SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OSA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KVL_A_CLSA371_1 (BETA-LACTAMASE)	3n2e	SHIKIMATE KINASE (Helicobacter pylori)	5 / 10	GLY A 80 LEU A 135 TYR A 136 THR A 78 GLY A 79	OSA A1001 (-3.3A) OSA A1001 (-3.5A) OSA A1001 (-4.8A) None None	1.11A	1kvlA-3n2eA: undetectable	1kvlA-3n2eA: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VFT_A_SORA1419_0 (XYLITOL OXIDASE)	3n2e	SHIKIMATE KINASE (Helicobacter pylori)	5 / 12	HIS A 85 THR A 32 GLU A 60 ARG A 57 THR A 78	None None None OSA A1001 (-3.9A) None	1.27A	2vftA-3n2eA: 0.0	2vftA-3n2eA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW1_A_STIA233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3n2e	SHIKIMATE KINASE (Helicobacter pylori)	5 / 10	PHE A 48 GLY A 80 GLY A 79 THR A 78 ILE A 7	OSA A1001 (-4.1A) OSA A1001 (-3.3A) None None None	1.35A	3fw1A-3n2eA: undetectable	3fw1A-3n2eA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V5Z_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3n2e	SHIKIMATE KINASE (Helicobacter pylori)	5 / 12	PHE A 56 ILE A 36 GLY A 79 LEU A 88 MET A 84	None None None None OSA A1001 (-4.6A)	1.22A	5v5zA-3n2eA: undetectable	5v5zA-3n2eA: 16.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KVL_A_CLSA371_1","BETA-LACTAMASE","3n2e","SHIKIMATE KINASE","Helicobacter pylori",5,"GLY A  80;LEU A 135;TYR A 136;THR A  78;GLY A  79","OSA A1001 (-3.3A);OSA A1001 (-3.5A);OSA A1001 (-4.8A);None;None","1.11A","1kvlA-3n2eA:undetectable",null],["2VFT_A_SORA1419_0","XYLITOL OXIDASE","3n2e","SHIKIMATE KINASE","Helicobacter pylori",5,"HIS A  85;THR A  32;GLU A  60;ARG A  57;THR A  78","None;None;None;OSA A1001 (-3.9A);None","1.27A","2vftA-3n2eA:0.0","1kvlA-3n2eA:18.23"],["3FW1_A_STIA233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3n2e","SHIKIMATE KINASE","Helicobacter pylori",5,"PHE A  48;GLY A  80;GLY A  79;THR A  78;ILE A   7","OSA A1001 (-4.1A);OSA A1001 (-3.3A);None;None;None","1.35A","3fw1A-3n2eA:undetectable","2vftA-3n2eA:18.10"],["5V5Z_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","3n2e","SHIKIMATE KINASE","Helicobacter pylori",5,"PHE A  56;ILE A  36;GLY A  79;LEU A  88;MET A  84","None;None;None;None;OSA A1001 (-4.6A)","1.22A","5v5zA-3n2eA:undetectable","3fw1A-3n2eA:23.08"]]