SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OXM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 ASP A  62
LEU A  29
ILE A  95
THR A 246
ILE A 250
 None
None
None
OXM  A 355 (-4.6A)
None
 1.37A 1i18A-1a5zA:
0.0
1i18B-1a5zA:
0.0		 1i18A-1a5zA:
16.24
1i18B-1a5zA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 THR A 246
ILE A 250
ASP A  62
LEU A  29
ILE A  95
 OXM  A 355 (-4.6A)
None
None
None
None
 1.38A 1i18A-1a5zA:
0.0
1i18B-1a5zA:
undetectable		 1i18A-1a5zA:
16.24
1i18B-1a5zA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 6 ARG A 176
GLY A 525
ASP A 661
TYR A 490
 OXM  A1001 (-3.7A)
None
None
None
 0.82A 1kf6M-1h17A:
undetectable
1kf6N-1h17A:
0.0		 1kf6M-1h17A:
22.42
1kf6N-1h17A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 181
LEU A 183
ALA A 184
MET A 243
SER A 194
 OXM  A 302 (-3.2A)
None
None
None
None
 0.87A 2aa5A-4ol9A:
undetectable		 2aa5A-4ol9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 181
LEU A 183
ALA A 184
MET A 243
SER A 194
 OXM  A 302 (-3.2A)
None
None
None
None
 0.90A 2aa5B-4ol9A:
undetectable		 2aa5B-4ol9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 TYR A 735
ARG A 176
HIS A 704
GLN A 703
 None
OXM  A1001 (-3.7A)
None
None
 1.32A 2vxaA-1h17A:
0.0
2vxaC-1h17A:
0.0
2vxaE-1h17A:
0.0		 2vxaA-1h17A:
7.57
2vxaC-1h17A:
7.57
2vxaE-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 ARG A 176
TYR A 735
HIS A 704
GLN A 703
 OXM  A1001 (-3.7A)
None
None
None
 1.36A 2vxaA-1h17A:
0.0
2vxaB-1h17A:
0.0
2vxaK-1h17A:
0.0		 2vxaA-1h17A:
7.57
2vxaB-1h17A:
7.57
2vxaK-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 ARG A 176
TYR A 735
HIS A 704
GLN A 703
 OXM  A1001 (-3.7A)
None
None
None
 1.35A 2vxaB-1h17A:
0.0
2vxaC-1h17A:
0.0
2vxaG-1h17A:
0.0		 2vxaB-1h17A:
7.57
2vxaC-1h17A:
7.57
2vxaG-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 TYR A 735
ARG A 176
HIS A 704
GLN A 703
 None
OXM  A1001 (-3.7A)
None
None
 1.36A 2vxaD-1h17A:
0.0
2vxaF-1h17A:
0.0
2vxaI-1h17A:
0.0		 2vxaD-1h17A:
7.57
2vxaF-1h17A:
7.57
2vxaI-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 ARG A 176
TYR A 735
HIS A 704
GLN A 703
 OXM  A1001 (-3.7A)
None
None
None
 1.36A 2vxaD-1h17A:
0.0
2vxaE-1h17A:
0.0
2vxaL-1h17A:
0.0		 2vxaD-1h17A:
7.57
2vxaE-1h17A:
7.57
2vxaL-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 HIS A 704
GLN A 703
ARG A 176
TYR A 735
 None
None
OXM  A1001 (-3.7A)
None
 1.36A 2vxaB-1h17A:
0.0
2vxaG-1h17A:
0.0
2vxaH-1h17A:
0.0		 2vxaB-1h17A:
7.57
2vxaG-1h17A:
7.57
2vxaH-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 ARG A 176
TYR A 735
HIS A 704
GLN A 703
 OXM  A1001 (-3.7A)
None
None
None
 1.34A 2vxaH-1h17A:
0.0
2vxaI-1h17A:
0.0
2vxaJ-1h17A:
0.0		 2vxaH-1h17A:
7.57
2vxaI-1h17A:
7.57
2vxaJ-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 HIS A 704
GLN A 703
TYR A 735
ARG A 176
 None
None
None
OXM  A1001 (-3.7A)
 1.35A 2vxaD-1h17A:
0.0
2vxaJ-1h17A:
0.0
2vxaL-1h17A:
0.0		 2vxaD-1h17A:
7.57
2vxaJ-1h17A:
7.57
2vxaL-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 HIS A 704
GLN A 703
ARG A 176
TYR A 735
 None
None
OXM  A1001 (-3.7A)
None
 1.34A 2vxaH-1h17A:
0.0
2vxaJ-1h17A:
0.0
2vxaK-1h17A:
0.0		 2vxaH-1h17A:
7.57
2vxaJ-1h17A:
7.57
2vxaK-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1h17 FORMATE
ACETYLTRANSFERASE 1
(Escherichia
coli) 		4 / 8 HIS A 704
GLN A 703
ARG A 176
TYR A 735
 None
None
OXM  A1001 (-3.7A)
None
 1.35A 2vxaA-1h17A:
0.0
2vxaK-1h17A:
0.0
2vxaL-1h17A:
0.0		 2vxaA-1h17A:
7.57
2vxaK-1h17A:
7.57
2vxaL-1h17A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 11 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.22A 3a51A-4plhA:
undetectable		 3a51A-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 12 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.23A 3a51D-4plhA:
undetectable		 3a51D-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 12 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.19A 3a51E-4plhA:
undetectable		 3a51E-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ldn L-LACTATE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 106
ARG A 169
ASP A 235
 OXM  A 351 (-4.2A)
OXM  A 351 (-3.5A)
None
 0.90A 3wipG-1ldnA:
0.0
3wipH-1ldnA:
0.0		 3wipG-1ldnA:
21.23
3wipH-1ldnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.87A 4eq4A-6d8wA:
undetectable		 4eq4A-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.89A 4eqlA-6d8wA:
undetectable		 4eqlA-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.91A 4eqlB-6d8wA:
undetectable		 4eqlB-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 181
LEU A 183
ALA A 184
MET A 243
ALA A 239
 OXM  A 302 (-3.2A)
None
None
None
None
 0.99A 4fn9A-4ol9A:
undetectable		 4fn9A-4ol9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.93A 4l39A-6d8wA:
undetectable		 4l39A-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.92A 4l39B-6d8wA:
undetectable		 4l39B-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 246
ASP A 250
GLN A  77
 OXM  A 302 ( 2.7A)
NAP  A 301 ( 4.8A)
NAP  A 301 (-3.1A)
 0.94A 4oltA-4ol9A:
undetectable
4oltB-4ol9A:
undetectable		 4oltA-4ol9A:
22.43
4oltB-4ol9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A  77
SER A 246
ASP A 250
 NAP  A 301 (-3.1A)
OXM  A 302 ( 2.7A)
NAP  A 301 ( 4.8A)
 0.95A 4qwpA-4ol9A:
undetectable
4qwpB-4ol9A:
undetectable		 4qwpA-4ol9A:
23.12
4qwpB-4ol9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 LEU A 122
TYR A 121
GLY A 163
ILE A 118
ASP A 114
 None
None
None
OXM  A 303 ( 4.7A)
OXM  A 303 (-4.6A)
 1.38A 5hjiA-6d9yA:
7.1		 5hjiA-6d9yA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 ALA A  60
GLU A 101
LYS A 104
LEU A 107
 None
None
OXM  A 503 (-3.6A)
None
 0.87A 6ci6A-6d8wA:
undetectable		 6ci6A-6d8wA:
18.52