SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OXQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens) 		3 / 3 TRP A 148
ARG A 106
THR A 147
 None
OXQ  A 402 (-4.4A)
None
 0.85A 1df7A-1t2fA:
undetectable		 1df7A-1t2fA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 GLY A 237
ARG A 109
ILE A 239
VAL A 240
 None
OXQ  A 708 (-4.0A)
None
None
 0.92A 1rxcC-3czmA:
undetectable		 1rxcC-3czmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 GLY A 237
ARG A 109
ILE A 239
VAL A 240
 None
OXQ  A 702 (-3.9A)
None
None
 0.92A 1rxcC-3om9A:
undetectable		 1rxcC-3om9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 10 ALA A 254
ILE A  95
GLY A 162
HIS A 195
ASP A 143
 None
None
None
OXQ  A 708 ( 3.7A)
None
 1.39A 2b17A-3czmA:
undetectable		 2b17A-3czmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		6 / 12 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ARG A 109
ASP A 168
 None
None
None
None
OXQ  A 708 (-4.0A)
None
 0.99A 3uboA-3czmA:
6.0		 3uboA-3czmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 ALA A 164
ASN A 140
PRO A 250
HIS A 195
 NAD  A 701 (-3.7A)
OXQ  A 702 ( 3.2A)
NAD  A 701 ( 4.4A)
NAD  A 701 ( 3.5A)
 1.45A 3vxiA-3om9A:
0.0		 3vxiA-3om9A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ASP A 111
ASN A 140
SER A 103
 None
OXQ  A 708 ( 3.4A)
None
 0.83A 4obwA-3czmA:
4.8		 4obwA-3czmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ASP A 111
ASN A 140
SER A 105
 None
OXQ  A 702 ( 3.2A)
None
 0.47A 4obwA-3om9A:
3.8		 4obwA-3om9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 PHE A 115
GLY A  99
ALA A  98
ASN A 140
PRO A 114
 None
NAD  A 401 (-4.4A)
NAD  A 401 (-3.4A)
OXQ  A 708 ( 3.4A)
None
 1.11A 4rtpA-3czmA:
4.2		 4rtpA-3czmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 PHE A 115
GLY A  99
ALA A  98
ASN A 140
PRO A 114
 None
NAD  A 701 (-4.2A)
NAD  A 701 (-3.4A)
OXQ  A 702 ( 3.2A)
None
 1.11A 4rtpA-3om9A:
undetectable		 4rtpA-3om9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.48A 5syiB-3czmA:
undetectable		 5syiB-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.48A 5syjA-3czmA:
undetectable		 5syjA-3czmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3czm L-LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ARG A 109
HIS A 195
PRO A 250
SER A 245
 OXQ  A 708 (-4.0A)
OXQ  A 708 ( 3.7A)
NAD  A 401 ( 4.5A)
OXQ  A 708 (-3.0A)
 1.49A 5syjB-3czmA:
undetectable		 5syjB-3czmA:
18.26