SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OYP'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
None
None
OYP  A 664 (-3.3A)
None
None
1.10A 1kiaA-3rdeA:
undetectable
1kiaA-3rdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
None
None
OYP  A 664 (-3.3A)
None
None
1.10A 1kiaB-3rdeA:
undetectable
1kiaB-3rdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
None
None
OYP  A 664 (-3.3A)
None
None
1.11A 1kiaC-3rdeA:
undetectable
1kiaC-3rdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
None
None
OYP  A 664 (-3.3A)
None
None
1.10A 1nbhB-3rdeA:
undetectable
1nbhB-3rdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
None
None
OYP  A 664 (-3.3A)
None
None
1.16A 1nbiB-3rdeA:
undetectable
1nbiB-3rdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
3 / 3 LEU A 408
HIS A 366
ILE A 400
OYP  A 664 (-3.7A)
FE2  A   1 ( 3.4A)
OYP  A 664 ( 4.6A)
0.55A 1s9pB-3rdeA:
undetectable
1s9pB-3rdeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
4 / 6 ILE A 593
GLU A 357
HIS A 361
HIS A 545
OYP  A 664 (-4.3A)
OYP  A 664 (-3.6A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
0.87A 1y93A-3rdeA:
undetectable
1y93A-3rdeA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
3 / 3 THR A 237
LYS A 189
GLU A 357
None
None
OYP  A 664 (-3.6A)
1.01A 3ijdB-3rdeA:
undetectable
3ijdB-3rdeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
4 / 5 ILE A 593
GLU A 357
HIS A 361
HIS A 545
OYP  A 664 (-4.3A)
OYP  A 664 (-3.6A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
0.69A 3ljgA-3rdeA:
undetectable
3ljgA-3rdeA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
4 / 7 PHE A 175
ASN A 401
ALA A 404
LEU A 597
OYP  A 664 (-4.1A)
None
OYP  A 664 (-3.3A)
OYP  A 664 ( 4.9A)
0.90A 3t3sC-3rdeA:
undetectable
3t3sC-3rdeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
4 / 5 ILE A 593
GLU A 357
HIS A 361
HIS A 545
OYP  A 664 (-4.3A)
OYP  A 664 (-3.6A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
0.87A 5n5kA-3rdeA:
undetectable
5n5kA-3rdeA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus
scrofa)
4 / 6 LEU A 179
SER A 178
PHE A 175
ASP A 174
OYP  A 664 (-3.3A)
None
OYP  A 664 (-4.1A)
None
1.15A 5om3A-3rdeA:
undetectable
5om3B-3rdeA:
undetectable
5om3A-3rdeA:
11.23
5om3B-3rdeA:
5.52