SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ONL'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DGM_A_ADNA375_1 (ADENOSINE KINASE) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 9 | ILE A 376GLY A 374CYH A 398LEU A 394ASP A 343 | NoneNoneNoneONL A 601 ( 4.1A)None | 1.46A | 1dgmA-4zdkA:undetectable | 1dgmA-4zdkA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GHM_A_CEDA1_1 (BETA-LACTAMASE) |
4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homosapiens) | 6 / 12 | SER A 286LYS A 289ASN A 335LYS A 481SER A 482GLY A 483 | ONL A 601 (-1.4A)ONL A 601 ( 4.0A)ONL A 601 (-3.5A)ONL A 601 ( 4.8A)NoneONL A 601 (-3.5A) | 0.57A | 1ghmA-4o7dA:4.9 | 1ghmA-4o7dA:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1H4O_A_BEZA1162_0 (PEROXIREDOXIN 5) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 10 | PRO A 525PRO A 364GLY A 365PHE A 538THR A 521 | NoneNoneONL A 601 (-3.3A)NoneNone | 1.44A | 1h4oA-4zdkA:undetectable1h4oB-4zdkA:undetectable | 1h4oA-4zdkA:14.121h4oB-4zdkA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1H4O_D_BEZD1162_0 (PEROXIREDOXIN 5) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 9 | PRO A 364GLY A 365LEU A 537PHE A 538THR A 521 | NoneONL A 601 (-3.3A)NoneNoneNone | 1.44A | 1h4oD-4zdkA:undetectable | 1h4oD-4zdkA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HD2_A_BEZA201_0 (PEROXIREDOXIN 5RESIDUES 54-214) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 9 | PRO A 364GLY A 365LEU A 537PHE A 538THR A 521 | NoneONL A 601 (-3.3A)NoneNoneNone | 1.45A | 1hd2A-4zdkA:undetectable | 1hd2A-4zdkA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KNY_A_KANA558_1 (KANAMYCINNUCLEOTIDYLTRANSFERASE) |
3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) | 4 / 7 | ASP A 212GLU A 177GLU A 52GLU A 132 | NoneONL A 800 (-3.4A)NoneONL A 800 (-4.8A) | 1.06A | 1knyA-3dlaA:undetectable1knyB-3dlaA:undetectable | 1knyA-3dlaA:15.971knyB-3dlaA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KNY_B_KANB559_1 (KANAMYCINNUCLEOTIDYLTRANSFERASE) |
3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) | 4 / 8 | GLU A 132ASP A 212GLU A 177GLU A 52 | ONL A 800 (-4.8A)NoneONL A 800 (-3.4A)None | 1.15A | 1knyA-3dlaA:undetectable1knyB-3dlaA:undetectable | 1knyA-3dlaA:15.971knyB-3dlaA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1LII_A_ADNA699_2 (ADENOSINE KINASE) |
4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homosapiens) | 4 / 4 | SER A 482LEU A 505TYR A 466GLY A 487 | NoneNoneONL A 601 (-4.8A)None | 1.41A | 1liiA-4o7dA:undetectable | 1liiA-4o7dA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N4H_A_REAA500_1 (NUCLEAR RECEPTORROR-BETA) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 11 | ILE A 401ALA A 404VAL A 425VAL A 508LEU A 394 | NoneNoneNoneNoneONL A 601 ( 4.1A) | 1.07A | 1n4hA-4zdkA:undetectable | 1n4hA-4zdkA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1URM_A_BEZA201_0 (PEROXIREDOXIN 5) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 9 | PRO A 525PRO A 364GLY A 365PHE A 538THR A 521 | NoneNoneONL A 601 (-3.3A)NoneNone | 1.48A | 1urmA-4zdkA:undetectable | 1urmA-4zdkA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1X70_B_715B801_1 (DIPEPTIDYL PEPTIDASEIV) |
