SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ORN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 GLU A 577
SER A 913
VAL A 893
ALA A  52
 None
None
ORN  A4010 ( 4.7A)
None
 1.06A 1fo4B-1c30A:
1.8		 1fo4B-1c30A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 ALA A 472
GLY A 471
ALA A 515
ILE A 461
SER A 363
 FAD  A 601 (-3.4A)
None
ORN  A 602 ( 3.5A)
None
FAD  A 601 (-3.6A)
 1.15A 1ve3B-5yb7A:
undetectable		 1ve3B-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 7 PHE A  22
THR A 126
GLY A 100
ASP A 147
 ORN  A 300 ( 3.7A)
ORN  A 300 (-3.9A)
None
None
 0.94A 2a1mA-3vvdA:
undetectable		 2a1mA-3vvdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 THR A 337
CYH A 331
VAL A  51
THR A 329
LEU A 346
 ORN  A 603 (-3.0A)
FAD  A 601 (-4.6A)
FAD  A 601 (-4.4A)
None
None
 1.15A 2qo5A-5yb7A:
undetectable		 2qo5A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 PHE A  25
PHE A  22
GLY A  99
GLY A 100
 None
ORN  A 300 ( 3.7A)
None
None
 1.00A 2qr2A-3vvdA:
undetectable
2qr2B-3vvdA:
undetectable		 2qr2A-3vvdA:
24.73
2qr2B-3vvdA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A  99
GLY A 100
PHE A  25
PHE A  22
 None
None
None
ORN  A 300 ( 3.7A)
 1.06A 2qr2A-3vvdA:
undetectable
2qr2B-3vvdA:
undetectable		 2qr2A-3vvdA:
24.73
2qr2B-3vvdA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 10 TYR A1012
GLY A1046
ALA A1049
ASP A1041
GLN A 932
 None
None
None
ORN  A4010 (-4.6A)
None
 1.47A 2xtkB-1c30A:
undetectable		 2xtkB-1c30A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 127
GLU A  19
SER A  78
HIS A  79
TYR A  96
 ORN  A 300 (-3.4A)
ORN  A 300 (-3.2A)
None
None
None
 1.38A 4ejwA-3vvdA:
undetectable		 4ejwA-3vvdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 THR A1043
GLY A1047
ASN A1045
LEU A 960
SER A1018
 ORN  A4010 ( 4.9A)
None
None
None
None
 1.36A 4pooA-1c30A:
3.5		 4pooA-1c30A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 8 ASP A 238
PHE A 239
VAL A 228
ASP A 236
 ORN  A 602 (-3.1A)
None
None
None
 1.11A 4xqgA-5yb7A:
2.1		 4xqgA-5yb7A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 8 ASP A 238
PHE A 239
VAL A 228
ASP A 236
 ORN  A 602 (-3.1A)
None
None
None
 1.09A 4xqgB-5yb7A:
3.1		 4xqgB-5yb7A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 4zdzA-1c30A:
0.0		 4zdzA-1c30A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.85A 4ze3A-1c30A:
0.0		 4ze3A-1c30A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.89A 5eseA-1c30A:
0.0		 5eseA-1c30A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 5esfA-1c30A:
0.0		 5esfA-1c30A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.86A 5esjA-1c30A:
0.0		 5esjA-1c30A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.92A 5esmA-1c30A:
0.0		 5esmA-1c30A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  95
TYR A  96
PHE A  25
TYR A 128
 None
None
None
ORN  A 300 (-4.3A)
 1.30A 5v4vA-3vvdA:
undetectable		 5v4vA-3vvdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 SER A 237
ALA A 422
ALA A 472
SER A 363
 ORN  A 602 ( 4.4A)
None
FAD  A 601 (-3.4A)
FAD  A 601 (-3.6A)
 1.02A 6bocA-5yb7A:
undetectable
6bocB-5yb7A:
undetectable
6bocC-5yb7A:
undetectable
6bocD-5yb7A:
undetectable		 6bocA-5yb7A:
undetectable
6bocB-5yb7A:
undetectable
6bocC-5yb7A:
undetectable
6bocD-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		3 / 3 ARG A 359
PHE A 473
GLY A 475
 None
ORN  A 602 (-4.6A)
None
 0.69A 6fgdA-5yb7A:
3.9		 6fgdA-5yb7A:
undetectable