-4crmP:
undetectable
6bqgA-4crmP:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
9 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.53A 6bsdA-1opkA:
29.6
6bsdA-1opkA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 4 GLN A 319
THR A 334
HIS A 380
LEU A 403
None
P16  A   2 (-3.7A)
None
None
1.28A 6f3nB-1opkA:
undetectable
6f3nB-1opkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
ILE A 332
THR A 334
MET A 337
GLY A 340
LEU A 389
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.72A 6fnmA-1opkA:
32.3
6fnmA-1opkA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
7 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
MET A 337
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
0.81A 6fnmA-1opkA:
32.3
6fnmA-1opkA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 GLN A 319
THR A 334
HIS A 380
LEU A 403
None
P16  A   2 (-3.7A)
None
None
1.29A 6gbnA-1opkA:
undetectable
6gbnA-1opkA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 GLN A 319
THR A 334
HIS A 380
LEU A 403
None
P16  A   2 (-3.7A)
None
None
1.28A 6gbnD-1opkA:
undetectable
6gbnD-1opkA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.70A 6hd4A-1opkA:
36.8
6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 TYR A 272
VAL A 308
MET A 337
GLY A 340
P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
0.76A 6hd4A-1opkA:
36.8
6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 VAL A 308
PHE A 336
MET A 337
GLY A 340
None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
0.47A 6hd4A-1opkA:
36.8
6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.64A 6hd4B-1opkA:
36.9
6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.5A)
0.70A 6hd4B-1opkA:
36.9
6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
TYR A 272
VAL A 308
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
0.84A 6hd4B-1opkA:
36.9
6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 6 LEU A 267
VAL A 308
PHE A 336
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
0.56A 6hd4B-1opkA:
36.9
6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
11 / 12 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.63A 6hd6A-1opkA:
36.7
6hd6A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
4 / 5 LEU A 267
ILE A 312
MET A 337
GLY A 340
P16  A   2 ( 4.2A)
None
None
P16  A   2 (-3.4A)
0.86A 6hd6A-1opkA:
36.7
6hd6A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
PHE A 336
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
0.68A 6hd6B-1opkA:
36.8
6hd6B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
10 / 12 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
PHE A 336
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
0.60A 6hd6B-1opkA:
36.8
6hd6B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 7 TYR A 272
VAL A 308
ILE A 332
MET A 337
GLY A 340
P16  A   2 (-3.6A)
None
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
0.75A 6hd6B-1opkA:
36.8
6hd6B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus
musculus)
5 / 7 VAL A 308
ILE A 332
MET A 337
GLY A 340
ALA A 399
None
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
0.58A 6hd6B-1opkA:
36.8
6hd6B-1opkA:
28.37