SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OXE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		5 / 10 GLY A  21
LEU A 112
PHE A 118
THR A 199
HIS A 224
 OXE  A 243 (-3.8A)
None
None
None
OXE  A 243 (-4.1A)
 1.50A 1a8uA-3e0xA:
27.5		 1a8uA-3e0xA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		5 / 12 MET A 126
LEU A 134
MET A 165
LEU A 169
THR A 199
 None
None
OXE  A 243 ( 4.6A)
None
None
 1.19A 1p93C-3e0xA:
undetectable		 1p93C-3e0xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		4 / 7 TYR A  88
HIS A 224
LEU A 198
MET A 165
 OXE  A 243 (-4.2A)
OXE  A 243 (-4.1A)
None
OXE  A 243 ( 4.6A)
 1.10A 1tuvA-3e0xA:
undetectable		 1tuvA-3e0xA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		4 / 5 PHE A 155
LEU A 134
PHE A 225
SER A  89
 None
None
None
OXE  A 243 (-2.8A)
 1.29A 1wrlC-3e0xA:
undetectable		 1wrlC-3e0xA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		3 / 3 LEU A 227
TYR A  88
GLY A  92
 None
OXE  A 243 (-4.2A)
None
 0.50A 2ocuA-3e0xA:
undetectable		 2ocuA-3e0xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		5 / 12 LEU A 158
THR A 157
LEU A 150
LEU A 227
HIS A  20
 OXE  A 243 (-4.7A)
None
None
None
None
 1.07A 2ouzA-3e0xA:
undetectable		 2ouzA-3e0xA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		5 / 12 GLY A  21
GLY A  23
MET A 165
ILE A  94
SER A  89
 OXE  A 243 (-3.8A)
None
OXE  A 243 ( 4.6A)
None
OXE  A 243 (-2.8A)
 1.14A 4iv0B-3e0xA:
undetectable		 4iv0B-3e0xA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		4 / 6 LEU A 227
TYR A  88
ILE A 143
GLY A 222
 None
OXE  A 243 (-4.2A)
None
None
 0.94A 4l39A-3e0xA:
undetectable		 4l39A-3e0xA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		5 / 12 GLY A  21
GLY A  23
MET A 165
ILE A  94
SER A  89
 OXE  A 243 (-3.8A)
None
OXE  A 243 ( 4.6A)
None
OXE  A 243 (-2.8A)
 1.13A 4mwzA-3e0xA:
2.4		 4mwzA-3e0xA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3e0x LIPASE-ESTERASE
RELATED PROTEIN
(Clostridium
acetobutylicum) 		4 / 6 TYR A  88
HIS A 224
GLY A 114
GLU A 196
 OXE  A 243 (-4.2A)
OXE  A 243 (-4.1A)
None
None
 1.35A 4zbqA-3e0xA:
undetectable		 4zbqA-3e0xA:
18.40