SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ONM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 4 GLY A 399
ASP A 396
GLY A 439
THR A 415
 ONM  A 100 (-3.1A)
MN  A 582 (-2.7A)
ONM  A 100 (-3.6A)
None
 0.96A 1hxbB-1tl7A:
undetectable		 1hxbB-1tl7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.31A 5g6sA-5o5lA:
undetectable
5g6sG-5o5lA:
undetectable		 5g6sA-5o5lA:
23.08
5g6sG-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.27A 5g6sB-5o5lA:
undetectable
5g6sC-5o5lA:
undetectable		 5g6sB-5o5lA:
23.08
5g6sC-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 12 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.31A 5g6sB-5o5lA:
undetectable
5g6sC-5o5lA:
undetectable		 5g6sB-5o5lA:
23.08
5g6sC-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.30A 5g6sD-5o5lA:
undetectable
5g6sF-5o5lA:
undetectable		 5g6sD-5o5lA:
23.08
5g6sF-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 11 VAL A 341
LEU A 276
TYR A 280
PHE A 283
GLY A 299
 None
None
None
None
ONM  A 501 (-3.3A)
 1.31A 5g6sE-5o5lA:
undetectable
5g6sH-5o5lA:
undetectable		 5g6sE-5o5lA:
23.08
5g6sH-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.16A 5g6sD-5o5lA:
undetectable
5g6sF-5o5lA:
undetectable		 5g6sD-5o5lA:
23.08
5g6sF-5o5lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 5o5l ADENYLATE CYCLASE
(Mycobacterium
intracellulare) 		5 / 10 GLY A 299
VAL A 341
LEU A 276
TYR A 280
PHE A 283
 ONM  A 501 (-3.3A)
None
None
None
None
 1.26A 5g6sA-5o5lA:
undetectable
5g6sG-5o5lA:
undetectable		 5g6sA-5o5lA:
23.08
5g6sG-5o5lA:
23.08