4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homosapiens) | 5 / 12 | GLU A 381SER A 384SER A 286VAL A 288TYR A 414 | ONL A 601 (-2.8A)NoneONL A 601 (-1.4A)NoneONL A 601 (-4.7A) | 1.28A | 1x70B-4o7dA:undetectable | 1x70B-4o7dA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZLQ_A_ACTA1507_0 (NICKEL-BINDINGPERIPLASMIC PROTEIN) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 3 / 3 | GLN A 397HIS A 476ARG A 477 | ONL A 601 (-3.0A)ONL A 601 (-4.9A)None | 0.70A | 1zlqA-4zdkA:undetectable | 1zlqA-4zdkA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 5 / 12 | ILE A1056LEU A1035GLY A1047SER A 208ARG A 206 | NoneNoneNoneNoneONL A2511 (-4.0A) | 1.25A | 2e7fA-1ofeA:7.5 | 2e7fA-1ofeA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E7F_B_C2FB4000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 5 / 12 | ILE A1056LEU A1035GLY A1047SER A 208ARG A 206 | NoneNoneNoneNoneONL A2511 (-4.0A) | 1.26A | 2e7fB-1ofeA:7.9 | 2e7fB-1ofeA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 5 / 12 | ILE A1056LEU A1035GLY A1047SER A 208ARG A 206 | NoneNoneNoneNoneONL A2511 (-4.0A) | 1.23A | 2ogyA-1ofeA:7.5 | 2ogyA-1ofeA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OGY_B_C2FB4000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 5 / 12 | ILE A1056LEU A1035GLY A1047SER A 208ARG A 206 | NoneNoneNoneNoneONL A2511 (-4.0A) | 1.24A | 2ogyB-1ofeA:7.9 | 2ogyB-1ofeA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W8Y_A_486A1000_2 (PROGESTERONERECEPTOR) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 4 / 7 | LEU A 331ASN A 227GLU A 229TYR A 203 | NoneONL A2511 (-3.9A)ONL A2511 (-3.4A)None | 1.26A | 2w8yA-1ofeA:0.0 | 2w8yA-1ofeA:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B9L_A_AZZA1010_1 (SERUM ALBUMIN) |
2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) | 4 / 8 | LEU A 23ILE A 3HIS A 71GLY A 99 | NoneNoneNoneONL A1609 (-3.5A) | 0.95A | 3b9lA-2j6hA:2.2 | 3b9lA-2j6hA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G4L_D_ROFD904_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homosapiens) | 3 / 3 | ASN A 335MET A 508PHE A 318 | ONL A 601 (-3.5A)NoneNone | 1.14A | 3g4lD-4o7dA:undetectable | 3g4lD-4o7dA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GY3_A_PNTA246_0 (CATIONIC TRYPSIN) |
1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) | 5 / 11 | LEU A 104GLN A 86GLY A 102CYH A 1GLY A 406 | NoneONL A 505 (-4.2A)ONL A 505 (-3.7A)ONL A 505 ( 1.8A)ONL A 505 ( 4.2A) | 1.12A | 3gy3A-1ecgA:undetectable | 3gy3A-1ecgA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GY3_A_PNTA246_0 (CATIONIC TRYPSIN) |
1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) | 5 / 11 | LEU A 104SER A 126GLY A 102CYH A 1GLY A 406 | NoneONL A 505 (-2.7A)ONL A 505 (-3.7A)ONL A 505 ( 1.8A)ONL A 505 ( 4.2A) | 1.15A | 3gy3A-1ecgA:undetectable | 3gy3A-1ecgA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U8Q_A_NPUA7231_1 (LACTOTRANSFERRIN) |
2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) | 4 / 5 | THR A 122GLY A 78PRO A 80ASN A 84 | ONL A1609 ( 4.7A)NoneNoneNone | 1.02A | 3u8qA-2j6hA:undetectable | 3u8qA-2j6hA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UFG_B_LEUB289_0 (GLYCYL-TRNASYNTHETASE ALPHASUBUNIT) |
3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) | 3 / 3 | PHE A 180SER A 203SER A 201 | ONL A 800 (-4.0A)ONL A 800 ( 4.6A)ONL A 800 ( 4.2A) | 0.95A | 3ufgB-3dlaA:undetectable | 3ufgB-3dlaA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ASD_A_BAXA1500_2 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 4 / 6 | ILE A 488LEU A 394ILE A 399CYH A 398 | NoneONL A 601 ( 4.1A)NoneNone | 0.79A | 4asdA-4zdkA:undetectable | 4asdA-4zdkA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 5 / 12 | ILE A1056LEU A1035GLY A1047SER A 208ARG A 206 | NoneNoneNoneNoneONL A2511 (-4.0A) | 1.23A | 