SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OXY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 234
PHE A 378
LEU A 333
PHE A 228
ASP A 388
 FE2  A 502 ( 3.3A)
OXY  A 503 (-4.7A)
None
OXY  A 503 ( 4.1A)
FE2  A 502 ( 2.2A)
 1.42A 1a4lB-1wqlA:
undetectable		 1a4lB-1wqlA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.07A 1dz4A-3ubcA:
undetectable		 1dz4A-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.07A 1dz4B-3ubcA:
undetectable		 1dz4B-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 5 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.06A 1dz6A-3ubcA:
undetectable		 1dz6A-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 8 HIS A 103
HIS A 159
HIS A 157
HIS A 105
 OXY  A 403 ( 3.9A)
OXY  A 403 (-3.5A)
CU  A 402 ( 3.2A)
CU  A 402 (-3.2A)
 0.97A 1ei6D-5mkmA:
undetectable		 1ei6D-5mkmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.63A 1hrkA-3ubcA:
undetectable		 1hrkA-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.60A 1hrkB-3ubcA:
undetectable		 1hrkB-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 GLU A  81
HIS A  24
HIS A 146
ASP A 165
PRO A 224
 FEO  A 404 (-2.6A)
OXY  A 405 ( 4.8A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 2.3A)
None
 1.35A 1ituA-1e5dA:
undetectable		 1ituA-1e5dA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 GLU A  81
HIS A  24
HIS A 146
ASP A 165
PRO A 224
 FEO  A 404 (-2.6A)
OXY  A 405 ( 4.8A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 2.3A)
None
 1.37A 1ituB-1e5dA:
undetectable		 1ituB-1e5dA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.4A)
None
OXY  B 202 (-4.1A)
HEM  B 201 (-3.3A)
 0.82A 1lh6A-4yu4B:
13.7		 1lh6A-4yu4B:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.35A 1os2A-5jigA:
3.2		 1os2A-5jigA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		4 / 4 HIS A 494
GLU A 501
HIS A 182
HIS A 444
 CU  A 603 ( 3.1A)
OXY  A 605 ( 4.3A)
CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
 1.17A 1os2D-3zx1A:
undetectable		 1os2D-3zx1A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.30A 1os2D-5jigA:
2.1		 1os2D-5jigA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 10 THR A  62
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.68A 1r55A-5jigA:
4.0		 1r55A-5jigA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.07A 1t85A-3ubcA:
undetectable		 1t85A-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 5 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 1t88B-3ubcA:
undetectable		 1t88B-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		4 / 4 HIS A 494
GLU A 501
HIS A 182
HIS A 444
 CU  A 603 ( 3.1A)
OXY  A 605 ( 4.3A)
CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
 1.27A 1uttA-3zx1A:
undetectable		 1uttA-3zx1A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1uttA-5jigA:
3.6		 1uttA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1utzA-5jigA:
3.1		 1utzA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1utzB-5jigA:
2.3		 1utzB-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.10A 1uyuB-3ubcA:
undetectable		 1uyuB-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		3 / 3 THR A 137
GLU A 501
HIS A 141
 None
OXY  A 605 ( 4.3A)
CU  A 602 (-3.0A)
 0.57A 1xwfA-3zx1A:
undetectable		 1xwfA-3zx1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		3 / 3 THR A 137
GLU A 501
HIS A 141
 None
OXY  A 605 ( 4.3A)
CU  A 602 (-3.0A)
 0.56A 1xwfB-3zx1A:
undetectable		 1xwfB-3zx1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		3 / 3 THR A 137
GLU A 501
HIS A 141
 None
OXY  A 605 ( 4.3A)
CU  A 602 (-3.0A)
 0.57A 1xwfC-3zx1A:
undetectable		 1xwfC-3zx1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		3 / 3 THR A 137
GLU A 501
HIS A 141
 None
OXY  A 605 ( 4.3A)
CU  A 602 (-3.0A)
 0.56A 1xwfD-3zx1A:
undetectable		 1xwfD-3zx1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4qma CYSTEINE DIOXYGENASE
TYPE I
(Cupriavidus
pinatubonensis) 		3 / 3 PHE A  83
ARG A 130
ASN A 151
 OXY  A 302 (-4.5A)
None
None
 0.92A 1xzxX-4qmaA:
undetectable		 1xzxX-4qmaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.31A 1y93A-5jigA:
3.2		 1y93A-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.04A 1yrcA-3ubcA:
undetectable		 1yrcA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.04A 1yrdA-3ubcA:
undetectable		 1yrdA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 12 HIS A 454
ILE A 455
LEU A 388
VAL A 437
SER A 205
 OXY  A 511 ( 3.2A)
CU  A 501 (-3.8A)
None
None
None
 1.20A 1zq9A-3t6wA:
undetectable		 1zq9A-3t6wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.10A 2bteA-1e5dA:
2.5		 2bteA-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.18A 2bteD-1e5dA:
