SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'P15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_J_BEZJ5041_0 (CES1 PROTEIN)	5ce5	TRIACYLGLYCEROL LIPASE (Geobacillus thermocatenulatu s)	4 / 4	GLY A 16 SER A 114 ILE A 320 HIS A 359	P15 A 403 ( 4.2A) P15 A 403 (-2.3A) 1PE A 404 (-4.6A) P15 A 403 (-4.2A)	1.17A	1yajJ-5ce5A: 7.9	1yajJ-5ce5A: 22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_B_ADNB401_1 (ADENOSINE KINASE, PUTATIVE)	5ce5	TRIACYLGLYCEROL LIPASE (Geobacillus thermocatenulatu s)	5 / 12	LEU A 171 ALA A 163 THR A 169 LEU A 300 GLY A 117	P15 A 403 ( 4.2A) None P15 A 403 ( 4.4A) None None	1.11A	3uq6B-5ce5A: undetectable	3uq6B-5ce5A: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_B_ADNB401_1 (PUTATIVE ADENOSINE KINASE)	5ce5	TRIACYLGLYCEROL LIPASE (Geobacillus thermocatenulatu s)	5 / 12	LEU A 171 ALA A 163 THR A 169 LEU A 300 GLY A 117	P15 A 403 ( 4.2A) None P15 A 403 ( 4.4A) None None	1.12A	3vaqB-5ce5A: undetectable	3vaqB-5ce5A: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X2T_I_PEMI202_1 (HEMOGLOBIN SUBUNIT ALPHA HEMOGLOBIN SUBUNIT BETA)	5ce5	TRIACYLGLYCEROL LIPASE (Geobacillus thermocatenulatu s)	4 / 8	ALA A 163 THR A 169 TRP A 31 ALA A 241	None P15 A 403 ( 4.4A) None None	0.96A	5x2tI-5ce5A: undetectable 5x2tJ-5ce5A: undetectable 5x2tK-5ce5A: undetectable 5x2tL-5ce5A: undetectable	5x2tI-5ce5A: 15.26 5x2tJ-5ce5A: 16.40 5x2tK-5ce5A: 15.26 5x2tL-5ce5A: 16.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YAJ_J_BEZJ5041_0","CES1 PROTEIN","5ce5","TRIACYLGLYCEROL LIPASE","Geobacillus thermocatenulatus",4,"GLY A  16;SER A 114;ILE A 320;HIS A 359","P15 A 403 ( 4.2A);P15 A 403 (-2.3A);1PE A 404 (-4.6A);P15 A 403 (-4.2A)","1.17A","1yajJ-5ce5A:7.9",null],["3UQ6_B_ADNB401_1","ADENOSINE KINASE, PUTATIVE","5ce5","TRIACYLGLYCEROL LIPASE","Geobacillus thermocatenulatus",5,"LEU A 171;ALA A 163;THR A 169;LEU A 300;GLY A 117","P15 A 403 ( 4.2A);None;P15 A 403 ( 4.4A);None;None","1.11A","3uq6B-5ce5A:undetectable","1yajJ-5ce5A:22.24"],["3VAQ_B_ADNB401_1","PUTATIVE ADENOSINE KINASE","5ce5","TRIACYLGLYCEROL LIPASE","Geobacillus thermocatenulatus",5,"LEU A 171;ALA A 163;THR A 169;LEU A 300;GLY A 117","P15 A 403 ( 4.2A);None;P15 A 403 ( 4.4A);None;None","1.12A","3vaqB-5ce5A:undetectable","3uq6B-5ce5A:19.41"],["5X2T_I_PEMI202_1","HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA;HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA","5ce5","TRIACYLGLYCEROL LIPASE","Geobacillus thermocatenulatus",4,"ALA A 163;THR A 169;TRP A  31;ALA A 241","None;P15 A 403 ( 4.4A);None;None","0.96A","5x2tI-5ce5A:undetectable;5x2tJ-5ce5A:undetectable;5x2tK-5ce5A:undetectable;5x2tL-5ce5A:undetectable","3vaqB-5ce5A:19.41"]]