4djfB-1ofeA:7.7 | 4djfB-1ofeA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L8F_B_MTXB301_1 (GAMMA-GLUTAMYLHYDROLASE) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 11 | GLY A 365GLY A 366LEU A 394HIS A 476HIS A 524 | ONL A 601 (-3.3A)ONL A 601 (-3.7A)ONL A 601 ( 4.1A)ONL A 601 (-4.9A)ONL A 601 ( 4.8A) | 0.38A | 4l8fB-4zdkA:19.0 | 4l8fB-4zdkA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L8F_D_MTXD301_1 (GAMMA-GLUTAMYLHYDROLASE) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 5 / 11 | GLY A 365GLY A 366LEU A 394HIS A 476HIS A 524 | ONL A 601 (-3.3A)ONL A 601 (-3.7A)ONL A 601 ( 4.1A)ONL A 601 (-4.9A)ONL A 601 ( 4.8A) | 0.42A | 4l8fD-4zdkA:18.9 | 4l8fD-4zdkA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0O_A_URFA303_1 (RRNA N-GLYCOSIDASE) |
1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) | 4 / 5 | TYR A 167ASN A 103TYR A 405ILE A 187 | NoneONL A 505 (-4.4A)NoneNone | 1.37A | 4o0oA-1ecgA:undetectable | 4o0oA-1ecgA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OBW_A_SAMA602_1 (2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL) |
1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) | 3 / 3 | ASP A 408ASN A 103SER A 81 | NoneONL A 505 (-4.4A)None | 0.46A | 4obwA-1ecgA:4.4 | 4obwA-1ecgA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_H_377H401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) |
3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) | 4 / 6 | ASN A 199GLU A 177GLU A 132TYR A 58 | NoneONL A 800 (-3.4A)ONL A 800 (-4.8A)GOL A 805 (-4.5A) | 1.23A | 4twdG-3dlaA:undetectable4twdH-3dlaA:undetectable | 4twdG-3dlaA:18.394twdH-3dlaA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UCK_B_SAMB2409_0 (RNA-DIRECTED RNAPOLYMERASE L) |
2j6h | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) | 5 / 12 | THR A 124GLY A 157SER A 176ALA A 353THR A 352 | ONL A1609 (-4.3A)NoneNoneNoneG6Q A1610 (-3.1A) | 1.16A | 4uckB-2j6hA:undetectable | 4uckB-2j6hA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EAJ_B_FOLB201_1 (DIHYDROFOLATEREDUCTASE) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 3 / 3 | ASP A 37ARG A 206ARG A 205 | NoneONL A2511 (-4.0A)None | 0.98A | 5eajB-1ofeA:0.0 | 5eajB-1ofeA:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GWY_E_010E6_0 (N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDEMAIN PROTEASE) |
4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) | 4 / 4 | THR A 521LEU A 392HIS A 524GLY A 395 | NoneNoneONL A 601 ( 4.8A)None | 1.13A | 5gwyA-4zdkA:undetectable | 5gwyA-4zdkA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OAJ_E_TKTE601_1 () |
3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) | 4 / 8 | GLU A 237CYH A 176TYR A 58ARG A 209 | NoneONL A 800 (-1.6A)GOL A 805 (-4.5A)ONL A 800 ( 4.8A) | 1.13A | 5oajD-3dlaA:0.05oajE-3dlaA:0.0 | 5oajD-3dlaA:17.385oajE-3dlaA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UAN_A_9CRA503_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) |
4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homosapiens) | 6 / 12 | ILE A 250ALA A 376GLN A 379ARG A 382VAL A 484CYH A 283 | NoneNoneNoneNoneONL A 601 (-3.7A)None | 1.25A | 5uanA-4o7dA:undetectable | 5uanA-4o7dA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6JI6_A_ACTA305_0 (GLUTATHIONES-TRANSFERASECLASS-MU 26 KDAISOZYME) |
1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp.PCC6803) | 4 / 5 | GLY A 225LEU A 332SER A 271GLN A 219 | NoneNoneONL A2511 (-3.2A)ONL A2511 (-4.3A) | 1.21A | 6ji6A-1ofeA:undetectable | 6ji6A-1ofeA:9.91 |