2.4		 2bteD-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 2feuA-3ubcA:
undetectable		 2feuA-3ubcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 452
HIS A 454
HIS A 110
HIS A 112
 CU  A 503 ( 3.3A)
OXY  A 511 ( 3.2A)
CU  A 502 ( 3.5A)
CU  A 503 (-3.4A)
 1.24A 2fqgA-3t6wA:
33.1		 2fqgA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.31A 2hu6A-5jigA:
3.4		 2hu6A-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.44A 2jihA-5jigA:
3.9		 2jihA-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 8 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.51A 2jihB-5jigA:
4.3		 2jihB-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 5 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.04A 2m56A-3ubcA:
undetectable		 2m56A-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.44A 2ow9A-5jigA:
3.4		 2ow9A-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.42A 2ow9B-5jigA:
4.2		 2ow9B-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.47A 2ozrC-5jigA:
3.1		 2ozrC-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.45A 2ozrD-5jigA:
3.2		 2ozrD-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		4 / 4 HIS A 494
GLU A 501
HIS A 182
HIS A 444
 CU  A 603 ( 3.1A)
OXY  A 605 ( 4.3A)
CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
 1.35A 2ozrE-3zx1A:
undetectable		 2ozrE-3zx1A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.47A 2ozrE-5jigA:
3.0		 2ozrE-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.62A 2po5A-3ubcA:
undetectable		 2po5A-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		5 / 8 MET A 130
LEU A  75
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.93A 2po5B-3ubcA:
undetectable		 2po5B-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		5 / 9 MET A 130
LEU A  75
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.98A 2po7A-3ubcA:
1.0		 2po7A-3ubcA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		5 / 9 MET A 130
LEU A  75
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 1.00A 2po7B-3ubcA:
1.0		 2po7B-3ubcA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.23A 2v0gA-1e5dA:
undetectable		 2v0gA-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.10A 2zawA-3ubcA:
undetectable		 2zawA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 2zaxA-3ubcA:
undetectable		 2zaxA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.07A 2zuhA-3ubcA:
undetectable		 2zuhA-3ubcA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.08A 2zuiA-3ubcA:
undetectable		 2zuiA-3ubcA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 2zwtA-3ubcA:
undetectable		 2zwtA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 2zwuA-3ubcA:
undetectable		 2zwuA-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 3fwgA-3ubcA:
undetectable		 3fwgA-3ubcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 3fwgB-3ubcA:
undetectable		 3fwgB-3ubcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.00A 3fwiA-3ubcA:
undetectable		 3fwiA-3ubcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 3hy7A-5jigA:
3.8		 3hy7A-5jigA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 3hy7B-5jigA:
4.1		 3hy7B-5jigA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.42A 3kecA-5jigA:
3.3		 3kecA-5jigA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 3likA-5jigA:
2.4		 3likA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		4 / 4 HIS A 494
GLU A 501
HIS A 182
HIS A 444
 CU  A 603 ( 3.1A)
OXY  A 605 ( 4.3A)
CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
 1.22A 3lilA-3zx1A:
undetectable		 3lilA-3zx1A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.36A 3lilA-5jigA:
3.3		 3lilA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.30A 3ljgA-5jigA:
3.3		 3ljgA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.32A 3lkaA-5jigA:
3.4		 3lkaA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 PHE A 412
ILE A 324
ALA A 319
ILE A 294
ALA A 233
 None
OXY  A   3 (-3.9A)
OXY  A   3 (-3.2A)
YE1  A 997 ( 4.4A)
YE1  A 997 (-3.9A)
 0.94A 3nxuA-2pg8A:
undetectable		 3nxuA-2pg8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2pg8 DPGC
(Streptomyces
toyocaensis) 		5 / 12 PHE A 412
ILE A 324
ALA A 319
ILE A 294
ALA A 233
 None
OXY  A   3 (-3.9A)
OXY  A   3 (-3.2A)
YE1  A 997 ( 4.4A)
YE1  A 997 (-3.9A)
 0.92A 3nxuB-2pg8A:
undetectable		 3nxuB-2pg8A:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QPK_A_CUA603_0
(LACCASE-1)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.23A 3qpkA-3t6wA:
42.7		 3qpkA-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QPK_B_CUB603_0
