SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OP0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 146
TYR A 249
VAL A 239
GLY A 242
 OP0  A 401 (-3.0A)
OP0  A 401 (-3.6A)
None
None
 1.09A 1ekjC-4x68A:
undetectable
1ekjD-4x68A:
undetectable		 1ekjC-4x68A:
22.31
1ekjD-4x68A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 239
GLY A 242
GLN A 146
TYR A 249
 None
None
OP0  A 401 (-3.0A)
OP0  A 401 (-3.6A)
 1.16A 1ekjC-4x68A:
undetectable
1ekjD-4x68A:
undetectable		 1ekjC-4x68A:
22.31
1ekjD-4x68A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
LYS A 224
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.29A 1ghmA-5x5gA:
31.6		 1ghmA-5x5gA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
GLU A 156
THR A 206
LYS A 224
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.34A 1i2wA-5x5gA:
32.7		 1i2wA-5x5gA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
GLU A 156
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.97A 1i2wB-5x5gA:
32.9		 1i2wB-5x5gA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
GLU A 156
THR A 206
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.2A)
 0.35A 1i2wB-5x5gA:
32.9		 1i2wB-5x5gA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A  89
GLN A 146
ASN A 179
TYR A 249
THR A 343
GLY A 344
 OP0  A 401 ( 3.9A)
OP0  A 401 (-3.0A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.6A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 1.21A 1kvlA-4x68A:
56.1		 1kvlA-4x68A:
43.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		8 / 10 LEU A 145
GLN A 146
TYR A 177
ASN A 179
TYR A 249
LYS A 342
THR A 343
GLY A 344
 OP0  A 401 ( 4.8A)
OP0  A 401 (-3.0A)
OP0  A 401 (-4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.6A)
OP0  A 401 (-2.9A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 0.36A 1kvlA-4x68A:
56.1		 1kvlA-4x68A:
43.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
GLU A 156
THR A 206
LYS A 224
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.55A 1ymxA-5x5gA:
34.8		 1ymxA-5x5gA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
LYS A  59
SER A 120
LYS A 224
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.70A 1ymxA-5x5gA:
34.8		 1ymxA-5x5gA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
GLU A 156
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.60A 1ymxB-5x5gA:
34.8		 1ymxB-5x5gA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
LYS A  59
SER A 120
GLU A 156
LYS A 224
GLY A 226
SER A 227
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
OP0  A 305 (-3.6A)
 0.97A 1ymxB-5x5gA:
34.8		 1ymxB-5x5gA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
SER A 120
ASN A 122
THR A 206
LYS A 224
GLY A 226
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.32A 3hlwA-5x5gA:
34.8		 3hlwA-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A 120
ASN A 122
THR A 206
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.60A 3hlwA-5x5gA:
34.8		 3hlwA-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A 120
ASN A 122
THR A 206
LYS A 224
THR A 225
GLY A 226
SER A 227
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.57A 3hlwB-5x5gA:
34.9		 3hlwB-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LYS A  93
ASN A 179
LYS A 342
THR A 343
GLY A 344
 OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-2.9A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 0.39A 3huoA-4x68A:
15.8		 3huoA-4x68A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
ASN A 122
LYS A 224
THR A 225
GLY A 226
SER A 227
 OP0  A 305 (-3.6A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.69A 3huoA-5x5gA:
34.8		 3huoA-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
LYS A 224
THR A 225
GLY A 226
SER A 227
ASP A 229
 OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
OP0  A 305 (-3.6A)
 1.01A 3huoA-5x5gA:
34.8		 3huoA-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 12 LYS A  59
ASN A 122
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-3.6A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.72A 3huoB-5x5gA:
34.6		 3huoB-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 12 LYS A  59
LYS A 224
GLY A 226
SER A 227
ASP A 229
 OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
OP0  A 305 (-3.6A)
 1.01A 3huoB-5x5gA:
34.6		 3huoB-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 10 SER A 120
LEU A 211
ILE A 242
SER A  56
SER A 227
 OP0  A 305 (-2.7A)
None
None
OP0  A 305 (-1.5A)
OP0  A 305 (-2.4A)
 1.38A 3iluB-5x5gA:
undetectable
3iluE-5x5gA:
undetectable		 3iluB-5x5gA:
22.74
3iluE-5x5gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 11 ILE A 242
SER A  56
SER A 227
SER A 120
LEU A 211
 None
OP0  A 305 (-1.5A)
OP0  A 305 (-2.4A)
OP0  A 305 (-2.7A)
None
 1.40A 3iluB-5x5gA:
undetectable
3iluE-5x5gA:
undetectable		 3iluB-5x5gA:
22.74
3iluE-5x5gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  90
LYS A  93
ASN A 179
GLY A 344
THR A 346
ARG A 376
 OP0  A 401 (-1.3A)
OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.3A)
None
None
 0.95A 3mzeA-4x68A:
15.1		 3mzeA-4x68A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  90
LYS A  93
ASN A 179
THR A 343
GLY A 344
THR A 346
 OP0  A 401 (-1.3A)
OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
None
 0.69A 3mzeA-4x68A:
15.1		 3mzeA-4x68A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
LYS A  59
ASN A 122
THR A 225
