SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OTP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1wub CONSERVED
HYPOTHETICAL PROTEIN
TT1927B
(Thermus
thermophilus) 		5 / 11 LEU A 101
ILE A  50
PHE A  82
ALA A  48
GLU A 166
 OTP  A1001 ( 4.2A)
None
OTP  A1001 (-4.1A)
OTP  A1001 (-3.6A)
None
 1.21A 2v0mD-1wubA:
undetectable		 2v0mD-1wubA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.91A 3aicA-5ixgB:
undetectable		 3aicA-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.90A 3aicB-5ixgB:
undetectable		 3aicB-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.90A 3aicE-5ixgB:
undetectable		 3aicE-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.91A 3aicF-5ixgB:
undetectable		 3aicF-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.90A 3aicG-5ixgB:
undetectable		 3aicG-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ixg YCEI
(Burkholderia
cenocepacia) 		3 / 3 LEU B 151
TRP B  31
TYR B 153
 PEG  B 202 (-4.6A)
OTP  B 201 ( 4.6A)
OTP  B 201 ( 4.0A)
 0.87A 3aicH-5ixgB:
undetectable		 3aicH-5ixgB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 6 VAL A  30
GLY A  59
ARG A  57
LEU A 149
 None
None
OTP  A1174 (-3.9A)
OTP  A1174 ( 4.3A)
 0.98A 3bjwE-2x32A:
undetectable		 3bjwE-2x32A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 6 PHE A  66
ASN A  48
PHE A  28
THR A  52
 None
None
OTP  A1174 ( 4.7A)
None
 1.04A 3t3sB-2x32A:
undetectable		 3t3sB-2x32A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 8 PHE A  66
PHE A  14
ASN A  48
PHE A  28
THR A  52
 None
OTP  A1174 ( 4.2A)
None
OTP  A1174 ( 4.7A)
None
 1.26A 3t3sF-2x32A:
undetectable		 3t3sF-2x32A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1wub CONSERVED
HYPOTHETICAL PROTEIN
TT1927B
(Thermus
thermophilus) 		4 / 8 ILE A  80
LEU A  28
ILE A 137
PHE A  14
 None
None
None
OTP  A1001 (-4.2A)
 0.89A 4hb6A-1wubA:
undetectable		 4hb6A-1wubA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 8 ILE A  45
LEU A  47
ILE A 135
GLY A 106
 None
None
OTP  A1174 (-4.8A)
None
 0.86A 4hb6A-2x32A:
undetectable		 4hb6A-2x32A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 11 LEU A  47
VAL A 164
LEU A  12
LEU A 104
ALA A  74
 None
OTP  A1174 ( 4.6A)
None
OTP  A1174 ( 4.5A)
OTP  A1174 ( 4.9A)
 1.15A 4p65B-2x32A:
undetectable
4p65D-2x32A:
undetectable
4p65G-2x32A:
undetectable
4p65H-2x32A:
undetectable		 4p65B-2x32A:
11.59
4p65D-2x32A:
11.59
4p65G-2x32A:
11.67
4p65H-2x32A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 12 LEU A  47
VAL A 164
LEU A  12
LEU A 104
ALA A  74
 None
OTP  A1174 ( 4.6A)
None
OTP  A1174 ( 4.5A)
OTP  A1174 ( 4.9A)
 1.05A 4p65F-2x32A:
undetectable
4p65H-2x32A:
undetectable
4p65K-2x32A:
undetectable
4p65L-2x32A:
undetectable		 4p65F-2x32A:
11.59
4p65H-2x32A:
11.59
4p65K-2x32A:
11.67
4p65L-2x32A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 12 ILE A  35
GLY A  34
TYR A   3
ARG A 124
PHE A 166
 None
None
None
None
OTP  A1174 (-4.4A)
 1.23A 5igwA-2x32A:
undetectable		 5igwA-2x32A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 5 TYR A 170
TYR A   3
GLY A  34
GLY A  33
 OTP  A1174 (-4.7A)
None
None
None
 1.13A 5x7pA-2x32A:
undetectable		 5x7pA-2x32A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ixg YCEI
(Burkholderia
cenocepacia) 		4 / 8 ILE B  59
PHE B  35
ARG B 146
LEU B 107
 None
OTP  B 201 (-3.7A)
OTP  B 201 ( 4.9A)
OTP  B 201 ( 4.8A)
 0.86A 5zcoA-5ixgB:
undetectable
5zcoJ-5ixgB:
undetectable		 5zcoA-5ixgB:
15.56
5zcoJ-5ixgB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2x32 CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 7 VAL A  30
GLY A 109
ARG A  62
ALA A  74
 None
None
None
OTP  A1174 ( 4.9A)
 0.88A 6hd6B-2x32A:
undetectable		 6hd6B-2x32A:
22.07