(LACCASE-1)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.21A 3qpkB-3t6wA:
42.7		 3qpkB-3t6wA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 ILE A 197
TYR A 243
GLY A 227
TYR A  35
ASN A 170
 OXY  A 405 ( 4.7A)
None
None
None
None
 1.45A 3rlbB-1e5dA:
0.0		 3rlbB-1e5dA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1
(Oligobrachia
mashikoi) 		5 / 12 PHE D  36
HIS D  96
ILE D 141
VAL D 118
ILE D  69
 OXY  D 201 (-4.5A)
HEM  D 200 (-3.3A)
HEM  D 200 (-4.5A)
None
None
 1.30A 3sp9A-2zs0D:
undetectable		 3sp9A-2zs0D:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1
(Oligobrachia
mashikoi) 		4 / 7 PHE D  40
ASP D  37
PHE D  36
GLY D  54
 None
None
OXY  D 201 (-4.5A)
None
 0.94A 3vnsA-2zs0D:
undetectable		 3vnsA-2zs0D:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.60A 3w1wA-3ubcA:
undetectable		 3w1wA-3ubcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 3wrhE-3ubcA:
undetectable		 3wrhE-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.06A 3wrjE-3ubcA:
undetectable		 3wrjE-3ubcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.53A 4a7bA-5jigA:
4.0		 4a7bA-5jigA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A  67
HIS A 110
HIS A 400
HIS A 454
 CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.27A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 110
HIS A  67
HIS A 452
HIS A 454
HIS A 400
 CU  A 502 ( 3.5A)
CU  A 502 (-3.3A)
CU  A 503 ( 3.3A)
OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
 1.24A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.64A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 452
HIS A 454
HIS A 110
HIS A 112
 CU  A 503 ( 3.3A)
OXY  A 511 ( 3.2A)
CU  A 502 ( 3.5A)
CU  A 503 (-3.4A)
 1.29A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 4ek1A-3ubcA:
undetectable		 4ek1A-3ubcA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 12 ALA A 112
LEU A 113
THR A 116
VAL A  68
LEU A  72
 None
None
None
OXY  A 161 (-4.2A)
HEM  A 160 (-4.5A)
 1.13A 4g1bA-1yhuA:
13.5		 4g1bA-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		5 / 12 PHE A  29
TYR A  30
GLN A  65
LEU A 114
ILE A 139
 None
OXY  A 501 (-4.3A)
HEM  A 500 ( 3.6A)
None
None
 1.07A 4g1bA-3pt7A:
15.1		 4g1bA-3pt7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.01A 4g3rA-3ubcA:
undetectable		 4g3rA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.09A 4g3rB-3ubcA:
undetectable		 4g3rB-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.03A 4kkyX-3ubcA:
undetectable		 4kkyX-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 5 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.05A 4l49A-3ubcA:
undetectable		 4l49A-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.02A 4l4cA-3ubcA:
undetectable		 4l4cA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.10A 4l4dA-3ubcA:
undetectable		 4l4dA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.09A 4l4eA-3ubcA:
undetectable		 4l4eA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 8 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.08A 4l4fA-3ubcA:
undetectable		 4l4fA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 5kqi CATALASE-PEROXIDASE
(Burkholderia
pseudomallei) 		4 / 7 THR A 323
ARG A 108
TRP A  95
LEU A 105
 HEM  A 801 (-3.4A)
OXY  A 804 (-4.1A)
None
HEM  A 801 (-4.1A)
 1.36A 4nsbA-5kqiA:
undetectable		 4nsbA-5kqiA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4qma CYSTEINE DIOXYGENASE
TYPE I
(Cupriavidus
pinatubonensis) 		4 / 5 TYR A 164
HIS A 162
ASP A 145
TYR A 176
 OXY  A 302 (-4.9A)
None
None
None
 1.34A 4qdjA-4qmaA:
undetectable		 4qdjA-4qmaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qma CYSTEINE DIOXYGENASE
TYPE I
(Cupriavidus
pinatubonensis) 		5 / 11 GLY A 169
GLY A 188
ILE A 186
GLY A 165
PHE A  83
 None
None
None
EDO  A 308 ( 3.8A)
OXY  A 302 (-4.5A)
 1.14A 4qoiA-4qmaA:
undetectable
4qoiB-4qmaA:
undetectable		 4qoiA-4qmaA:
19.65
4qoiB-4qmaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 12 THR A 288
GLY A 367
PRO A 242
ALA A 245
PHE A 365
 None
OXY  A 492 ( 4.7A)
None
None
None
 1.01A 4rvgA-3kv6A:
undetectable		 4rvgA-3kv6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 12 VAL A 294
HIS A 293
LEU A 172
VAL A 239
GLY A 367
 None
None
None
None
OXY  A 492 ( 4.7A)
 1.46A 5i8fA-3kv6A:
undetectable		 5i8fA-3kv6A:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA501_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.66A 5mejA-3t6wA:
68.1		 5mejA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA502_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		6 / 6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.11A 5mejA-3t6wA:
