SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ON3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RU9_H_ACTH611_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	4z36	LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	4 / 6	LEU A 132 ASN A 214 LEU A 275 TRP A 210	ON3 A2000 ( 4.7A) None None ON3 A2000 (-4.2A)	1.14A	1ru9H-4z36A: undetectable 1ru9L-4z36A: undetectable	1ru9H-4z36A: 17.75 1ru9L-4z36A: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RUK_L_ACTL611_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	4z36	LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	4 / 6	LEU A 132 ASN A 214 LEU A 275 TRP A 210	ON3 A2000 ( 4.7A) None None ON3 A2000 (-4.2A)	1.09A	1rukH-4z36A: undetectable 1rukL-4z36A: undetectable	1rukH-4z36A: 17.75 1rukL-4z36A: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_C_DESC129_1 (TRANSTHYRETIN)	4z36	LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	4 / 6	LEU A 201 ALA A 199 SER A 203 SER A 205	None ON3 A2000 ( 4.5A) None None	1.00A	1tz8C-4z36A: undetectable 1tz8D-4z36A: undetectable	1tz8C-4z36A: 13.79 1tz8D-4z36A: 13.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RU9_H_ACTH611_0","IMMUNOGLOBULIN IGG2A, HEAVY CHAIN;IMMUNOGLOBULIN IGG2A, LIGHT CHAIN","4z36","LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562","Escherichia coli;Homo sapiens",4,"LEU A 132;ASN A 214;LEU A 275;TRP A 210","ON3 A2000 ( 4.7A);None;None;ON3 A2000 (-4.2A)","1.14A","1ru9H-4z36A:undetectable;1ru9L-4z36A:undetectable",null],["1RUK_L_ACTL611_0","IMMUNOGLOBULIN IGG2A, HEAVY CHAIN;IMMUNOGLOBULIN IGG2A, LIGHT CHAIN","4z36","LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562","Escherichia coli;Homo sapiens",4,"LEU A 132;ASN A 214;LEU A 275;TRP A 210","ON3 A2000 ( 4.7A);None;None;ON3 A2000 (-4.2A)","1.09A","1rukH-4z36A:undetectable;1rukL-4z36A:undetectable","1ru9H-4z36A:17.75;1ru9L-4z36A:18.16"],["1TZ8_C_DESC129_1","TRANSTHYRETIN;TRANSTHYRETIN","4z36","LYSOPHOSPHATIDIC ACID RECEPTOR 1,SOLUBLE CYTOCHROME B562","Escherichia coli;Homo sapiens",4,"LEU A 201;ALA A 199;SER A 203;SER A 205","None;ON3 A2000 ( 4.5A);None;None","1.00A","1tz8C-4z36A:undetectable;1tz8D-4z36A:undetectable","1rukH-4z36A:17.75;1rukL-4z36A:18.16"]]