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.78A 3mzeA-5x5gA:
14.6		 3mzeA-5x5gA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.63A 3ny4A-5x5gA:
32.0		 3ny4A-5x5gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
SER A 120
ASN A 122
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.64A 3q07A-5x5gA:
34.6		 3q07A-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
SER A 120
ASN A 122
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.59A 3q07B-5x5gA:
34.5		 3q07B-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.20A 3sh8A-5x5gA:
32.7		 3sh8A-5x5gA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
LYS A  59
SER A 120
ASN A 122
LYS A 224
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 1.00A 3sh8B-5x5gA:
32.4		 3sh8B-5x5gA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 LYS A  59
SER A 120
ASN A 122
THR A 206
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.47A 4euzA-5x5gA:
33.8		 4euzA-5x5gA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 10 SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.46A 4fh2A-5x5gA:
31.3		 4fh2A-5x5gA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		5 / 10 SER A 120
ASN A 122
THR A 225
GLY A 226
ARG A 210
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 1.32A 4fh2A-5x5gA:
31.3		 4fh2A-5x5gA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.21A 4n9kA-5x5gA:
33.0		 4n9kA-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 1.01A 4n9kB-5x5gA:
32.9		 4n9kB-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 367
GLY A 350
SER A 345
GLY A  53
ASN A  49
 None
None
OP0  A 401 (-4.6A)
None
None
 1.10A 4obwA-4x68A:
undetectable		 4obwA-4x68A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A 120
ASN A 122
THR A 206
LYS A 224
THR A 225
GLY A 226
SER A 227
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.73A 4pm5A-5x5gA:
34.5		 4pm5A-5x5gA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 LYS A  59
SER A 120
ASN A 122
THR A 206
LYS A 224
GLY A 226
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.63A 4pm7A-5x5gA:
34.5		 4pm7A-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A 120
ASN A 122
THR A 206
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.55A 4pm9A-5x5gA:
34.6		 4pm9A-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
ASN A 122
LYS A 224
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 1.05A 5ghyA-5x5gA:
32.9		 5ghyA-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
ASN A 122
LYS A 224
GLY A 226
ARG A 210
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 1.05A 5ghyB-5x5gA:
32.9		 5ghyB-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 11 SER A  56
SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.21A 5ghzA-5x5gA:
33.0		 5ghzA-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 10 SER A  56
SER A 120
ASN A 122
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.21A 5ghzB-5x5gA:
33.0		 5ghzB-5x5gA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.57A 6b5yB-5x5gA:
32.5		 6b5yB-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
LYS A 224
THR A 225
GLY A 226
ASP A 229
GLU A 270
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
SO4  A 302 (-3.0A)
 0.76A 6b5yD-5x5gA:
32.5		 6b5yD-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
SER A 120
THR A 206
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.49A 6b68B-5x5gA:
32.7		 6b68B-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
GLY A 226
ASP A 229
GLU A 270
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
SO4  A 302 (-3.0A)
 0.64A 6b68D-5x5gA:
32.6		 6b68D-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
SER A 120
THR A 206
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.48A 6b69A-5x5gA:
32.4
6b69B-5x5gA:
32.6		 6b69A-5x5gA:
15.56
6b69B-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
THR A 225
GLY A 226
GLU A 270
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
SO4  A 302 (-3.0A)
 0.41A 6b69D-5x5gA:
32.5		 6b69D-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.48A 6b6aB-5x5gA:
32.5		 6b6aB-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		8 / 12 SER A  56
SER A 120
ARG A 210
LYS A 224
THR A 225
GLY A 226
ASP A 229
GLU A 270
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
SO4  A 302 (-3.0A)
 0.60A 6b6aD-5x5gA:
32.4		 6b6aD-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
ARG A 210
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.37A 6b6cA-5x5gA:
32.6		 6b6cA-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
THR A 206
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.52A 6b6dA-5x5gA:
32.3		 6b6dA-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		7 / 12 SER A  56
SER A 120
THR A 206
ARG A 210
LYS A 224
THR A 225
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
 0.26A 6b6eA-5x5gA:
32.4		 6b6eA-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A  56
SER A 120
LYS A 224
THR A 225
GLY A 226
ASP A 229
 OP0  A 305 (-1.5A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.7A)
OP0  A 305 (-3.2A)
OP0  A 305 (-3.6A)
 0.70A 6b6fA-5x5gA:
32.3		 6b6fA-5x5gA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5x5g BETA-LACTAMASE
(Serratia
marcescens) 		6 / 12 SER A 120
ASN A 122
THR A 206
LYS A 224
GLY A 226
SER A 227
 OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
OP0  A 305 (-2.4A)
 0.52A 6c79A-5x5gA:
34.6		 6c79A-5x5gA:
14.64