68.1		 5mejA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA501_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.64A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA502_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		6 / 6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.10A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA501_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.65A 5mhuA-3t6wA:
68.0		 5mhuA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA502_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		6 / 6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.11A 5mhuA-3t6wA:
68.0		 5mhuA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA501_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.65A 5mhvA-3t6wA:
68.1		 5mhvA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA502_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		6 / 6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.11A 5mhvA-3t6wA:
68.1		 5mhvA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.01A 5mhwA-5mkmA:
11.6		 5mhwA-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.11A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhwA-3tbbA:
11.6		 5mhwA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mhwA-4e9xA:
27.1		 5mhwA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mhxA-3t6wA:
68.0		 5mhxA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.01A 5mhxA-5mkmA:
11.6		 5mhxA-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.11A 5mhxA-3t6wA:
68.0		 5mhxA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.83A 5mhxA-3t6wA:
68.0		 5mhxA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.90A 5mhxA-3tbbA:
10.9		 5mhxA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mhxA-4e9xA:
27.1		 5mhxA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mhyA-3t6wA:
68.0		 5mhyA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.02A 5mhyA-5mkmA:
11.6		 5mhyA-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.11A 5mhyA-3t6wA:
68.0		 5mhyA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5mhyA-3t6wA:
68.0		 5mhyA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhyA-3tbbA:
11.6		 5mhyA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mhyA-4e9xA:
27.1		 5mhyA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mhzA-3t6wA:
68.1		 5mhzA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.02A 5mhzA-5mkmA:
11.5		 5mhzA-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.11A 5mhzA-3t6wA:
68.1		 5mhzA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5mhzA-3t6wA:
68.1		 5mhzA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhzA-3tbbA:
11.6		 5mhzA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mhzA-4e9xA:
27.1		 5mhzA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mi1A-3t6wA:
68.0		 5mi1A-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.02A 5mi1A-5mkmA:
11.6		 5mi1A-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.12A 5mi1A-3t6wA:
68.0		 5mi1A-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.83A 5mi1A-3t6wA:
68.0		 5mi1A-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mi1A-3tbbA:
11.6		 5mi1A-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mi1A-4e9xA:
27.1		 5mi1A-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mi2A-3t6wA:
68.0		 5mi2A-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.12A 5mi2A-3t6wA:
68.0		 5mi2A-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.83A 5mi2A-3t6wA:
68.0		 5mi2A-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mi2A-3tbbA:
10.8		 5mi2A-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mi2A-4e9xA:
27.0		 5mi2A-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5miaA-3t6wA:
68.1		 5miaA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.12A 5miaA-3t6wA:
68.1		 5miaA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5miaA-3t6wA:
68.1		 5miaA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5miaA-3tbbA:
11.6		 5miaA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5miaA-4e9xA:
27.1		 5miaA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.71A 5mibA-3t6wA:
67.9		 5mibA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.12A 5mibA-3t6wA:
67.9		 5mibA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.83A 5mibA-3t6wA:
67.9		 5mibA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mibA-3tbbA:
11.5		 5mibA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mibA-4e9xA:
27.1		 5mibA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.71A 5micA-3t6wA:
68.1		 5micA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.13A 5micA-3t6wA:
