SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OSE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 12 ILE A  61
ALA A 122
ILE A 126
PRO A 127
LEU A  33
 OSE  A  39 ( 4.5A)
None
None
None
None
 1.10A 1drfA-1ylnA:
undetectable		 1drfA-1ylnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 7 SER A  40
SER A  97
ALA A  95
ILE A 105
 OSE  A  39 ( 4.2A)
None
None
None
 1.03A 1fxhA-1ylnA:
undetectable
1fxhB-1ylnA:
undetectable		 1fxhA-1ylnA:
23.66
1fxhB-1ylnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4hf7 PUTATIVE
ACYLHYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  63
THR A 115
VAL A  68
PHE A  93
 OSE  A  62 ( 4.3A)
OSE  A  62 ( 4.4A)
None
None
 1.04A 4iarA-4hf7A:
undetectable		 4iarA-4hf7A:
19.14