68.1		 5micA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5micA-3t6wA:
68.1		 5micA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5micA-3tbbA:
10.9		 5micA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.86A 5micA-4e9xA:
27.1		 5micA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5midA-3t6wA:
68.0		 5midA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5mkm TWO-DOMAIN LACCASE
(Streptomyces
griseoflavus) 		4 / 4 HIS A 105
HIS A 159
HIS A 103
HIS A 157
 CU  A 402 (-3.2A)
OXY  A 403 (-3.5A)
OXY  A 403 ( 3.9A)
CU  A 402 ( 3.2A)
 1.02A 5midA-5mkmA:
11.6		 5midA-5mkmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.13A 5midA-3t6wA:
68.0		 5midA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5midA-3t6wA:
68.0		 5midA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5midA-3tbbA:
11.6		 5midA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5midA-4e9xA:
27.1		 5midA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA601_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mieA-3t6wA:
68.1		 5mieA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.13A 5mieA-3t6wA:
68.1		 5mieA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5mieA-3t6wA:
68.1		 5mieA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mieA-3tbbA:
11.0		 5mieA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.86A 5mieA-4e9xA:
27.1		 5mieA-4e9xA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.13A 5migA-3t6wA:
68.2		 5migA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA602_0
(LACCASE 2)		 3t6w LACCASE
(Steccherinum
ochraceum) 		4 / 5 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.83A 5migA-3t6wA:
68.2		 5migA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.90A 5migA-3tbbA:
11.5		 5migA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 4e9x MULTICOPPER OXIDASE
(uncultured
bacterium) 		4 / 5 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5migA-4e9xA:
27.1		 5migA-4e9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.33A 5n5jA-5jigA:
3.3		 5n5jA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 5n5kA-5jigA:
2.4		 5n5kA-5jigA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 5kqi CATALASE-PEROXIDASE
(Burkholderia
pseudomallei) 		4 / 5 ARG A 108
HIS A 112
PRO A 241
SER A 324
 OXY  A 804 (-4.1A)
OXY  A 804 (-3.9A)
HEM  A 801 ( 4.3A)
HEM  A 801 (-2.6A)
 0.11A 5syiB-5kqiA:
72.8		 5syiB-5kqiA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5kqi CATALASE-PEROXIDASE
(Burkholderia
pseudomallei) 		5 / 6 ARG A 108
HIS A 112
LEU A 236
PRO A 241
SER A 324
 OXY  A 804 (-4.1A)
OXY  A 804 (-3.9A)
None
HEM  A 801 ( 4.3A)
HEM  A 801 (-2.6A)
 0.11A 5syjA-5kqiA:
72.2		 5syjA-5kqiA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5kqi CATALASE-PEROXIDASE
(Burkholderia
pseudomallei) 		5 / 6 ARG A 108
HIS A 112
LEU A 236
PRO A 241
SER A 324
 OXY  A 804 (-4.1A)
OXY  A 804 (-3.9A)
None
HEM  A 801 ( 4.3A)
HEM  A 801 (-2.6A)
 0.14A 5syjB-5kqiA:
71.7		 5syjB-5kqiA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3bcq BETA-CHAIN
HEMOGLOBIN
(Brycon
cephalus) 		4 / 6 HIS B  63
MET B  91
ASN B 102
LEU B  88
 OXY  B 148 ( 3.8A)
HEM  B 147 (-4.0A)
None
None
 1.42A 5xdhA-3bcqB:
1.7
5xdhC-3bcqB:
1.5		 5xdhA-3bcqB:
22.54
5xdhC-3bcqB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.30A 5yn6A-4gs1A:
undetectable		 5yn6A-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.29A 5yniA-4gs1A:
undetectable		 5yniA-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.28A 5ynmA-4gs1A:
undetectable		 5ynmA-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT
IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 10 PHE A 228
GLY A 276
ALA A 321
LEU A 333
PHE B  80
 OXY  A 503 ( 4.1A)
None
None
None
None
 1.39A 5zjiA-1wqlA:
undetectable
5zjiJ-1wqlA:
undetectable		 5zjiA-1wqlA:
9.80
5zjiJ-1wqlA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3a0g HEMOGLOBIN SUBUNIT
BETA
(Cavia
porcellus) 		4 / 7 SER B  70
HIS B  63
GLY B  64
LEU B  88
 HEM  B 401 ( 3.8A)
OXY  B 501 ( 4.1A)
None
HEM  B 401 ( 4.7A)
 1.12A 6btxA-3a0gB:
undetectable		 6btxA-3a0gB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3zx1 OXIDOREDUCTASE,
PUTATIVE
(Campylobacter
jejuni) 		4 / 8 ASP A 150
ARG A 491
GLU A 501
VAL A 191
 None
None
OXY  A 605 ( 4.3A)
None
 1.14A 6fbvD-3zx1A:
undetectable		 6fbvD-3zx1A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3t6w LACCASE
(Steccherinum
ochraceum) 		5 / 12 HIS A  65
LEU A 459
SER A  63
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
GOL  A 508 (-4.6A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 1.31A 6n91A-3t6wA:
undetectable		 6n91A-3t6wA:
8.87